O09100 · GATA2_MOUSE
- ProteinEndothelial transcription factor GATA-2
- GeneGata2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids480 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Publications for O09100
AML1(-/-) embryos do not express certain hematopoiesis-related gene transcripts including those of the PU.1 gene.
- CategoriesSequences, Expression
- SourceMGI: 95662
Normal reproductive and macrophage function in Pem homeobox gene-deficient mice.
- CategoriesExpression
- SourceMGI: 95662
Multistep signaling requirements for pituitary organogenesis in vivo.
- CategoriesFunction
- SourceMGI: 95662
Jak2 is essential for signaling through a variety of cytokine receptors.
- CategoriesFunction
- SourceMGI: 95662
Characterization of definitive lymphohematopoietic stem cells in the day 9 murine yolk sac.
- CategoriesSequences
- SourceMGI: 95662
Pit-1 and GATA-2 interact and functionally cooperate to activate the thyrotropin beta-subunit promoter.
- CategoriesSequences, Interaction
- SourceMGI: 95662
Transcription factor GATA-2 is required for proliferation/survival of early hematopoietic cells and mast cell formation, but not for erythroid and myeloid terminal differentiation.
- CategoriesFunction
- SourceMGI: 95662
- PubMed
- Europe PMC
- Blood 89:3636-3643 ()
Mapped toGATA-2 and GATA-3 regulate trophoblast-specific gene expression in vivo.
- CategoriesSequences, Expression
- SourceMGI: 95662
Initiation of murine embryonic erythropoiesis: a spatial analysis.
- CategoriesSequences, Expression
- SourceMGI: 95662
- PubMed
- Europe PMC
- Blood 89:1154-1164 ()
Mapped toGata2 maps to mouse chromosome 6.
- CategoriesFunction, Sequences
- SourceMGI: 95662
Thrombopoietin rescues in vitro erythroid colony formation from mouse embryos lacking the erythropoietin receptor.
- CategoriesFunction, Expression
- SourceMGI: 95662
PU. 1 is not essential for early myeloid gene expression but is required for terminal myeloid differentiation.
- CategoriesSequences
- SourceMGI: 95662
Abundant expression of transcription factor GATA-2 in proliferating but not in differentiated mast cells in tissues of mice: demonstration by in situ hybridization.
- CategoriesSequences, Expression
- SourceMGI: 95662
- PubMed
- Europe PMC
- Blood 87:993-998 ()
Mapped toAn early haematopoietic defect in mice lacking the transcription factor GATA-2.
- CategoriesFunction
- SourceMGI: 95662
Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene.
- CategoriesPhenotypes & Variants
- SourceMGI: 95662
PML::RARA and GATA2 proteins interact via DNA templates to induce aberrant self-renewal in mouse and human hematopoietic cells.
- AnnotationPML::RARA and GATA2 proteins interact via DNA templates to induce aberrant self-renewal in mouse and human hematopoietic cells.
- SourceGeneRif: 14461