O08569 · ZP3R_CAVPO
- ProteinZona pellucida sperm-binding protein 3 receptor
- GeneZP3R
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids533 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Probably involved in the formation of the dense core and M1 domain of the acrosome. May also regulate the release of certain secretory proteins following the acrosomal reaction.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | acrosomal lumen | |
Cellular Component | acrosomal matrix | |
Cellular Component | extracellular space | |
Cellular Component | plasma membrane | |
Molecular Function | structural molecule activity | |
Biological Process | acrosome reaction | |
Biological Process | negative regulation of complement activation, classical pathway | |
Biological Process | organelle organization | |
Biological Process | T cell mediated immunity |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameZona pellucida sperm-binding protein 3 receptor
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Hystricomorpha > Caviidae > Cavia
Accessions
- Primary accessionO08569
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Sperm acrosomal matrix. Restricted to the M1 domain of the apical segment of the acrosome.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond, glycosylation.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-28 | ||||
Chain | PRO_0000006012 | 29-533 | Zona pellucida sperm-binding protein 3 receptor | ||
Disulfide bond | 30↔74 | ||||
Disulfide bond | 60↔86 | ||||
Glycosylation | 68 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 77 | N-linked (GlcNAc...) asparagine | |||
Disulfide bond | 91↔132 | ||||
Disulfide bond | 118↔148 | ||||
Disulfide bond | 153↔196 | ||||
Disulfide bond | 182↔213 | ||||
Glycosylation | 185 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 191 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 200 | N-linked (GlcNAc...) asparagine | |||
Disulfide bond | 218↔260 | ||||
Disulfide bond | 246↔273 | ||||
Disulfide bond | 278↔328 | ||||
Disulfide bond | 312↔340 | ||||
Disulfide bond | 345↔393 | ||||
Disulfide bond | 378↔406 | ||||
Disulfide bond | 411↔452 | ||||
Glycosylation | 433 | N-linked (GlcNAc...) asparagine | |||
Disulfide bond | 438↔465 | ||||
Glycosylation | 455 | N-linked (GlcNAc...) asparagine | |||
Post-translational modification
The N-terminus may be blocked.
Keywords
- PTM
PTM databases
Expression
Tissue specificity
Testis. Not expressed in heart, brain, liver or kidney.
Gene expression databases
Interaction
Subunit
Homooligomer; disulfide-linked. May contain 6-8 monomers per oligomer.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 29-88 | Sushi 1 | |||
Domain | 89-150 | Sushi 2 | |||
Domain | 151-215 | Sushi 3 | |||
Domain | 216-275 | Sushi 4 | |||
Domain | 276-342 | Sushi 5 | |||
Domain | 343-408 | Sushi 6 | |||
Domain | 409-467 | Sushi 7 | |||
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length533
- Mass (Da)59,773
- Last updated1997-07-01 v1
- ChecksumEDBDDED487A45389
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U75654 EMBL· GenBank· DDBJ | AAC13888.1 EMBL· GenBank· DDBJ | mRNA |