O08405 · KATG2_MYCFO

Function

function

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. May play a role in the intracellular survival of mycobacteria (By similarity).

Catalytic activity

Cofactor

heme b (UniProtKB | Rhea| CHEBI:60344 )

Note: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.

Features

Showing features for site, active site, binding site.

TypeIDPosition(s)Description
Site103Transition state stabilizer
Active site107Proton acceptor
Binding site275Fe (UniProtKB | ChEBI) of heme (UniProtKB | ChEBI); axial binding residue

GO annotations

AspectTerm
Molecular Functioncatalase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processhydrogen peroxide catabolic process
Biological Processresponse to oxidative stress

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Catalase-peroxidase 2
  • EC number
  • Short names
    CP 2
  • Alternative names
    • Peroxidase/catalase 2

Gene names

    • Name
      katG2
    • Synonyms
      katGII

Organism names

Accessions

  • Primary accession
    O08405

PTM/Processing

Features

Showing features for chain, cross-link.

TypeIDPosition(s)Description
ChainPRO_00003450931-733Catalase-peroxidase 2
Cross-link106↔234Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-260)
Cross-link234↔260Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-106)

Post-translational modification

Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.

Interaction

Subunit

Homodimer or homotetramer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-35Disordered
Region282-308Disordered
Region349-375Disordered

Sequence similarities

Belongs to the peroxidase family. Peroxidase/catalase subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    733
  • Mass (Da)
    80,596
  • Last updated
    1997-07-01 v1
  • Checksum
    20C8BCB076F9E58F
MAEAETHPPIGESQTEPAESGCPMRIKPPVEGGSNRDWWPNAVNLKILQKNPPAIDPSDEGYDSEAVKSLDVEAFQRDFDELLTNSQDWWPADFGHYGPLFVRMSWHAAGTYRVEDGRGGGGRGMQPFAPLNSWPDNVSLDKARRLLWPLKKKYGKQISWSDLIVYSGNRAMEHMGFKTAGFAFGRPDYWEPEEDIYWGAEAEWLGSQDRYAGANGDRTKLENPPXXPHMGLIYVNPEGPEGNPDYLAAAIDIRETFGRMAMNDIETAALIVGGHTFGKTHGATDIENGVEPEXXPLEQMGLGWANPGLGNDTVSSGLEVTWTQHPTKWDNSFLEILYSNEWELTKSPAGANQWKPKDNGWANSWPMAQGTGKTHPSMLTTDLSMRFDPIYGEITRRWLDHPEELAEEYAKAWFKLIHRDMGPVTRYLGPLVPKQTWLWQDIIPAGKQLSDADVATLKAAIADSGLSIQQLVNTAWKAAASYRSSDMRGGNGGRIRLQPQLGWEVNEPEELAPVIAKLEEIQAASDSGVSFADLVVLGGVVGLEKAIKAAGFDVAVPFTSGPRDALQEQTDVDSFAYLEPKGDGFRNFVAKGDSVPAEYRLIDRANLLGLSAPQMTVLIGGLRVLGANHGGSELGVLTDKVGQLTNDYFVNLTDMGTKWAPAPADDGTYVGTDRATGSPKWTASRVDLLFGSNSQLRALAEVYAEDDSKEKFVKDFVAAWTKVMNADRFDLEA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
Y07866
EMBL· GenBank· DDBJ
CAA69193.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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