O13023 · HHEX_XENLA

Function

function

Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. Regulates the differentiation of both endothelial and blood cells (By similarity).
Probably plays a role in the proliferation of vascular endothelial cells during blood vessel development. Establishes anterior identity at two levels; acts early to enhance canonical wnt-signaling by repressing expression of tle4, and acts later to inhibit nodal-signaling by directly targeting nodal/nr1 and nodal2/nr2. May play a role in liver development. Induces heart development

Features

Showing features for dna binding.

127220406080100120140160180200220240260
TypeIDPosition(s)Description
DNA binding137-196Homeobox

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Functionsequence-specific DNA binding
Biological Processanterior/posterior pattern specification
Biological Processembryonic hemopoiesis
Biological Processheart development
Biological Processliver development
Biological Processnegative regulation of DNA-templated transcription
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processpositive regulation of Wnt signaling pathway
Biological Processvasculogenesis
Biological ProcessWnt signaling pathway

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Hematopoietically-expressed homeobox protein hhex
  • Short names
    Homeobox protein hex; XHex
  • Alternative names
    • Hhex-A protein

Gene names

    • Name
      hhex
    • Synonyms
      hex
      , hhex-a

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Pipoidea > Pipidae > Xenopodinae > Xenopus > Xenopus

Accessions

  • Primary accession
    O13023

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003262201-272Hematopoietically-expressed homeobox protein hhex

Expression

Tissue specificity

First expressed in the dorsal endomesoderm of the gastrula stage embryo. The dorsal endomesoderm contributes to forming the embryonic liver, and expression continues in the liver throughout development. Also expressed in precursors of the developing thyroid gland, and beginning at the tailbud stage, expressed in the ventral region of the head. Also transiently expressed in the endothelial layer of developing vascular tissues of the embryo, beginning at the tailbud stages.

Induction

By maternal wnt-beta-catenin signaling and tgf-beta signaling.

Developmental stage

Expressed zygotically. During gastrulation, expression levels rise rapidly to peak at about stage 10.5. Following gastrulation, levels decrease slightly and then increase again during early tailbud stages, with expression continuing throughout embryonic development.

Gene expression databases

    • 373590Expressed in liver and 15 other cell types or tissues

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region222-272Disordered
Compositional bias234-250Polar residues

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    272
  • Mass (Da)
    30,576
  • Last updated
    1997-07-01 v1
  • Checksum
    15FC2FDBBCAFFF6E
MQYQHPSSSALGLSVPLFAPTPLQHPTPFYIDDILGRNSASNGTPALPTPTLPSPNSSFTSLVATYRTPIYEPTPIHPAFTHPGAALAASYGASTYASPLYPFSRPVSDYTHALIRHDSLGKPLLWSPFIQRPLHKRKGGQVRFSNDQTIELEKKFETQKYLSPPERKRLAKMLQLSERQVKTWFQNRRAKWRRLKQENPQGNKKDETESLENICEESQERCLSAEQKSRESSLDDPTSSPTSQGNLDSEVSDDSDQEVDIEGDKGYYNCAH

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias234-250Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U94837
EMBL· GenBank· DDBJ
AAB82335.1
EMBL· GenBank· DDBJ
mRNA
BC059320
EMBL· GenBank· DDBJ
AAH59320.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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