O13394 · CHS5_USTMA

Function

function

Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell periphery
Cellular Componentcell septum
Cellular Componentcytoplasmic vesicle membrane
Cellular Componentplasma membrane
Molecular Functionchitin synthase activity
Biological Processcell wall organization
Biological Processchitin biosynthetic process

Keywords

Enzyme and pathway databases

Protein family/group databases

    • GT2Glycosyltransferase Family 2

Names & Taxonomy

Protein names

  • Recommended name
    Chitin synthase 5
  • EC number
  • Alternative names
    • Chitin-UDP acetyl-glucosaminyl transferase 5
    • Class-IV chitin synthase 5

Gene names

    • Name
      CHS5
    • ORF names
      UMAG_10277

Organism names

Accessions

  • Primary accession
    O13394
  • Secondary accessions
    • A0A0D1DZZ4
    • Q4PBE4

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Cytoplasmic vesicle membrane
; Multi-pass membrane protein
Note: A constitutive cytoplasmic pool is present that localizes to intracellular microvesicles termed chitosomes. Chitosomes constitute a separate secretory route distinct from the typical secretory pathway and serve as a vehicle for delivering the enzyme to the sites on the cell surface where polysaccharide sythesis takes place (By similarity).
Localizes to septa of yeast-like cells and to the basal septum separating the living tip cell from the vacuolated part in hyphae. Also localizes to the growing bud tip in yeast-like cells and in a tip-ward gradient at the hyphal apex

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-326Cytoplasmic
Transmembrane327-347Helical
Topological domain348-364Extracellular
Transmembrane365-385Helical
Topological domain386-624Cytoplasmic
Transmembrane625-645Helical
Topological domain646-1176Extracellular
Transmembrane1177-1197Helical
Topological domain1198-1202Cytoplasmic
Transmembrane1203-1223Helical
Topological domain1224-1227Extracellular
Transmembrane1228-1248Helical
Topological domain1249-1609Cytoplasmic

Keywords

Phenotypes & Variants

Miscellaneous

PTM/Processing

Features

Showing features for chain, glycosylation.

TypeIDPosition(s)Description
ChainPRO_00001937231-1609Chitin synthase 5
Glycosylation654N-linked (GlcNAc...) asparagine
Glycosylation1015N-linked (GlcNAc...) asparagine
Glycosylation1144N-linked (GlcNAc...) asparagine

Keywords

PTM databases

Expression

Induction

Expression is slightly lower in the yeast form than in the mycelium and shows a maximal expression in the log phase at about 14-18 h of incubation.

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region1-188Disordered
Compositional bias20-55Pro residues
Compositional bias59-80Polar residues
Compositional bias97-134Polar residues
Compositional bias145-168Polar residues
Compositional bias170-188Basic and acidic residues
Region248-280Disordered
Region294-320Disordered
Compositional bias303-317Basic and acidic residues
Region729-767Disordered
Compositional bias743-765Polar residues
Compositional bias1354-1377Polar residues
Region1354-1381Disordered
Region1399-1609Disordered
Compositional bias1435-1449Polar residues
Compositional bias1504-1518Polar residues
Compositional bias1526-1555Polar residues
Compositional bias1574-1593Polar residues
Compositional bias1594-1609Pro residues

