O14786 · NRP1_HUMAN
- ProteinNeuropilin-1
- GeneNRP1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids923 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage (PubMed:19805273).
It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB (PubMed:10688880, PubMed:19805273, PubMed:9288753, PubMed:9529250).
Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity).
Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR (PubMed:30623799).
Isoform 2
May induce apoptosis by sequestering VEGF-165 (PubMed:10748121).
May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity
Features
Showing features for binding site.
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameNeuropilin-1
- Alternative names
- CD Antigen Name
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionO14786
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Isoform 2
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 22-856 | Extracellular | ||||
Sequence: FRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFVPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEALGMESGEIHSDQITASSQYSTNWSAERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKPVLFQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFEVYGCKITDYPCSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSYINEWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTFPALSTRFIRIYPERATHGGLGLRMELLGCEVEAPTAGPTTPNGNLVDECDDDQANCHSGTGDDFQLTGGTTVLATEKPTVIDSTIQSEFPTYGFNCEFGWGSHKTFCHWEHDNHVQLKWSVLTSKTGPIQDHTGDGNFIYSQADENQKGKVARLVSPVVYSQNSAHCMTFWYHMSGSHVGTLRVKLRYQKPEEYDQLVWMAIGHQGDHWKEGRVLLHKSLKLYQVIFEGEIGKGNLGGIAVDDISINNHISQEDCAKPADLDKKNPEIKIDETGSTPGYEGEGEGDKNISRKPGNVLKTLDP | ||||||
Transmembrane | 857-879 | Helical | ||||
Sequence: ILITIIAMSALGVLLGAVCGVVL | ||||||
Topological domain | 880-923 | Cytoplasmic | ||||
Sequence: YCACWHNGMSERNLSALENYNFELVDGVKLKKDKLNTQSTYSEA |
Keywords
- Cellular component
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_046536 | 179 | in dbSNP:rs7079053 | |||
Sequence: V → A | ||||||
Natural variant | VAR_046537 | 561 | in dbSNP:rs2228637 | |||
Sequence: F → L | ||||||
Natural variant | VAR_056957 | 733 | in dbSNP:rs2228638 | |||
Sequence: V → I |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1,101 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for signal, chain, disulfide bond, glycosylation, modified residue, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Signal | 1-21 | UniProt | |||||
Sequence: MERGLPLLCAVLALVLAPAGA | |||||||
Chain | PRO_0000021859 | 22-923 | UniProt | Neuropilin-1 | |||
Sequence: FRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFVPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEALGMESGEIHSDQITASSQYSTNWSAERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKPVLFQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFEVYGCKITDYPCSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSYINEWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTFPALSTRFIRIYPERATHGGLGLRMELLGCEVEAPTAGPTTPNGNLVDECDDDQANCHSGTGDDFQLTGGTTVLATEKPTVIDSTIQSEFPTYGFNCEFGWGSHKTFCHWEHDNHVQLKWSVLTSKTGPIQDHTGDGNFIYSQADENQKGKVARLVSPVVYSQNSAHCMTFWYHMSGSHVGTLRVKLRYQKPEEYDQLVWMAIGHQGDHWKEGRVLLHKSLKLYQVIFEGEIGKGNLGGIAVDDISINNHISQEDCAKPADLDKKNPEIKIDETGSTPGYEGEGEGDKNISRKPGNVLKTLDPILITIIAMSALGVLLGAVCGVVLYCACWHNGMSERNLSALENYNFELVDGVKLKKDKLNTQSTYSEA | |||||||
Disulfide bond | 27↔54 | UniProt | |||||
Sequence: CGDTIKIESPGYLTSPGYPHSYHPSEKC | |||||||
Disulfide bond | 82↔104 | UniProt | |||||
Sequence: CKYDYVEVFDGENENGHFRGKFC | |||||||
Disulfide bond | 147↔173 | UniProt | |||||
Sequence: CSQNYTTPSGVIKSPGFPEKYPNSLEC | |||||||
Glycosylation | 150 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Disulfide bond | 206↔228 | UniProt | |||||
Sequence: CRYDRLEIWDGFPDVGPHIGRYC | |||||||
Glycosylation | 261 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Disulfide bond | 275↔424 | UniProt | |||||
Sequence: CMEALGMESGEIHSDQITASSQYSTNWSAERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKPVLFQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFEVYGC | |||||||
Glycosylation | 300 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Disulfide bond | 431↔583 | UniProt | |||||
Sequence: CSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSYINEWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTFPALSTRFIRIYPERATHGGLGLRMELLGC | |||||||
Glycosylation | 522 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Glycosylation | 612 | UniProt | O-linked (Xyl...) (chondroitin sulfate) serine; alternate | ||||
Sequence: S | |||||||
Glycosylation | 612 | UniProt | O-linked (Xyl...) (heparan sulfate) serine; alternate | ||||
Sequence: S | |||||||
Glycosylation | 829 | UniProt | O-linked (Xyl...) (chondroitin sulfate) serine | ||||
Sequence: S | |||||||
Glycosylation | 842 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Modified residue | 894 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 894 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 899 | PRIDE | Phosphotyrosine | ||||
Sequence: Y | |||||||
Modified residue (large scale data) | 920 | PRIDE | Phosphotyrosine | ||||
Sequence: Y | |||||||
Modified residue (large scale data) | 921 | PRIDE | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Isoform 1
Expressed in fibroblasts (at protein level) (PubMed:36213313).
Expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain (PubMed:10688880, PubMed:9529250).
Expressed in the central nervous system, including olfactory related regions such as the olfactory tubercles and paraolfactory gyri (PubMed:33082293).
Isoform 2
Gene expression databases
Organism-specific databases
Interaction
Subunit
Interacts with FER (By similarity).
Interacts with PLXNB1 (PubMed:10520995).
Interacts with VEGFA (PubMed:19805273, PubMed:26503042).
Interacts with ABCB8/MITOSUR in mitochondria (PubMed:30623799).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | O14786 | FLNA P21333 | 2 | EBI-1187100, EBI-350432 | |
BINARY | O14786 | ITGA5 P08648 | 2 | EBI-1187100, EBI-1382311 | |
BINARY | O14786 | KDR P35968 | 2 | EBI-1187100, EBI-1005487 | |
XENO | O14786 | S P0DTC2 | 9 | EBI-1187100, EBI-25474821 | |
BINARY | O14786 | VEGFA P15692 | 4 | EBI-1187100, EBI-1026643 | |
BINARY | O14786-2 | VEGFA P15692-4 | 4 | EBI-6285281, EBI-1026691 |
Protein-protein interaction databases
Chemistry
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 27-141 | CUB 1 | ||||
Sequence: CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIF | ||||||
Domain | 147-265 | CUB 2 | ||||
Sequence: CSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFVPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVL | ||||||
Domain | 275-424 | F5/8 type C 1 | ||||
Sequence: CMEALGMESGEIHSDQITASSQYSTNWSAERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKPVLFQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFEVYGC | ||||||
Domain | 431-583 | F5/8 type C 2 | ||||
Sequence: CSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSYINEWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTFPALSTRFIRIYPERATHGGLGLRMELLGC | ||||||
Domain | 645-811 | MAM | ||||
Sequence: TYGFNCEFGWGSHKTFCHWEHDNHVQLKWSVLTSKTGPIQDHTGDGNFIYSQADENQKGKVARLVSPVVYSQNSAHCMTFWYHMSGSHVGTLRVKLRYQKPEEYDQLVWMAIGHQGDHWKEGRVLLHKSLKLYQVIFEGEIGKGNLGGIAVDDISINNHISQEDCAK | ||||||
Region | 820-845 | Disordered | ||||
Sequence: PEIKIDETGSTPGYEGEGEGDKNISR |
Domain
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
This entry describes 3 isoforms produced by Alternative splicing.
O14786-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- SynonymsMembrane-bound
- Length923
- Mass (Da)103,134
- Last updated2008-09-23 v3
- Checksum1EAC2FA6C8FD6A0B
O14786-2
- Name2
- SynonymsSoluble, SNRP1
O14786-3
- Name3
Computationally mapped potential isoform sequences
There are 10 potential isoforms mapped to this entry
Features
Showing features for sequence conflict, alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 26 | in Ref. 1; AAC51759 | ||||
Sequence: K → E | ||||||
Sequence conflict | 219 | in Ref. 5; CAD91133 | ||||
Sequence: D → G | ||||||
Alternative sequence | VSP_053498 | 587-621 | in isoform 3 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_004339 | 642-644 | in isoform 2 and isoform 3 | |||
Sequence: EFP → GIK | ||||||
Alternative sequence | VSP_004340 | 645-923 | in isoform 2 and isoform 3 | |||
Sequence: Missing | ||||||
Sequence conflict | 749 | in Ref. 2; AAC12921 | ||||
Sequence: D → H | ||||||
Sequence conflict | 855 | in Ref. 1; AAC51759 | ||||
Sequence: D → E |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF018956 EMBL· GenBank· DDBJ | AAC51759.1 EMBL· GenBank· DDBJ | mRNA | ||
AF016050 EMBL· GenBank· DDBJ | AAC12921.1 EMBL· GenBank· DDBJ | mRNA | ||
AF145712 EMBL· GenBank· DDBJ | AAF44344.1 EMBL· GenBank· DDBJ | mRNA | ||
BT006995 EMBL· GenBank· DDBJ | AAP35641.1 EMBL· GenBank· DDBJ | mRNA | ||
BX510902 EMBL· GenBank· DDBJ | CAD91133.1 EMBL· GenBank· DDBJ | mRNA | ||
EU332859 EMBL· GenBank· DDBJ | ABY87548.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AL353600 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL121748 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471072 EMBL· GenBank· DDBJ | EAW85942.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471072 EMBL· GenBank· DDBJ | EAW85944.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC007533 EMBL· GenBank· DDBJ | AAH07533.1 EMBL· GenBank· DDBJ | mRNA | ||
BC007737 EMBL· GenBank· DDBJ | AAH07737.1 EMBL· GenBank· DDBJ | mRNA |