O08569 · ZP3R_CAVPO

  • Protein
    Zona pellucida sperm-binding protein 3 receptor
  • Gene
    ZP3R
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Probably involved in the formation of the dense core and M1 domain of the acrosome. May also regulate the release of certain secretory proteins following the acrosomal reaction.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentacrosomal lumen
Cellular Componentacrosomal matrix
Cellular Componentextracellular space
Cellular Componentplasma membrane
Molecular Functionstructural molecule activity
Biological Processacrosome reaction
Biological Processnegative regulation of complement activation, classical pathway
Biological Processorganelle organization
Biological ProcessT cell mediated immunity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Zona pellucida sperm-binding protein 3 receptor
  • Alternative names
    • Acrosomal matrix component 67 (Protein AM67; p67)

Gene names

    • Name
      ZP3R

Organism names

  • Taxonomic identifier
  • Strain
    • Hartley
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Hystricomorpha > Caviidae > Cavia

Accessions

  • Primary accession
    O08569

Proteomes

Organism-specific databases

Subcellular Location

Note: Sperm acrosomal matrix. Restricted to the M1 domain of the apical segment of the acrosome.

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation.

Type
IDPosition(s)Description
Signal1-28
ChainPRO_000000601229-533Zona pellucida sperm-binding protein 3 receptor
Disulfide bond30↔74
Disulfide bond60↔86
Glycosylation68N-linked (GlcNAc...) asparagine
Glycosylation77N-linked (GlcNAc...) asparagine
Disulfide bond91↔132
Disulfide bond118↔148
Disulfide bond153↔196
Disulfide bond182↔213
Glycosylation185N-linked (GlcNAc...) asparagine
Glycosylation191N-linked (GlcNAc...) asparagine
Glycosylation200N-linked (GlcNAc...) asparagine
Disulfide bond218↔260
Disulfide bond246↔273
Disulfide bond278↔328
Disulfide bond312↔340
Disulfide bond345↔393
Disulfide bond378↔406
Disulfide bond411↔452
Glycosylation433N-linked (GlcNAc...) asparagine
Disulfide bond438↔465
Glycosylation455N-linked (GlcNAc...) asparagine

Post-translational modification

The N-terminus may be blocked.

Keywords

PTM databases

Expression

Tissue specificity

Testis. Not expressed in heart, brain, liver or kidney.

Gene expression databases

Interaction

Subunit

Homooligomer; disulfide-linked. May contain 6-8 monomers per oligomer.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain29-88Sushi 1
Domain89-150Sushi 2
Domain151-215Sushi 3
Domain216-275Sushi 4
Domain276-342Sushi 5
Domain343-408Sushi 6
Domain409-467Sushi 7

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    533
  • Mass (Da)
    59,773
  • Last updated
    1997-07-01 v1
  • Checksum
    EDBDDED487A45389
MFPRLQAVSAPALLQITLMAVLLAPVLGDCGPPPILPFASPVIQSYETNFRTGTALKYNCHRGYWRVNSSHVICDINGSWIYNVFCAKKRCRNPGELANGKVEIITDLLFGSTIEFSCSKGYSLIGSTTSQCESQGKTVDWSDPLPECVIVKCDSPPDISNGKHSGTDEDLYTYGSLVTYVCDPNYSLLGNASISCLVANKTVGVWSSNPPTCEKVICRQPHIPKGIFLSGFGFYYTYKDTLVISCKKGYILRGSSIIHCEANSKWYPSIPTCEPNGCIDLPEVPYISWERNVLSLKNQEIFEIGSLLKYDCKTGYRPTPNEPRTVTCQENLKWAISKGCERVCCPTPNMEKMRIINERRDFTGVCVYAYEDYIFYMCDEGYYPISADGRSSCQADGMWNPKMPACESAVCLKPDILNGKLSVEKDHYTETENVTIHCDSGYEVVGPQNIICSENRTWTPEIPKCEWEVPEECKQVAAGRKLLECLPNPSDVKMALEVYKLSLEIEQLEKEKYVKIQEKFSKKEMKQLTSALH

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U75654
EMBL· GenBank· DDBJ
AAC13888.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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