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,609
  • Mass (Da)
    176,298
  • Last updated
    2015-09-16 v3
  • Checksum
    D37C3155BB515528
MNPFESLPDAARPAQGTRPNRSDGPPPLPPLTIPGSTGRPQNPIFSPPPNLHHILPPGYLPQQQQQQQQQQQQQQQRSQQPFFSPPPPDAMSPPLGSHQAYLNSTSSQPTQRLPGISFQEPQRMPVQRSGPSRDSVKSYGDDKRSINDPNSSSTALTQVNSLDPESGFSAHNDTFRRKKSLVRPDRERMDPSHRQWYYRNHAAHMDVMAASGGRVGYMPSTTGHLPQHGAAPHGSGMAGIVGPGGGLSGLGVTGPTNVPPGGLGRAPPLRRGKSLLGRDEDQVETGINVLKRGVSLRRKQSKSGNKPSKEVPRDLGESKTSRIAPGPVGGWMIYCYILTICCPGPFLRIFGIRTPEQQRAWREKMGLIGIITLIMAAVGFLTFGFTQTVCGQQPDRYTLGTIDVGSMTFNGYDYSFDGFIHPQVGPFGADTIYNRTNPIYSEPWSSGGQDGSLLFQKIGAACTGIISNRAGGAQPERYFDCTLVRQDGKGGYANSTMPMCHTGSIVDQFNDGAQPRNSVLKKRGQVSLQWNNVTDPARNLAVYRGSVLDLNRLNNLTTGLSYPELYDTLKRRNDSWAGRDVTSAVMRQRLEREFQCLEQITRVGFIDSETIGCVASKVELYLSLVFIIGVVAIKFFMAVMFGWFISWRLGNYANETYEQRMKRAAEIEQWSDDIYRPAPAGYRPNARKHKSFLPAKSRFSVADPLSLKSGSRAPMPLSEKRMTRASRLGVASPLGGSPPGSPSVAGGRSSASLAPAHSRRSSFSGSPAEGAMGVCPFPLHNTIPQPGPDYRPFGFQLAHSICLVTAYSESFEGLRTTLDSLATTDYPNSHKLLLVIADGIVKGAGSDISTPDICLSMMKDLVIPAEEVEGNSYVAIADGYKRHNMCKIYAGFYDYDDETVERSKQQRVPMILVAKCGTPLEADSAKPGNRGKRDSQVLLMAFMQKVMFDERMTAFEYEFFNSIWRVTGVSPDNYEIVLCVDADTKVFPDSLSRMVACMVEDPEIMGLCGETKIANKSETWVTMIQVFEYYISHHQTKAFEACFGGVTCLPGCFSAYRIKAPKGPHGYWVPILANPDIVEHYSENVVDTLHKKNLLLLGEDRYLTTLMLKTFPKRKMMFVPQAVCKTIVPDTFRILLSQRRRWINSTVHNLFELVMVNDLCGTFCFSMRFVVFMELTGTLVLPAAIAFTLYVVVQAFLPNVPTPTIPLILLALILGLPGILIVVTSRKIAYVGWMLIYLLSLPIWNFVLPLYAYWHMDDFSWGATRVVQGENKKDNHGDADGKFDPSHIVMKRWAEFERERRWKSGTHSRDSTYDVVQRTGSPERAGSTRYSVVSSDTFHSSPFGQHDQFGRALPNAMSSSSASQFGPDVSEVSHSKSPSGARARLDAVPLLELPAPLATDAKHRSGASPTGTVVVPRPRATSPAPLPHNSGHPALGSVSAFSPTQHSAGRLPTLPGAATYEAYPHTDAADEERRPMIGSTSSSPDPEPRRYIGPDAGVRHGNVSTEQRYPTVSESAYPMQAYTAEPETDGSASPTPAQQGFNAANSNQQTRPLTRGFSLVDDGPVASAQGVRQVQRGARRSQMPNSAASPPPANRTGNLPPGAAPPSFD

Sequence caution

The sequence AAB84284.1 differs from that shown. Reason: Erroneous gene model prediction
The sequence AAB84284.1 differs from that shown. Reason: Frameshift

Features

Showing features for compositional bias, sequence conflict.

TypeIDPosition(s)Description
Compositional bias20-55Pro residues
Sequence conflict54in Ref. 1; AAB84284
Compositional bias59-80Polar residues
Sequence conflict75-76in Ref. 1; AAB84284
Compositional bias97-134Polar residues
Compositional bias145-168Polar residues
Compositional bias170-188Basic and acidic residues
Compositional bias303-317Basic and acidic residues
Compositional bias743-765Polar residues
Compositional bias1354-1377Polar residues
Compositional bias1435-1449Polar residues
Compositional bias1504-1518Polar residues
Compositional bias1526-1555Polar residues
Compositional bias1574-1593Polar residues
Compositional bias1594-1609Pro residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF030553
EMBL· GenBank· DDBJ
AAB84284.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
CM003145
EMBL· GenBank· DDBJ
KIS69221.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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