A novel 160-kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family.Lavan B.E., Fantin V.R., Chang E.T., Lane W.S., Keller S.R., Lienhard G.E.View abstractCited forNUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 100-117; 233-240; 613-618; 836-843 AND 844-852, PHOSPHORYLATIONTissueKidneyCategoriesPTM / Processing, SequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 272:21403-21407 (1997)Cited in1
The DNA sequence of the human X chromosome.Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C.[...], Bentley D.R.View abstractCited forNUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNature 434:325-337 (2005)Cited in99+99+
No title available.Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H.[...], Venter J.C.Cited forNUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)Submission Submitted to EMBL/GenBank/DDBJ databases (SEP-2005)Cited in99+
Characterization of insulin receptor substrate 4 in human embryonic kidney 293 cells.Fantin V.R., Sparling J.D., Slot J.W., Keller S.R., Lienhard G.E., Lavan B.E.View abstractCited forFUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH GRB2 AND PIK3R1, PHOSPHORYLATIONCategoriesFunction, PTM / Processing, Interaction, Subcellular LocationSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 273:10726-10732 (1998)Cited in3Mapped to5
Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth factor-I receptor-mediated signal transduction.Koval A.P., Karas M., Zick Y., LeRoith D.View abstractCited forINTERACTION WITH CRK AND CRKLCategoriesInteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 273:14780-14787 (1998)Cited in3
Insulin receptor substrate-4 enhances insulin-like growth factor-I-induced cell proliferation.Qu B.-H., Karas M., Koval A., LeRoith D.View abstractCited forFUNCTIONCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 274:31179-31184 (1999)Cited in1Mapped to4
IRS-4 mediates protein kinase B signaling during insulin stimulation without promoting antiapoptosis.Uchida T., Myers M.G. Jr., White M.F.View abstractCited forFUNCTION, INTERACTION WITH GRB2 AND PIK3R1CategoriesFunction, InteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCMol. Cell. Biol. 20:126-138 (2000)Cited in1
The insulin-like growth factor I receptor-induced interaction of insulin receptor substrate-4 and Crk-II.Karas M., Koval A.P., Zick Y., LeRoith D.View abstractCited forINTERACTION WITH CRK, MUTAGENESIS OF TYR-700; TYR-717; TYR-743 AND TYR-779CategoriesDisease & Variants, InteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCEndocrinology 142:1835-1840 (2001)Cited in1Mapped to6
Insulin receptor substrate 4 associates with the protein IRAS.Sano H., Liu S.C.H., Lane W.S., Piletz J.E., Lienhard G.E.View abstractCited forINTERACTION WITH NISCHCategoriesInteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 277:19439-19447 (2002)Cited in7Mapped to4
Insulin receptor substrate-4 is expressed in muscle tissue without acting as a substrate for the insulin receptor.Schreyer S., Ledwig D., Rakatzi I., Kloeting I., Eckel J.View abstractCited forFUNCTION, TISSUE SPECIFICITYCategoriesFunction, ExpressionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCEndocrinology 144:1211-1218 (2003)Cited in1Mapped to5
Tyrosine phosphoproteomics of fibroblast growth factor signaling: a role for insulin receptor substrate-4.Hinsby A.M., Olsen J.V., Mann M.View abstractCited forPHOSPHORYLATION AT TYR-921, INTERACTION WITH SHC1; GRB2; PHOSPHOLIPASE C-GAMMA AND PHOSPHATIDYLINOSITOL 3-KINASE, IDENTIFICATION BY MASS SPECTROMETRYCategoriesPTM / Processing, Sequences, InteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 279:46438-46447 (2004)Cited in2Mapped to6
Protein phosphatase 4 interacts with and down-regulates insulin receptor substrate 4 following tumor necrosis factor-alpha stimulation.Mihindukulasuriya K.A., Zhou G., Qin J., Tan T.-H.View abstractCited forINTERACTION WITH PPP4C, INDUCTION, IDENTIFICATION BY MASS SPECTROMETRYCategoriesSequences, Expression, InteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 279:46588-46594 (2004)Cited in2Mapped to14
