O08739 · AMPD3_MOUSE
- ProteinAMP deaminase 3
- GeneAmpd3
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids766 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
AMP deaminase plays a critical role in energy metabolism.
Catalytic activity
- AMP + H+ + H2O = IMP + NH4+This reaction proceeds in the forward direction.
Cofactor
Note: Binds 1 zinc ion per subunit.
Pathway
Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 316 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: H | ||||||
Binding site | 318 | substrate | ||||
Sequence: H | ||||||
Binding site | 318 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: H | ||||||
Binding site | 387-392 | substrate | ||||
Sequence: KFNSKY | ||||||
Binding site | 585 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: H | ||||||
Binding site | 588 | substrate | ||||
Sequence: E | ||||||
Active site | 607 | Proton acceptor | ||||
Sequence: H | ||||||
Binding site | 662 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: D | ||||||
Binding site | 663-666 | substrate | ||||
Sequence: DPMQ |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | AMP deaminase activity | |
Molecular Function | metal ion binding | |
Biological Process | ADP catabolic process | |
Biological Process | ADP metabolic process | |
Biological Process | AMP catabolic process | |
Biological Process | AMP metabolic process | |
Biological Process | ATP metabolic process | |
Biological Process | energy homeostasis | |
Biological Process | erythrocyte homeostasis | |
Biological Process | GTP metabolic process | |
Biological Process | IMP biosynthetic process | |
Biological Process | IMP salvage |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAMP deaminase 3
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionO08739
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000194411 | 1-766 | AMP deaminase 3 | |||
Sequence: MPRQFPKLNMSDLDEHVRLLAEKVFAKVLREEDSKDVMSLFTVPEDCPIGQKEAKERELQKELAEQKSVETAKRKKSFKMIRSQSLSLQMPTQQDWKGPPTASPAMSPATPLVPGATSKPGPAPYAMPEYQRVTISGDYCAGITVEDYEQAAKSLAKALMIREKYARLAYHRFPRTTAQYLAHQGESVPLEEGLPDFHPPPLPQEDPYCLDDAPPNLGYLVRMHGGVLFVYDNQTMLERQEPHSLPYPDLETYIVDMSHILALITDGPTKTYCHRRLNFLESKFSLHEMLNEMSEFKELKSNPHRDFYNVRKVDTHIHAAACMNQKHLLRFIKHTYQTEPDRTVAEKLGRKITLRQVFDSLHMDPYDLTVDSLDVHAGRQTFHRFDKFNSKYNPVGASELRDLYLKTENYLGGEYFARMVKEVARELEDSKYQYSEPRLSIYGRSPKEWSSLARWFIQHKVYSPNMRWIIQVPRIYDIFRSKKLLPNFGKMLENIFLPLFKATINPQDHRELHLFLKYVTGFDSVDDESKHSDHMFSDKSPSPDLWTSEQNPPYSYYLYYMYANIMVLNNLRRERGLSTFLFRPHCGEAGSITHLVSAFLTADNISHGLLLKKSPVLQYLYYLAQIPIAMSPLSNNSLFLEYSKNPLREFLHKGLHVSLSTDDPMQFHYTKEALMEEYAIAAQVWKLSTCDLCEIARNSVLQSGLSHQEKQKFLGQNYYKEGPEGNDIRKTNVAQIRMAFRYETLCNELSFLSDAMKSEEITALTK | ||||||
Modified residue | 85 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 107 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Found in heart, lung brain, spleen, kidney and to a lesser extent in liver.
Gene expression databases
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 89-119 | Disordered | ||||
Sequence: QMPTQQDWKGPPTASPAMSPATPLVPGATSK |
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length766
- Mass (Da)88,652
- Last updated2011-07-27 v2
- Checksum94991133B18B8AA5
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
F6XQD0 | F6XQD0_MOUSE | Ampd3 | 137 | ||
D3YU73 | D3YU73_MOUSE | Ampd3 | 111 | ||
D3Z4N3 | D3Z4N3_MOUSE | Ampd3 | 184 | ||
A0A1L1SRX2 | A0A1L1SRX2_MOUSE | Ampd3 | 775 |
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 251 | in Ref. 1; BAA19933 | ||||
Sequence: E → K | ||||||
Sequence conflict | 645 | in Ref. 1; BAA19933 | ||||
Sequence: N → K |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
D85596 EMBL· GenBank· DDBJ | BAA19933.1 EMBL· GenBank· DDBJ | mRNA | ||
D88994 EMBL· GenBank· DDBJ | BAA32548.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
AK133465 EMBL· GenBank· DDBJ | BAE21671.1 EMBL· GenBank· DDBJ | mRNA | ||
CH466531 EMBL· GenBank· DDBJ | EDL16988.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH466531 EMBL· GenBank· DDBJ | EDL16989.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH466531 EMBL· GenBank· DDBJ | EDL16990.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC040366 EMBL· GenBank· DDBJ | AAH40366.1 EMBL· GenBank· DDBJ | mRNA | ||
BC056380 EMBL· GenBank· DDBJ | AAH56380.1 EMBL· GenBank· DDBJ | mRNA |