O08405 · KATG2_MYCFO
- ProteinCatalase-peroxidase 2
- GenekatG2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids733 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. May play a role in the intracellular survival of mycobacteria (By similarity).
Catalytic activity
- AH2 + H2O2 = A + 2 H2O
Cofactor
Note: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.
Features
Showing features for site, active site, binding site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | catalase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | hydrogen peroxide catabolic process | |
Biological Process | response to oxidative stress |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameCatalase-peroxidase 2
- EC number
- Short namesCP 2
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Mycobacteriaceae > Mycolicibacterium
Accessions
- Primary accessionO08405
PTM/Processing
Features
Showing features for chain, cross-link.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000345093 | 1-733 | Catalase-peroxidase 2 | |||
Sequence: MAEAETHPPIGESQTEPAESGCPMRIKPPVEGGSNRDWWPNAVNLKILQKNPPAIDPSDEGYDSEAVKSLDVEAFQRDFDELLTNSQDWWPADFGHYGPLFVRMSWHAAGTYRVEDGRGGGGRGMQPFAPLNSWPDNVSLDKARRLLWPLKKKYGKQISWSDLIVYSGNRAMEHMGFKTAGFAFGRPDYWEPEEDIYWGAEAEWLGSQDRYAGANGDRTKLENPPXXPHMGLIYVNPEGPEGNPDYLAAAIDIRETFGRMAMNDIETAALIVGGHTFGKTHGATDIENGVEPEXXPLEQMGLGWANPGLGNDTVSSGLEVTWTQHPTKWDNSFLEILYSNEWELTKSPAGANQWKPKDNGWANSWPMAQGTGKTHPSMLTTDLSMRFDPIYGEITRRWLDHPEELAEEYAKAWFKLIHRDMGPVTRYLGPLVPKQTWLWQDIIPAGKQLSDADVATLKAAIADSGLSIQQLVNTAWKAAASYRSSDMRGGNGGRIRLQPQLGWEVNEPEELAPVIAKLEEIQAASDSGVSFADLVVLGGVVGLEKAIKAAGFDVAVPFTSGPRDALQEQTDVDSFAYLEPKGDGFRNFVAKGDSVPAEYRLIDRANLLGLSAPQMTVLIGGLRVLGANHGGSELGVLTDKVGQLTNDYFVNLTDMGTKWAPAPADDGTYVGTDRATGSPKWTASRVDLLFGSNSQLRALAEVYAEDDSKEKFVKDFVAAWTKVMNADRFDLEA | ||||||
Cross-link | 106↔234 | Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-260) | ||||
Sequence: WHAAGTYRVEDGRGGGGRGMQPFAPLNSWPDNVSLDKARRLLWPLKKKYGKQISWSDLIVYSGNRAMEHMGFKTAGFAFGRPDYWEPEEDIYWGAEAEWLGSQDRYAGANGDRTKLENPPXXPHMGLIY | ||||||
Cross-link | 234↔260 | Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-106) | ||||
Sequence: YVNPEGPEGNPDYLAAAIDIRETFGRM |
Post-translational modification
Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.
Interaction
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-35 | Disordered | ||||
Sequence: MAEAETHPPIGESQTEPAESGCPMRIKPPVEGGSN | ||||||
Region | 282-308 | Disordered | ||||
Sequence: GATDIENGVEPEXXPLEQMGLGWANPG | ||||||
Region | 349-375 | Disordered | ||||
Sequence: AGANQWKPKDNGWANSWPMAQGTGKTH |
Sequence similarities
Belongs to the peroxidase family. Peroxidase/catalase subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length733
- Mass (Da)80,596
- Last updated1997-07-01 v1
- Checksum20C8BCB076F9E58F