the role of KMT2A and KMT2B two histone H3 lysine 4 methylases with cardinal roles in development through individual and combined inactivation were investigated.
The results reveal a critical role for Mll2 in proliferation and cardiac lineage differentiation of mouse ESCs and provide novel molecular insight into the mechanisms of cardiac development and disease.
Identify Mll2 (KMT2b) as the enzyme catalyzing H3K4 trimethylation at bivalently marked promoters in embryonic stem cells. Mll2 is required for H3K4 trimethylation at Homeobox gene clusters.
study found in macrophages Wbp7 was required for expression of Pigp an essential component of the GPI-GlcNAc transferase the enzyme catalyzing the first step of glycosylphosphatidylinositol (GPI) anchor synthesis; data link a histone-modifying enzyme to a biosynthetic pathway and indicate a specialized biological role for Wbp7 in macrophage function
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