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O14737 · PDCD5_HUMAN

  • Protein
    Programmed cell death protein 5
  • Gene
    PDCD5
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

May function in the process of apoptosis.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentcytosol
Cellular Componentextracellular exosome
Cellular Componentnucleus
Molecular Functionacetyltransferase activator activity
Molecular Functionbeta-tubulin binding
Molecular FunctionDNA binding
Molecular Functionheparin binding
Biological Processapoptotic process
Biological Processcellular response to transforming growth factor beta stimulus
Biological Processnegative regulation of chaperone-mediated protein folding
Biological Processpositive regulation of apoptotic process
Biological Processpositive regulation of gene expression
Biological Processregulation of apoptotic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Programmed cell death protein 5
  • Alternative names
    • TF-1 cell apoptosis-related protein 19 (Protein TFAR19)

Gene names

    • Name
      PDCD5
    • Synonyms
      TFAR19

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    O14737
  • Secondary accessions
    • B4DE64
    • Q53YC9
    • Q6IB70

Proteomes

Organism-specific databases

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 147 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for initiator methionine, modified residue, chain, modified residue (large scale data).

Type
IDPosition(s)Source
Description
Initiator methionine1UniProtRemoved
Modified residue2UniProtN-acetylalanine
ChainPRO_00001215452-125UniProtProgrammed cell death protein 5
Modified residue (large scale data)42PRIDEPhosphoserine
Modified residue51UniProtPhosphoserine
Modified residue (large scale data)51PRIDEPhosphoserine
Modified residue (large scale data)57PRIDEPhosphoserine
Modified residue63UniProtN6-acetyllysine
Modified residue119UniProtPhosphoserine
Modified residue (large scale data)119PRIDEPhosphoserine
Modified residue (large scale data)125PRIDEPhosphotyrosine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Widely expressed. Highest levels in heart, testis, kidney, pituitary gland, adrenal gland and placenta.

Induction

Activated in cells undergoing apoptosis.

Developmental stage

Expression in fetal tissues is significantly lower than in adult tissues.

Gene expression databases

Organism-specific databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntAct
BINARY O14737PICK1 Q9NRD53EBI-712290, EBI-79165
BINARY O14737RAD18 Q9NS913EBI-712290, EBI-2339393
BINARY O14737TRIM35 Q9UPQ4-23EBI-712290, EBI-17716262

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region16-36Disordered

Sequence similarities

Belongs to the PDCD5 family.

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

O14737-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    125
  • Mass (Da)
    14,285
  • Last updated
    2007-01-23 v3
  • MD5 Checksum
    60FC499941BC8E0335DBAB41D3BC4E54
MADEELEALRRQRLAELQAKHGDPGDAAQQEAKHREAEMRNSILAQVLDQSARARLSNLALVKPEKTKAVENYLIQMARYGQLSEKVSEQGLIEILKKVSQQTEKTTTVKFNRRKVMDSDEDDDY

O14737-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 89-125: EQGLIEILKKVSQQTEKTTTVKFNRRKVMDSDEDDDY → LDSLEELYCYLLYQNMASKGQLHLHWITEFLLTLRRNCWRE

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q3HM38Q3HM38_HUMANPDCD540
K7EQA1K7EQA1_HUMANPDCD587
K7ESJ4K7ESJ4_HUMANPDCD565
X6R2P6X6R2P6_HUMANPDCD555

Features

Showing features for alternative sequence, sequence conflict.

Type
IDPosition(s)Description
Alternative sequenceVSP_05620389-125in isoform 2
Sequence conflict104in Ref. 4; CAG33215

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF014955
EMBL· GenBank· DDBJ
AAD11579.1
EMBL· GenBank· DDBJ
mRNA
BT006694
EMBL· GenBank· DDBJ
AAP35340.1
EMBL· GenBank· DDBJ
mRNA
AK293486
EMBL· GenBank· DDBJ
BAG56975.1
EMBL· GenBank· DDBJ
mRNA
CR456934
EMBL· GenBank· DDBJ
CAG33215.1
EMBL· GenBank· DDBJ
mRNA
AC008474
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC015519
EMBL· GenBank· DDBJ
AAH15519.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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