O13395 · CHS6_USTMA
- ProteinChitin synthase 6
- GeneCHS6
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1180 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer (PubMed:14990260, PubMed:16314447).
Plays a crucial role during infection and allows th fungus to overcome the resistance of the plant that checks growth of the pathogen and eventually eliminates it (PubMed:14990260).
Plays a crucial role during infection and allows th fungus to overcome the resistance of the plant that checks growth of the pathogen and eventually eliminates it (PubMed:14990260).
Catalytic activity
- [(1->4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1->4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H+This reaction proceeds in the forward direction.
[(1→4)-N-acetyl-β-D-glucosaminyl](n) RHEA-COMP:9593 + CHEBI:57705 = [(1→4)-N-acetyl-β-D-glucosaminyl](n+1) RHEA-COMP:9595 + CHEBI:58223 + CHEBI:15378
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cell periphery | |
Cellular Component | cell septum | |
Cellular Component | cytoplasmic vesicle membrane | |
Cellular Component | plasma membrane | |
Molecular Function | chitin synthase activity | |
Biological Process | cell wall organization | |
Biological Process | chitin biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameChitin synthase 6
- EC number
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Fungi > Dikarya > Basidiomycota > Ustilaginomycotina > Ustilaginomycetes > Ustilaginales > Ustilaginaceae > Ustilago
Accessions
- Primary accessionO13395
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Cytoplasmic vesicle membrane ; Multi-pass membrane protein
Note: A constitutive cytoplasmic pool is present that localizes to intracellular microvesicles termed chitosomes. Chitosomes constitute a separate secretory route distinct from the typical secretory pathway and serve as a vehicle for delivering the enzyme to the sites on the cell surface where polysaccharide sythesis takes place. Localizes to septa of yeast-like cells and to the basal septum separating the living tip cell from the vacuolated part in hyphae. Also localizes to the growing bud tip in yeast-like cells and in a tip-ward gradient at the hyphal apex.
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 108-128 | Helical | |||
Transmembrane | 374-394 | Helical | |||
Transmembrane | 762-782 | Helical | |||
Transmembrane | 795-815 | Helical | |||
Transmembrane | 822-842 | Helical | |||
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Does not effect the dimorphic transition in vitro, mating, nor growth rate. Leads to important alterations in cell morphology, particularly at the mycelial stage, and in the staining pattern with calcofluor white (PubMed:14990260).
Reduces levels of chitin synthase activity and subsequent chitin content (PubMed:14990260).
Almost completely abolishes virulence to maize (PubMed:14990260).
Reduces levels of chitin synthase activity and subsequent chitin content (PubMed:14990260).
Almost completely abolishes virulence to maize (PubMed:14990260).
Miscellaneous
PTM/Processing
Features
Showing features for chain, glycosylation.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000193724 | 1-1180 | Chitin synthase 6 | ||
Glycosylation | 737 | N-linked (GlcNAc...) asparagine | |||
Keywords
- PTM
PTM databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 1118-1175 | DEK-C | |||
Sequence similarities
Belongs to the chitin synthase family. Class V subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,180
- Mass (Da)130,623
- Last updated2007-01-09 v2
- Checksum72974D483D5F684B
Sequence caution
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Sequence conflict | 196 | in Ref. 1; AAB84285 | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF030554 EMBL· GenBank· DDBJ | AAB84285.1 EMBL· GenBank· DDBJ | Genomic DNA | Frameshift | |
CM003146 EMBL· GenBank· DDBJ | KIS69073.1 EMBL· GenBank· DDBJ | Genomic DNA |