O13055 · GNAI2_ORYLA

Function

function

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division (By similarity).

Features

Showing features for binding site.

135550100150200250300350
TypeIDPosition(s)Description
Binding site40-47GTP (UniProtKB | ChEBI)
Binding site47Mg2+ (UniProtKB | ChEBI)
Binding site176-182GTP (UniProtKB | ChEBI)
Binding site182Mg2+ (UniProtKB | ChEBI)
Binding site201-205GTP (UniProtKB | ChEBI)
Binding site270-273GTP (UniProtKB | ChEBI)
Binding site327GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcentrosome
Cellular Componentcytoplasm
Cellular Componentheterotrimeric G-protein complex
Cellular Componentmidbody
Cellular Componentplasma membrane
Molecular FunctionG protein-coupled receptor binding
Molecular FunctionG-protein beta/gamma-subunit complex binding
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Molecular Functionmetal ion binding
Biological Processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Biological Processcell division
Biological ProcessG protein-coupled adenosine receptor signaling pathway
Biological Processgamma-aminobutyric acid signaling pathway

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Guanine nucleotide-binding protein G(i) subunit alpha-2
  • Alternative names
    • Adenylate cyclase-inhibiting G alpha protein
    • Gi alpha c
    • Gi2 subunit alpha

Gene names

    • Name
      gnai2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Atherinomorphae > Beloniformes > Adrianichthyidae > Oryziinae > Oryzias

Accessions

  • Primary accession
    O13055

Proteomes

PTM/Processing

Features

Showing features for initiator methionine, lipidation, chain.

Type
IDPosition(s)Description
Initiator methionine1Removed
Lipidation2N-myristoyl glycine
ChainPRO_00002036842-355Guanine nucleotide-binding protein G(i) subunit alpha-2
Lipidation3S-palmitoyl cysteine

Keywords

Expression

Gene expression databases

Interaction

Subunit

G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain32-355G-alpha
Region35-48G1 motif
Region174-182G2 motif
Region197-206G3 motif
Region266-273G4 motif
Region325-330G5 motif

Sequence similarities

Belongs to the G-alpha family. G(i/o/t/z) subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    355
  • Mass (Da)
    40,993
  • Last updated
    2007-01-23 v3
  • MD5 Checksum
    139465A7F7F359997BED8EC7BEEEF765
MGCTVSQEDKAAADRSKMIDKNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEDGYSEDECKQYRAVVYSNTVQSIMAIIKAMTILHLDYERPEREEDAKRLFKMAAEAEERGDLPEELANIIKDLWADSGIQHCLTRAREYQLNDSAAYYLKDLERISKPDYIPTQQDVLRTRVKTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVAMSAYDLVLAEDEEMNRMHESMKLFDSICNNKWFTETSIILFLNKKDLFEQKIAHSPLTICFPEYEGPNTYQEAQAYIQTKFEDLNKKKETKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB001742
EMBL· GenBank· DDBJ
BAA20073.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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