O13395 · CHS6_USTMA

Function

function

Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer (PubMed:14990260, PubMed:16314447).
Plays a crucial role during infection and allows th fungus to overcome the resistance of the plant that checks growth of the pathogen and eventually eliminates it (PubMed:14990260).

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell periphery
Cellular Componentcell septum
Cellular Componentcytoplasmic vesicle membrane
Cellular Componentplasma membrane
Molecular Functionchitin synthase activity
Biological Processcell wall organization
Biological Processchitin biosynthetic process

Keywords

Enzyme and pathway databases

Protein family/group databases

    • GT2Glycosyltransferase Family 2

Names & Taxonomy

Protein names

  • Recommended name
    Chitin synthase 6
  • EC number
  • Alternative names
    • Chitin-UDP acetyl-glucosaminyl transferase 6
    • Class-V chitin synthase 6

Gene names

    • Name
      CHS6
    • ORF names
      UMAG_10367

Organism names

Accessions

  • Primary accession
    O13395
  • Secondary accessions
    • A0A0D1CR95
    • Q4PA11

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Cytoplasmic vesicle membrane
; Multi-pass membrane protein
Note: A constitutive cytoplasmic pool is present that localizes to intracellular microvesicles termed chitosomes. Chitosomes constitute a separate secretory route distinct from the typical secretory pathway and serve as a vehicle for delivering the enzyme to the sites on the cell surface where polysaccharide sythesis takes place. Localizes to septa of yeast-like cells and to the basal septum separating the living tip cell from the vacuolated part in hyphae. Also localizes to the growing bud tip in yeast-like cells and in a tip-ward gradient at the hyphal apex.

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane108-128Helical
Transmembrane374-394Helical
Transmembrane762-782Helical
Transmembrane795-815Helical
Transmembrane822-842Helical

Keywords

Phenotypes & Variants

Disruption phenotype

Does not effect the dimorphic transition in vitro, mating, nor growth rate. Leads to important alterations in cell morphology, particularly at the mycelial stage, and in the staining pattern with calcofluor white (PubMed:14990260).
Reduces levels of chitin synthase activity and subsequent chitin content (PubMed:14990260).
Almost completely abolishes virulence to maize (PubMed:14990260).

Miscellaneous

PTM/Processing

Features

Showing features for chain, glycosylation.

Type
IDPosition(s)Description
ChainPRO_00001937241-1180Chitin synthase 6
Glycosylation737N-linked (GlcNAc...) asparagine

Keywords

PTM databases

Expression

Induction

Expression is slightly lower in the yeast form than in the mycelium and shows a maximal expression in the log phase at about 14-18 h of incubation (PubMed:22538468).
Highly expressed during the chlorosis stage and the stage of white tumors of plant infection (PubMed:22538468).

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1118-1175DEK-C

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,180
  • Mass (Da)
    130,623
  • Last updated
    2007-01-09 v2
  • Checksum
    72974D483D5F684B
MSTKDAHDPFATPLETITHDPLAETAGLKADYDKRAYGEANPALMGTLEKDDMANRPIDAVEEVPTTSIRKWWVRLTWFTTWWIPSFVLSKCGGMKRPDVQMAWREKFTICAIIFWLCAIILFYIIAFGRLLCPDYDKAWNLSQLSQHAGENDYYAAVRGTVYDFSKFYKGDHSDITNLQTSSDLMLQLAGQDLTGYFPVPLSVGCQSLVSDTSLALMPTANNTPLISQAIHTSGPLQGDTSSKLHDINWYPDRFLPFVKKLRKGYYVYSKKDLANQGQWRNWAVIHGKVYDLSNYLNTVSTYQTNPAYSFLDSSIVSLFKSQAGSDITADFEDAMSTFNQTYRGATQACLDNVFYVGRTDFRDTARCEVQNYLLLAFSVLLVTTVLAKFIAALQLGTKRSPEQQDKFVICQVPCYTEGEEELRKTIDSLAGLEYDDKRKLLFLICDGMIVGSGNDRSTPRIVLDILGVDPKIDPEPLMFKSVAEGSKQLNYAKVYSGLYEFEGHVVPYIVVVKVGRPSERSRPGNRGKRDSQILLMRYLNRVHFDAPMFPLELEIYHQMKNVIGIDPAFYEYILMVDADTRVEADGLNRLVANCADDSSIIAICGETTLDNAEGSWWTMIQVYEYYISHHLSKAFESLFGSVTCLPGCFSLYRIRSSDKGRPLFISNRIIDDYSENRVDTLHKKNLLHLGEDRYLTTLVLKNFPSFRTKFVPDAKALTSAPDRFGVLLSQRRRWINSTVHNLAELVLMPELCGFCLFSMRFIVFIDLLGTVILPATAVYLVYLIVTVATKSAPIPYISIAMIAAVYGLQAILFLLKRQWQYIGWLVIYILAYPVFSFFLPIYSFWHMDDFSWGNTRIVVGEKGNKKIVAGTDDEPYDDTMIPLKRFSEYQREVWEEEAAAPSMRSGMTGASGPFGNSQAILHSGPPSVYRAGGSAYAGSVAGSDYGAGLGDYYQNTNVLQKPAHSRQTSAAALSQMGGSQAASMMFGTGTPSVYGMAGMGSMYGMPGSSASMYGLPNPMMNTTASMYGLPPMLANPLGANHSPAHSDIGVSMPVSQQNTGGSHIWAQPPEAATVAANSGRGSGMQARPVSTLSALNATNPFGVTAVARALAVNEASDPTDEEIKSAVQTYLANQPSLMNVTKRSVREALVAAFPNAELSYKKSMINKAIDDTLSGGAQA

Sequence caution

The sequence AAB84285.1 differs from that shown. Reason: Frameshift

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict196in Ref. 1; AAB84285

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF030554
EMBL· GenBank· DDBJ
AAB84285.1
EMBL· GenBank· DDBJ
Genomic DNA Frameshift
CM003146
EMBL· GenBank· DDBJ
KIS69073.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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