O13012 · ESR2_ANGJA
- ProteinEstrogen receptor beta
- Geneesr2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids573 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Binds estrogens with an affinity similar to that of ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner.
Features
Showing features for dna binding.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
DNA binding | 171-236 | Nuclear receptor | ||||
Sequence: CAVCHDYASGYHYGVWSCEGCKAFFKRSIQGHNGYICPATNQCTIDKNRRKSCQACRLRKCYEVGM |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | estrogen response element binding | |
Molecular Function | hormone binding | |
Molecular Function | nuclear estrogen receptor activity | |
Molecular Function | nuclear receptor activity | |
Molecular Function | steroid binding | |
Molecular Function | zinc ion binding | |
Biological Process | cellular response to estradiol stimulus | |
Biological Process | cellular response to estrogen stimulus | |
Biological Process | estrogen receptor signaling pathway |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameEstrogen receptor beta
- Short namesER-beta
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Anguilliformes > Anguillidae > Anguilla
Accessions
- Primary accessionO13012
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000053651 | 1-573 | Estrogen receptor beta | |||
Sequence: MAGSPGNELPLLQLQEVDSSKVGESGGSSGLLPTMYNGALPALSMESHAVCIPSPYTDSSHDYAALTFYSPPILSHGGPAVPESPAARQSLSPSLFWPAHGHHGHVSPLALHFQQPLVYREPAHSPWAEPKPLEHGQAQTSKLAGKRMAESEEGTSSVGGCFAGKGDMHFCAVCHDYASGYHYGVWSCEGCKAFFKRSIQGHNGYICPATNQCTIDKNRRKSCQACRLRKCYEVGMMKCGVRRERCTYRGARHRRMPHIRELAGTGGGARTQRRGEGVVPQTQEAQSSALTPEQLINRIIEAEPPEIYLMKELKKPFTEDSMMMSLTNLADKELVLMISWAKKIPGFVELDLSDQVHLLECCWLEVLMLGLMWRSVDHPGKLIFSPDLKLNRDEGSCVEGILEIFDMVLAATSRFRELKLQREEYVCLKAIILLNPNLCTTSSENREELESRNKLLHMLDSVTDALVWTIAKKGLTFQQQSARLAHLLMLLAHIRHLSNKGMEHLSNMKRKNVVPLYDLLLEMLDANTMHSSRMSASYSSQPSPWSQAAQSQPGPPPSCSGECPCPPKESSTI |
Expression
Tissue specificity
Liver.
Induction
By 17-beta-estradiol.
Interaction
Subunit
Binds DNA as a homodimer. Can form a heterodimer with ER-alpha.
Structure
Family & Domains
Features
Showing features for region, zinc finger, domain, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 15-170 | Modulating | ||||
Sequence: QEVDSSKVGESGGSSGLLPTMYNGALPALSMESHAVCIPSPYTDSSHDYAALTFYSPPILSHGGPAVPESPAARQSLSPSLFWPAHGHHGHVSPLALHFQQPLVYREPAHSPWAEPKPLEHGQAQTSKLAGKRMAESEEGTSSVGGCFAGKGDMHF | ||||||
Zinc finger | 171-191 | NR C4-type | ||||
Sequence: CAVCHDYASGYHYGVWSCEGC | ||||||
Zinc finger | 207-231 | NR C4-type | ||||
Sequence: CPATNQCTIDKNRRKSCQACRLRKC | ||||||
Domain | 291-527 | NR LBD | ||||
Sequence: TPEQLINRIIEAEPPEIYLMKELKKPFTEDSMMMSLTNLADKELVLMISWAKKIPGFVELDLSDQVHLLECCWLEVLMLGLMWRSVDHPGKLIFSPDLKLNRDEGSCVEGILEIFDMVLAATSRFRELKLQREEYVCLKAIILLNPNLCTTSSENREELESRNKLLHMLDSVTDALVWTIAKKGLTFQQQSARLAHLLMLLAHIRHLSNKGMEHLSNMKRKNVVPLYDLLLEMLDAN | ||||||
Compositional bias | 534-556 | Polar residues | ||||
Sequence: MSASYSSQPSPWSQAAQSQPGPP | ||||||
Region | 534-573 | Disordered | ||||
Sequence: MSASYSSQPSPWSQAAQSQPGPPPSCSGECPCPPKESSTI |
Domain
Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
Sequence similarities
Belongs to the nuclear hormone receptor family. NR3 subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length573
- Mass (Da)63,421
- Last updated1997-07-01 v1
- Checksum9C64C1D8D39ED4CC
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 534-556 | Polar residues | ||||
Sequence: MSASYSSQPSPWSQAAQSQPGPP |