O13597 · ERG24_SEPLY

Function

function

Reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol.

Catalytic activity

Pathway

Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 2/6.

Features

Showing features for binding site.

151250100150200250300350400450500
TypeIDPosition(s)Description
Binding site380NADP+ (UniProtKB | ChEBI)
Binding site384NADP+ (UniProtKB | ChEBI)
Binding site407NADP+ (UniProtKB | ChEBI)
Binding site412NADP+ (UniProtKB | ChEBI)
Binding site419-420NADP+ (UniProtKB | ChEBI)
Binding site484NADP+ (UniProtKB | ChEBI)
Binding site488-492NADP+ (UniProtKB | ChEBI)
Binding site499NADP+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular Functiondelta14-sterol reductase activity
Molecular FunctionNADP binding
Biological Processergosterol biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Delta(14)-sterol reductase
  • EC number
  • Alternative names
    • C-14 sterol reductase
    • Sterol C14-reductase

Gene names

    • Name
      ERG3

Organism names

Accessions

  • Primary accession
    O13597

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane27-47Helical
Transmembrane100-120Helical
Transmembrane140-160Helical
Transmembrane172-192Helical
Transmembrane242-262Helical
Transmembrane278-298Helical
Transmembrane324-344Helical
Transmembrane353-373Helical
Transmembrane418-438Helical
Transmembrane458-478Helical

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002074981-512Delta14-sterol reductase

Structure

Family & Domains

Sequence similarities

Belongs to the ERG4/ERG24 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    512
  • Mass (Da)
    57,578
  • Last updated
    1998-01-01 v1
  • Checksum
    169A756E60C0E963
MARTKATARKTVPAQQEAHGYEFGGPIGASLISFGLPIACYAFGFLCNDVSGCPPPSLLSPSKLFTPPTLSNKVPWQHALDTLAAEVGWPGWSGLINTEAVLGVFFWYGLSLLLWVLLPAHEVEGTELRTGGRLKYRFNACLSAVTIFVACAAGTIVRGPDFQVWTFINRNYIQLLTVNIIIAYALAIYVYLKSFEVKAGNTEQRELAAGGHSGHILYDWYMGRELNPRITIPFIGEVDIKSFMELRPGMIGWVLLDLAFAAKQYKSYGYITDSMRKWTPLLLGIHVLTIHPVIVIISQSVYVFDALYMEPAILTTMDLTTDGFGFMLSFGDLVWVPFIYSIQAKYLSVHPVALGPLYVALILTIQATGYYIFRATNNDKNIFRTNPNDPKVAHLKYIETGTGSRLLTTGWWGTARHINYLGDWLMSWSYCLPTLAAGYKLTPTILFENSRLVSTDGMKGAGIPITYFYMLYFAILLIHRERRDEAKCRRKYGAHWEKYCQIVRWRILPGVY

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
Y14389
EMBL· GenBank· DDBJ
CAA74747.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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