O08934 · UNC4_MOUSE

  • Protein
    Homeobox protein unc-4 homolog
  • Gene
    Uncx
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

function

Transcription factor involved in somitogenesis and neurogenesis. Required for the maintenance and differentiation of particular elements of the axial skeleton. May act upstream of PAX9. Plays a role in controlling the development of connections of hypothalamic neurons to pituitary elements, allowing central neurons to reach the peripheral blood circulation and to deliver hormones for control of peripheral functions.

Miscellaneous

Marker of antero-posterior subdivisions of the somite.

Features

Showing features for dna binding.

153050100150200250300350400450500
TypeIDPosition(s)Description
DNA binding109-168Homeobox

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Functionsequence-specific double-stranded DNA binding
Biological Processcartilage condensation
Biological Processcommon myeloid progenitor cell proliferation
Biological Processdorsal spinal cord development
Biological Processolfactory bulb interneuron differentiation
Biological Processpattern specification process
Biological Processregulation of cell differentiation
Biological Processregulation of gene expression

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Homeobox protein unc-4 homolog
  • Alternative names
    • Homeobox protein Uncx4.1

Gene names

    • Name
      Uncx
    • Synonyms
      Uncx4.1

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    O08934
  • Secondary accessions
    • P70457
    • Q78DU3

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

Mice die perinatally and exhibit severe malformations of the axial skeleton. Pedicles of the neural arches and proximal ribs are not formed. In addition, dorsal root ganglia are disorganized. In the hypothalamo-neurohypophysial system, neurons are viable and able to express neuropeptides; however, the connectivity of magnocellular neurons with posterior pituitary elements is compromised.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 12 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003346251-530Homeobox protein unc-4 homolog

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in the paraxial mesoderm, in the developing kidney and central nervous system. In the somite, it is restricted to the caudal half of the newly formed somite and sclerotome. In the central nervous system, it is detected in the developing spinal cord, hindbrain, mesencephalon and telencephalon. Expressed in adult and embryonic magnocellular neurons of the hypothalamo-neurohypophysial system.

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region90-111Disordered
Compositional bias95-110Basic and acidic residues
Region165-360Disordered
Compositional bias192-207Basic and acidic residues
Compositional bias223-243Polar residues
Region400-530Disordered
Compositional bias405-423Pro residues
Compositional bias480-503Pro residues

Sequence similarities

Belongs to the paired homeobox family. Unc-4 subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    530
  • Mass (Da)
    53,936
  • Last updated
    1998-11-01 v2
  • Checksum
    2E3A4DE98428E381
MMDGRLLEHPHAQFGGSLGGVVGFPYPLGHHHVYELAGHQLQSAAAAAAAASVPFSIDGLLSGSCAAAAASVVNPTPLLPAACGVAGESQPFKLADSGDPDKESPGCKRRRTRTNFTGWQLEELEKAFNESHYPDVFMREALALRLDLVESRVQVWFQNRRAKWRKKENTKKGPGRPAHNSHPTTCSGEPMDPEEIARKELEKMEKKKRKHEKKLLKSQSRHLHSPGGLSLHSAPSSDSDSGGGGLSPEPPEPPPPTAAAKGPGAHGSGIAGSAPVPPGEPPAPGTCDPAFYPSQRSGAGSQPRLGRPADKDTVPCGPGAAATAGLPKASPFSVESLLSDSPPRRKATPANAAATAGLDFTPGLPCAPRTLIGKGHFLLYPITQPLGFLVPQAALKGGAGPELVPKDAPPAPPAPPAPPAQASFGTFPGPGGAADPAFARRSPEVVASPGPPAPASFRDLTAAAAESGAGDCADVGTVCPAASPPPPLETSPGPGPRAPSPPGEPATCGAAEPGAATGPSPPEGEEVDMD

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
V9GXC0V9GXC0_MOUSEUncx201

Features

Showing features for compositional bias, sequence conflict.

TypeIDPosition(s)Description
Compositional bias95-110Basic and acidic residues
Compositional bias192-207Basic and acidic residues
Compositional bias223-243Polar residues
Sequence conflict260in Ref. 5; AAC52830
Compositional bias405-423Pro residues
Compositional bias480-503Pro residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ001116
EMBL· GenBank· DDBJ
CAA04542.1
EMBL· GenBank· DDBJ
mRNA
AF247550
EMBL· GenBank· DDBJ
AAF71322.1
EMBL· GenBank· DDBJ
mRNA
BC051973
EMBL· GenBank· DDBJ
AAH51973.1
EMBL· GenBank· DDBJ
mRNA
Z96107
EMBL· GenBank· DDBJ
CAB09537.1
EMBL· GenBank· DDBJ
mRNA
AH006754
EMBL· GenBank· DDBJ
AAC52830.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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