O13055 · GNAI2_ORYLA
- ProteinGuanine nucleotide-binding protein G(i) subunit alpha-2
- Genegnai2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids355 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division (By similarity).
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 40-47 | GTP (UniProtKB | ChEBI) | |||
Binding site | 47 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 176-182 | GTP (UniProtKB | ChEBI) | |||
Binding site | 182 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 201-205 | GTP (UniProtKB | ChEBI) | |||
Binding site | 270-273 | GTP (UniProtKB | ChEBI) | |||
Binding site | 327 | GTP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | centrosome | |
Cellular Component | cytoplasm | |
Cellular Component | heterotrimeric G-protein complex | |
Cellular Component | midbody | |
Cellular Component | plasma membrane | |
Molecular Function | G protein-coupled receptor binding | |
Molecular Function | G-protein beta/gamma-subunit complex binding | |
Molecular Function | GTP binding | |
Molecular Function | GTPase activity | |
Molecular Function | metal ion binding | |
Biological Process | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway | |
Biological Process | cell division | |
Biological Process | G protein-coupled adenosine receptor signaling pathway | |
Biological Process | gamma-aminobutyric acid signaling pathway |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameGuanine nucleotide-binding protein G(i) subunit alpha-2
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Atherinomorphae > Beloniformes > Adrianichthyidae > Oryziinae > Oryzias
Accessions
- Primary accessionO13055
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Features
Showing features for initiator methionine, lipidation, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Initiator methionine | 1 | Removed | |||
Lipidation | 2 | N-myristoyl glycine | |||
Chain | PRO_0000203684 | 2-355 | Guanine nucleotide-binding protein G(i) subunit alpha-2 | ||
Lipidation | 3 | S-palmitoyl cysteine | |||
Keywords
- PTM
Expression
Gene expression databases
Interaction
Subunit
G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 32-355 | G-alpha | |||
Region | 35-48 | G1 motif | |||
Region | 174-182 | G2 motif | |||
Region | 197-206 | G3 motif | |||
Region | 266-273 | G4 motif | |||
Region | 325-330 | G5 motif | |||
Sequence similarities
Belongs to the G-alpha family. G(i/o/t/z) subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length355
- Mass (Da)40,993
- Last updated2007-01-23 v3
- MD5 Checksum139465A7F7F359997BED8EC7BEEEF765
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB001742 EMBL· GenBank· DDBJ | BAA20073.1 EMBL· GenBank· DDBJ | mRNA |