O08755 · HNF6_MOUSE

  • Protein
    Hepatocyte nuclear factor 6
  • Gene
    Onecut1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription. Stimulates the expression of Onecut3 in the developing endoderm.

Features

Showing features for dna binding.

146550100150200250300350400450
TypeIDPosition(s)Description
DNA binding283-369CUT
DNA binding385-444Homeobox

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleoplasm
Cellular Componentnucleus
Molecular Functionchromatin binding
Molecular FunctionDNA binding
Molecular FunctionDNA-binding transcription activator activity, RNA polymerase II-specific
Molecular FunctionDNA-binding transcription factor activity
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Processanatomical structure morphogenesis
Biological ProcessB cell differentiation
Biological Processcell fate commitment
Biological Processcell migration
Biological Processcilium assembly
Biological Processendocrine pancreas development
Biological Processendoderm development
Biological Processenteroendocrine cell differentiation
Biological Processepithelial cell development
Biological Processglucose metabolic process
Biological Processliver development
Biological Processnegative regulation of transforming growth factor beta receptor signaling pathway
Biological ProcessNotch signaling pathway
Biological Processpancreas development
Biological Processpancreatic A cell differentiation
Biological Processpancreatic D cell differentiation
Biological Processpositive regulation of cell migration
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processregulation of cell-matrix adhesion
Biological Processregulation of transcription by RNA polymerase II
Biological Processspleen development
Biological Processtransforming growth factor beta receptor signaling pathway
Biological Processtype B pancreatic cell differentiation

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Hepatocyte nuclear factor 6
  • Short names
    HNF-6
  • Alternative names
    • One cut domain family member 1
    • One cut homeobox 1

Gene names

    • Name
      Onecut1
    • Synonyms
      Hnf6, Hnf6a

Organism names

  • Taxonomic identifier
  • Strain
    • FVB/N
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    O08755

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Variants

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The viewer provides 9 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Chemistry

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002024031-465Hepatocyte nuclear factor 6

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Binds DNA as a monomer.

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region15-84Disordered
Region119-141Disordered
Compositional bias122-140Basic residues
Region443-465Disordered
Compositional bias446-465Polar residues

Sequence similarities

Belongs to the CUT homeobox family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    465
  • Mass (Da)
    50,952
  • Last updated
    1997-07-01 v1
  • Checksum
    A770D27DD5AAC896
MNAQLTMEAIGELHGVSHEPVPAPADLLGGSPHARSSVGHRGSHLPPAHPRSMGMASLLDGGSGGSDYHHHHRAPEHSLAGPLHPTMTMACETPPGMSMPTTYTTLTPLQPLPPISTVSDKFPHHHHHHHHHHHPHHHQRLAGNVSGSFTLMRDERGLASMNNLYTPYHKDVAGMGQSLSPLSGSGLGSIHNSQQGLPHYAHPGAAMPTDKMLTPNGFEAHHPAMLGRHGEQHLTPTSAGMVPINGLPPHHPHAHLNAQGHGQLLGTAREPNPSVTGAQVSNGSNSGQMEEINTKEVAQRITTELKRYSIPQAIFAQRVLCRSQGTLSDLLRNPKPWSKLKSGRETFRRMWKWLQEPEFQRMSALRLAACKRKEQEHGKDRGNTPKKPRLVFTDVQRRTLHAIFKENKRPSKELQITISQQLGLELSTVSNFFMNARRRSLDKWQDEGGSNSGSSSSSSSTCTKA

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias122-140Basic residues
Compositional bias446-465Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U95945
EMBL· GenBank· DDBJ
AAB53863.1
EMBL· GenBank· DDBJ
mRNA
BC024053
EMBL· GenBank· DDBJ
AAH24053.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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