O13934 · ATG15_SCHPO
- ProteinPutative lipase atg15
- Geneatg15
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids424 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by atg15 is critical to life span extension (By similarity).
Catalytic activity
- a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H+
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 283 | Charge relay system | ||||
Sequence: S |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | fungal-type vacuole lumen | |
Cellular Component | membrane | |
Cellular Component | multivesicular body membrane | |
Cellular Component | vacuolar lumen | |
Molecular Function | lysophospholipase activity | |
Molecular Function | phospholipase activity | |
Molecular Function | triglyceride lipase activity | |
Biological Process | macroautophagy | |
Biological Process | multivesicular body membrane disassembly | |
Biological Process | neutral lipid catabolic process | |
Biological Process | phosphatidylserine catabolic process | |
Biological Process | piecemeal microautophagy of the nucleus |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended namePutative lipase atg15
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Taphrinomycotina > Schizosaccharomycetes > Schizosaccharomycetales > Schizosaccharomycetaceae > Schizosaccharomyces
Accessions
- Primary accessionO13934
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endosome, multivesicular body membrane ; Single-pass type II membrane protein
Prevacuolar compartment membrane ; Single-pass type II membrane protein
Note: From ER, targeted to vacuolar lumen at the MVB vesicles via the Golgi and the prevacuolar compartment (PVC).
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-9 | Cytoplasmic | ||||
Sequence: MSQLLFLRR | ||||||
Transmembrane | 10-30 | Helical; Signal-anchor for type II membrane protein | ||||
Sequence: FFFLFCFIIRISCTGVFESVI | ||||||
Topological domain | 31-424 | Lumenal | ||||
Sequence: KSSENVPDKVNVKLQHVFHYGLNEDSISYYRLDVAKKSVYAESESKLPLKMKKGYSVHLKDQSRDALTDYRYKSMKGIYSEANSPADLWEQEAIVIPDITDKETIYSLGKMSYNAYQKIPFDGDWLDLGPDWNITPPEGFGWEEDGLRGHVFSNDDNSTIIIAMKGTSIFGIGRGTSQKDRVNDNLLFSCCCARVSWAWSTVCGCYKNTYTCSQTCLEDEVQDDSRYYSASLDIFYSVKELYPDAQIWLTGHSLGGATAALMGLSFGIPTVTFEAPGDRMAARRLHLPMPPGLPDEESLVWHFGHNADPIYLGKCTGPTSLCWAGGYAMESTCHTGQECLYDVVKDKGWHLSITHHRMQTVLNDVIDAYEKLPDCSHTPNCVDCYLWEFPDDDS |
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Impairs atg8-processing.
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 5 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000090370 | 1-424 | Putative lipase atg15 | |||
Sequence: MSQLLFLRRFFFLFCFIIRISCTGVFESVIKSSENVPDKVNVKLQHVFHYGLNEDSISYYRLDVAKKSVYAESESKLPLKMKKGYSVHLKDQSRDALTDYRYKSMKGIYSEANSPADLWEQEAIVIPDITDKETIYSLGKMSYNAYQKIPFDGDWLDLGPDWNITPPEGFGWEEDGLRGHVFSNDDNSTIIIAMKGTSIFGIGRGTSQKDRVNDNLLFSCCCARVSWAWSTVCGCYKNTYTCSQTCLEDEVQDDSRYYSASLDIFYSVKELYPDAQIWLTGHSLGGATAALMGLSFGIPTVTFEAPGDRMAARRLHLPMPPGLPDEESLVWHFGHNADPIYLGKCTGPTSLCWAGGYAMESTCHTGQECLYDVVKDKGWHLSITHHRMQTVLNDVIDAYEKLPDCSHTPNCVDCYLWEFPDDDS | ||||||
Glycosylation | 187 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Subunit
Binds to both phosphatidylinositol (PI) and phosphatidylinositol 3,5-bisphosphate (PIP2).
Protein-protein interaction databases
Structure
Family & Domains
Sequence similarities
Belongs to the AB hydrolase superfamily. Lipase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length424
- Mass (Da)47,938
- Last updated1998-01-01 v1
- Checksum8B8BA13645C5097E
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CU329670 EMBL· GenBank· DDBJ | CAB16887.1 EMBL· GenBank· DDBJ | Genomic DNA |