Interaction between Brk kinase and insulin receptor substrate-4.Qiu H., Zappacosta F., Su W., Annan R.S., Miller W.T.View abstractCited forINTERACTION WITH PTK6, IDENTIFICATION BY MASS SPECTROMETRYCategoriesSequences, InteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCOncogene 24:5656-5664 (2005)Cited in2Mapped to1
Role of insulin receptor substrate-4 in IGF-I-stimulated HEPG2 proliferation.Cuevas E.P., Escribano O., Chiloeches A., Ramirez Rubio S., Roman I.D., Fernandez-Moreno M.D., Guijarro L.G.View abstractCited forFUNCTION, TISSUE SPECIFICITYCategoriesFunction, ExpressionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Hepatol. 46:1089-1098 (2007)Cited in1Mapped to5
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.View abstractCited forIDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCAnal. Chem. 81:4493-4501 (2009)Cited in99+99+Mapped to18
The consensus coding sequences of human breast and colorectal cancers.Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J.[...], Velculescu V.E.View abstractCited forVARIANTS [LARGE SCALE ANALYSIS] VAL-20; GLU-215 AND ARG-557CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCScience 314:268-274 (2006)Cited in99+Mapped to3
Mutations in IRS4 are associated with central hypothyroidism.Heinen C.A., de Vries E.M., Alders M., Bikker H., Zwaveling-Soonawala N., van den Akker E.L.T., Bakker B., Hoorweg-Nijman G., Roelfsema F.[...], Fliers E.View abstractCited forINVOLVEMENT IN CHNG9, VARIANT CHNG9 215-GLY--ARG-1257 DELCategoriesSequences, Disease & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Med. Genet. 55:693-700 (2018)Cited in1
Insulin receptor substrate 2 and Shc play different roles in insulin-like growth factor I signaling.Kim B., Cheng H.L., Margolis B., Feldman E.L.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-2424297, Reactome: R-HSA-2424302PubMedEurope PMCJ Biol Chem 273:34543-34550 (1998)Mapped to9
Differential regulation of insulin receptor substrate-2 and mitogen- activated protein kinase tyrosine phosphorylation by phosphatidylinositol 3-kinase inhibitors in SH-SY5Y human neuroblastoma cells.Kim B., Leventhal P.S., White M.F., Feldman E.L.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-2424297, Reactome: R-HSA-2424302PubMedEurope PMCEndocrinology 139:4881-4889 (1998)Mapped to8
Common amino acid substitutions in insulin receptor substrate-4 are not associated with Type II diabetes mellitus or insulin resistance.Almind K., Frederiksen S.K., Ahlgren M.G., Urhammer S., Hansen T., Clausen J.O., Pedersen O.View abstractAnnotationNot Associated with OTHER: Type II diabetes mellitus or insulin resistance.CategoriesDisease & VariantsSourceGAD:128967PubMedEurope PMCDiabetologia 41:969-974 (1998)Mapped to1
Roles of insulin receptor substrate-1 and Shc on insulin-like growth factor I receptor signaling in early passages of cultured human fibroblasts.Takahashi Y., Tobe K., Kadowaki H., Katsumata D., Fukushima Y., Yazaki Y., Akanuma Y., Kadowaki T.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-2424297, Reactome: R-HSA-2424302PubMedEurope PMCEndocrinology 138:741-750 (1997)Mapped to8
Substrate specificities of the insulin and insulin-like growth factor 1 receptor tyrosine kinase catalytic domains.Xu B., Bird V.G., Miller W.T.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-2424297, Reactome: R-HSA-2424302PubMedEurope PMCJ Biol Chem 270:29825-29830 (1995)Mapped to8
Recombinant human insulin receptor substrate-1 protein. Tyrosine phosphorylation and in vitro binding of insulin receptor kinase.Siemeister G., al-Hasani H., Klein H.W., Kellner S., Streicher R., Krone W., Muller-Wieland D.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-2424297, Reactome: R-HSA-2424302PubMedEurope PMCJ Biol Chem 270:4870-4874 (1995)Mapped to6
Distinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domains.He W., O'Neill T.J., Gustafson T.A.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-2424297PubMedEurope PMCJ. Biol. Chem. 270:23258-23262 (1995)Cited in3Mapped to4
Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin- like growth factor I receptor.Craparo A., O'Neill T.J., Gustafson T.A.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-2424297PubMedEurope PMCJ. Biol. Chem. 270:15639-15643 (1995)Cited in4Mapped to4