O13134 · S4A4_AMBTI

Function

function

Electrogenic sodium/bicarbonate cotransporter with a Na+:HCO3- stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH.

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentbasolateral plasma membrane
Molecular Functionmonoatomic anion transmembrane transporter activity
Molecular Functionsodium:bicarbonate symporter activity
Molecular Functionsolute:inorganic anion antiporter activity
Biological Processregulation of intracellular pH

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Electrogenic sodium bicarbonate cotransporter 1
  • Short names
    Sodium bicarbonate cotransporter
  • Alternative names
    • Na(+)/HCO3(-) cotransporter
    • Solute carrier family 4 member 4

Gene names

    • Name
      SLC4A4
    • Synonyms
      NBC, NBCE1

Organism names

Accessions

  • Primary accession
    O13134

Subcellular Location

Basolateral cell membrane
; Multi-pass membrane protein
Cell membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, transmembrane, intramembrane.

Type
IDPosition(s)Description
Topological domain1-421Cytoplasmic
Transmembrane422-446Helical; Name=1
Topological domain447-456Extracellular
Transmembrane457-475Helical; Name=2
Topological domain476Cytoplasmic
Transmembrane477-497Discontinuously helical; Name=3
Topological domain498-505Extracellular
Transmembrane506-526Helical; Name=4
Topological domain527-540Cytoplasmic
Transmembrane541-564Helical; Name=5
Topological domain565-648Extracellular
Transmembrane649-666Helical; Name=6
Topological domain667-681Cytoplasmic
Transmembrane682-701Helical; Name=7
Topological domain702-735Extracellular
Transmembrane736-763Helical; Name=8
Topological domain764-775Cytoplasmic
Transmembrane776-792Helical; Name=9
Topological domain793Extracellular
Transmembrane794-811Discontinuously helical; Name=10
Topological domain812-833Cytoplasmic
Transmembrane834-850Helical; Name=11
Topological domain851-857Extracellular
Transmembrane858-874Helical; Name=12
Topological domain875-916Cytoplasmic
Intramembrane917-942Discontinuously helical
Topological domain943-1035Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain, glycosylation.

Type
IDPosition(s)Description
ChainPRO_00000792321-1035Electrogenic sodium bicarbonate cotransporter 1
Glycosylation591N-linked (GlcNAc...) asparagine
Glycosylation596N-linked (GlcNAc...) asparagine
Glycosylation609N-linked (GlcNAc...) asparagine
Glycosylation617N-linked (GlcNAc...) asparagine

Keywords

PTM databases

Expression

Tissue specificity

Expressed in kidney and to a lower extent in bladder, brain, intestine, large intestine and eye.

Interaction

Subunit

Homodimer.

Structure

Family & Domains

Features

Showing features for compositional bias, region.

Type
IDPosition(s)Description
Compositional bias192-217Polar residues
Region192-222Disordered
Region348-389Disordered
Compositional bias968-995Basic and acidic residues
Region968-1035Disordered
Compositional bias1009-1035Basic and acidic residues

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,035
  • Mass (Da)
    116,108
  • Last updated
    1997-07-01 v1
  • Checksum
    3CF50B31275A81AF
MSSEKECLENMLNGYAESGRVLSRTSLVINQAVNRSIFTSTVSPAAERIRFILGEEDDSPAPPQLFTELDELLAVDGQEMEWKETARWIKFEEKVEQGGERWSKPHVATLSLHSLFELRTCIEKGTILLDLEATSLPQIVEIVINNQIELGLLKADMKENVTRTLLRKHRHQTKKSNLRSLADIGKTVSSASRLFSTPDNGSPTMTHRNLTSTSLNDVSDKPDKEQLKNKFMKKLPRDAEASNVLVGEVDFLESPFIAFVRLQQAVMLGSLTEVPVPTRFLFILLGPKGKAKSYHEIGRSIATLMSDEVFHDIAYKAKNREDLIAGIDEFLDEVIVLPLGEWDPTIRIEPPKSLPSSDKRKNMYSGGDNLQMNGDAPHDDGGGGHGDSEELQRTGRFCGGLIKDIQRKAPFFASDFYDALSIQSLSAILFIYLGTVTNAITFGGLLGDATENMQGVLESFLGTAVSGAVFCLFGGQPLTILSSTGPVLVFERLLFNFSKDNDFDYLEFRLWIGLWSAFQCLILVATDASFLVKYFTRFTEEGFSSLISFIFIYDAFKKMIKLADYYPINSHFKVDYITQYSCACFPPEPANSSWFNMTTAATTTQFLTNASTDMAYNGTIDWSLLSKKECLKYGGLLVGSNCKYVPDITLMSFILFLGTYTCSMALKKFKTSRYFPTTARKLISDFAIILSILIFCGLDALLGVDTPKLIVPSEFKPTSPNRGWFVPPFGGNPWWVYLAAAIPALLVTILIFMDQQITGVIVNRKEHKLKKGAGYHLDLFWVAILMVVCSFMALPWYVAATVISIAHIDSLKMETETSAPGEQPKFLGVREQRVTGTVVFLLTGLSVFMAPILKFIPMPVLYGVFLYMGVASLNGVQFMDRLKLLLMPPKYQPDFIYLRHVPLRRVHLFTFLQVVCLAMLWILKSTVAAIIFPVMILALVAVRKAMDYFFSQHDLSFLDDVIPEKDKKKKEDEKKKKKKKGSIDSDVEDSDCPYPEKVPSIKIPMDIMEKEPFLIDSKPSDRENSPTFLERHTSC

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias192-217Polar residues
Compositional bias968-995Basic and acidic residues
Compositional bias1009-1035Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF001958
EMBL· GenBank· DDBJ
AAB61339.1
EMBL· GenBank· DDBJ
mRNA

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