O08934 · UNC4_MOUSE
- ProteinHomeobox protein unc-4 homolog
- GeneUncx
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids530 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Transcription factor involved in somitogenesis and neurogenesis. Required for the maintenance and differentiation of particular elements of the axial skeleton. May act upstream of PAX9. Plays a role in controlling the development of connections of hypothalamic neurons to pituitary elements, allowing central neurons to reach the peripheral blood circulation and to deliver hormones for control of peripheral functions.
Miscellaneous
Marker of antero-posterior subdivisions of the somite.
Features
Showing features for dna binding.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
DNA binding | 109-168 | Homeobox | ||||
Sequence: RRRTRTNFTGWQLEELEKAFNESHYPDVFMREALALRLDLVESRVQVWFQNRRAKWRKKE |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | DNA-binding transcription factor activity, RNA polymerase II-specific | |
Molecular Function | sequence-specific double-stranded DNA binding | |
Biological Process | cartilage condensation | |
Biological Process | common myeloid progenitor cell proliferation | |
Biological Process | dorsal spinal cord development | |
Biological Process | olfactory bulb interneuron differentiation | |
Biological Process | pattern specification process | |
Biological Process | regulation of cell differentiation | |
Biological Process | regulation of gene expression |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameHomeobox protein unc-4 homolog
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionO08934
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
Mice die perinatally and exhibit severe malformations of the axial skeleton. Pedicles of the neural arches and proximal ribs are not formed. In addition, dorsal root ganglia are disorganized. In the hypothalamo-neurohypophysial system, neurons are viable and able to express neuropeptides; however, the connectivity of magnocellular neurons with posterior pituitary elements is compromised.
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 12 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000334625 | 1-530 | Homeobox protein unc-4 homolog | |||
Sequence: MMDGRLLEHPHAQFGGSLGGVVGFPYPLGHHHVYELAGHQLQSAAAAAAAASVPFSIDGLLSGSCAAAAASVVNPTPLLPAACGVAGESQPFKLADSGDPDKESPGCKRRRTRTNFTGWQLEELEKAFNESHYPDVFMREALALRLDLVESRVQVWFQNRRAKWRKKENTKKGPGRPAHNSHPTTCSGEPMDPEEIARKELEKMEKKKRKHEKKLLKSQSRHLHSPGGLSLHSAPSSDSDSGGGGLSPEPPEPPPPTAAAKGPGAHGSGIAGSAPVPPGEPPAPGTCDPAFYPSQRSGAGSQPRLGRPADKDTVPCGPGAAATAGLPKASPFSVESLLSDSPPRRKATPANAAATAGLDFTPGLPCAPRTLIGKGHFLLYPITQPLGFLVPQAALKGGAGPELVPKDAPPAPPAPPAPPAQASFGTFPGPGGAADPAFARRSPEVVASPGPPAPASFRDLTAAAAESGAGDCADVGTVCPAASPPPPLETSPGPGPRAPSPPGEPATCGAAEPGAATGPSPPEGEEVDMD |
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in the paraxial mesoderm, in the developing kidney and central nervous system. In the somite, it is restricted to the caudal half of the newly formed somite and sclerotome. In the central nervous system, it is detected in the developing spinal cord, hindbrain, mesencephalon and telencephalon. Expressed in adult and embryonic magnocellular neurons of the hypothalamo-neurohypophysial system.
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 90-111 | Disordered | ||||
Sequence: QPFKLADSGDPDKESPGCKRRR | ||||||
Compositional bias | 95-110 | Basic and acidic residues | ||||
Sequence: ADSGDPDKESPGCKRR | ||||||
Region | 165-360 | Disordered | ||||
Sequence: RKKENTKKGPGRPAHNSHPTTCSGEPMDPEEIARKELEKMEKKKRKHEKKLLKSQSRHLHSPGGLSLHSAPSSDSDSGGGGLSPEPPEPPPPTAAAKGPGAHGSGIAGSAPVPPGEPPAPGTCDPAFYPSQRSGAGSQPRLGRPADKDTVPCGPGAAATAGLPKASPFSVESLLSDSPPRRKATPANAAATAGLDF | ||||||
Compositional bias | 192-207 | Basic and acidic residues | ||||
Sequence: DPEEIARKELEKMEKK | ||||||
Compositional bias | 223-243 | Polar residues | ||||
Sequence: LHSPGGLSLHSAPSSDSDSGG | ||||||
Region | 400-530 | Disordered | ||||
Sequence: GPELVPKDAPPAPPAPPAPPAQASFGTFPGPGGAADPAFARRSPEVVASPGPPAPASFRDLTAAAAESGAGDCADVGTVCPAASPPPPLETSPGPGPRAPSPPGEPATCGAAEPGAATGPSPPEGEEVDMD | ||||||
Compositional bias | 405-423 | Pro residues | ||||
Sequence: PKDAPPAPPAPPAPPAQAS | ||||||
Compositional bias | 480-503 | Pro residues | ||||
Sequence: PAASPPPPLETSPGPGPRAPSPPG |
Sequence similarities
Belongs to the paired homeobox family. Unc-4 subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length530
- Mass (Da)53,936
- Last updated1998-11-01 v2
- Checksum2E3A4DE98428E381
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
V9GXC0 | V9GXC0_MOUSE | Uncx | 201 |
Features
Showing features for compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 95-110 | Basic and acidic residues | ||||
Sequence: ADSGDPDKESPGCKRR | ||||||
Compositional bias | 192-207 | Basic and acidic residues | ||||
Sequence: DPEEIARKELEKMEKK | ||||||
Compositional bias | 223-243 | Polar residues | ||||
Sequence: LHSPGGLSLHSAPSSDSDSGG | ||||||
Sequence conflict | 260 | in Ref. 5; AAC52830 | ||||
Sequence: A → D | ||||||
Compositional bias | 405-423 | Pro residues | ||||
Sequence: PKDAPPAPPAPPAPPAQAS | ||||||
Compositional bias | 480-503 | Pro residues | ||||
Sequence: PAASPPPPLETSPGPGPRAPSPPG |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJ001116 EMBL· GenBank· DDBJ | CAA04542.1 EMBL· GenBank· DDBJ | mRNA | ||
AF247550 EMBL· GenBank· DDBJ | AAF71322.1 EMBL· GenBank· DDBJ | mRNA | ||
BC051973 EMBL· GenBank· DDBJ | AAH51973.1 EMBL· GenBank· DDBJ | mRNA | ||
Z96107 EMBL· GenBank· DDBJ | CAB09537.1 EMBL· GenBank· DDBJ | mRNA | ||
AH006754 EMBL· GenBank· DDBJ | AAC52830.1 EMBL· GenBank· DDBJ | Genomic DNA |