O13979 · MU105_SCHPO
- ProteinUbiquitin carboxyl-terminal hydrolase mug105
- Genemug105
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids244 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Deubiquitinase with endodeubiquitinase activity that preferentially cleaves 'Lys-48'-linked polyubiquitin chains (PubMed:29476094, PubMed:29576528).
Shows only weak activity against 'Lys-63' and 'Lys-11'-linked chains (PubMed:29476094).
Has a role in meiosis (PubMed:16303567).
Shows only weak activity against 'Lys-63' and 'Lys-11'-linked chains (PubMed:29476094).
Has a role in meiosis (PubMed:16303567).
Catalytic activity
Kinetics
KM | SUBSTRATE | pH | TEMPERATURE[C] | NOTES | EVIDENCE | |
---|---|---|---|---|---|---|
12.2 μM | Arg-Leu-Arg-Gly-Gly-AMC |
kcat is 7.2 sec-1 with Arg-Leu-Arg-Gly-Gly-AMC as substrate.
Features
Showing features for active site, site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 42 | Nucleophile | |||
Site | 161 | Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole | |||
Active site | 165 | Proton acceptor | |||
Active site | 183 | ||||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | cysteine-type deubiquitinase activity | |
Molecular Function | K48-linked deubiquitinase activity | |
Molecular Function | ubiquitin-like protein peptidase activity | |
Biological Process | meiotic cell cycle |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameUbiquitin carboxyl-terminal hydrolase mug105
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Taphrinomycotina > Schizosaccharomycetes > Schizosaccharomycetales > Schizosaccharomycetaceae > Schizosaccharomyces
Accessions
- Primary accessionO13979
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Mutagenesis | 42 | Abolishes catalytic activity. | |||
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1 variant from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000278504 | 1-244 | Ubiquitin carboxyl-terminal hydrolase mug105 | ||
Proteomic databases
Structure
Family & Domains
Sequence similarities
Belongs to the peptidase C78 family. ZUFSP subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length244
- Mass (Da)28,084
- Last updated1998-01-01 v1
- ChecksumDE1A62DBE55BC1C7
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CU329670 EMBL· GenBank· DDBJ | CAB11605.1 EMBL· GenBank· DDBJ | Genomic DNA |