O13134 · S4A4_AMBTI
- ProteinElectrogenic sodium bicarbonate cotransporter 1
- GeneSLC4A4
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1035 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Electrogenic sodium/bicarbonate cotransporter with a Na+:HCO3- stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH.
Catalytic activity
- 2 hydrogencarbonate(out) + Na+(out) = 2 hydrogencarbonate(in) + Na+(in)
2 hydrogencarbonate (out)CHEBI:17544+ Na+ (out)CHEBI:29101= 2 hydrogencarbonate (in)CHEBI:17544+ Na+ (in)CHEBI:29101 - 3 hydrogencarbonate(out) + Na+(out) = 3 hydrogencarbonate(in) + Na+(in)
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | basolateral plasma membrane | |
Molecular Function | monoatomic anion transmembrane transporter activity | |
Molecular Function | sodium:bicarbonate symporter activity | |
Molecular Function | solute:inorganic anion antiporter activity | |
Biological Process | regulation of intracellular pH |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameElectrogenic sodium bicarbonate cotransporter 1
- Short namesSodium bicarbonate cotransporter
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Caudata > Salamandroidea > Ambystomatidae > Ambystoma
Accessions
- Primary accessionO13134
Subcellular Location
UniProt Annotation
GO Annotation
Basolateral cell membrane ; Multi-pass membrane protein
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane, intramembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Topological domain | 1-421 | Cytoplasmic | |||
Transmembrane | 422-446 | Helical; Name=1 | |||
Topological domain | 447-456 | Extracellular | |||
Transmembrane | 457-475 | Helical; Name=2 | |||
Topological domain | 476 | Cytoplasmic | |||
Transmembrane | 477-497 | Discontinuously helical; Name=3 | |||
Topological domain | 498-505 | Extracellular | |||
Transmembrane | 506-526 | Helical; Name=4 | |||
Topological domain | 527-540 | Cytoplasmic | |||
Transmembrane | 541-564 | Helical; Name=5 | |||
Topological domain | 565-648 | Extracellular | |||
Transmembrane | 649-666 | Helical; Name=6 | |||
Topological domain | 667-681 | Cytoplasmic | |||
Transmembrane | 682-701 | Helical; Name=7 | |||
Topological domain | 702-735 | Extracellular | |||
Transmembrane | 736-763 | Helical; Name=8 | |||
Topological domain | 764-775 | Cytoplasmic | |||
Transmembrane | 776-792 | Helical; Name=9 | |||
Topological domain | 793 | Extracellular | |||
Transmembrane | 794-811 | Discontinuously helical; Name=10 | |||
Topological domain | 812-833 | Cytoplasmic | |||
Transmembrane | 834-850 | Helical; Name=11 | |||
Topological domain | 851-857 | Extracellular | |||
Transmembrane | 858-874 | Helical; Name=12 | |||
Topological domain | 875-916 | Cytoplasmic | |||
Intramembrane | 917-942 | Discontinuously helical | |||
Topological domain | 943-1035 | Cytoplasmic | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, glycosylation.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000079232 | 1-1035 | Electrogenic sodium bicarbonate cotransporter 1 | ||
Glycosylation | 591 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 596 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 609 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 617 | N-linked (GlcNAc...) asparagine | |||
Keywords
- PTM
PTM databases
Expression
Tissue specificity
Expressed in kidney and to a lower extent in bladder, brain, intestine, large intestine and eye.
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for compositional bias, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 192-217 | Polar residues | |||
Region | 192-222 | Disordered | |||
Region | 348-389 | Disordered | |||
Compositional bias | 968-995 | Basic and acidic residues | |||
Region | 968-1035 | Disordered | |||
Compositional bias | 1009-1035 | Basic and acidic residues | |||
Sequence similarities
Belongs to the anion exchanger (TC 2.A.31) family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,035
- Mass (Da)116,108
- Last updated1997-07-01 v1
- Checksum3CF50B31275A81AF
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 192-217 | Polar residues | |||
Compositional bias | 968-995 | Basic and acidic residues | |||
Compositional bias | 1009-1035 | Basic and acidic residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF001958 EMBL· GenBank· DDBJ | AAB61339.1 EMBL· GenBank· DDBJ | mRNA |