O06758 · FLHA_HELPY
- ProteinFlagellar biosynthesis protein FlhA
- GeneflhA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids733 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Involved in the export of flagellum proteins.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Biological Process | bacterial-type flagellum assembly | |
Biological Process | protein secretion |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameFlagellar biosynthesis protein FlhA
Gene names
Organism names
- Strains
- Taxonomic lineageBacteria > Campylobacterota > Epsilonproteobacteria > Campylobacterales > Helicobacteraceae > Helicobacter
Accessions
- Primary accessionO06758
- Secondary accessions
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 28-48 | Helical | ||||
Sequence: LVVFVIAILAIIIVPLPPFVL | ||||||
Transmembrane | 49-69 | Helical | ||||
Sequence: DFLLTISIALSVLIILIGLYI | ||||||
Transmembrane | 125-145 | Helical | ||||
Sequence: GNYVIGAIIFSILVLVNLLVV | ||||||
Transmembrane | 213-233 | Helical | ||||
Sequence: AIASIIITLINIIGGFLVGVF | ||||||
Transmembrane | 246-266 | Helical | ||||
Sequence: FTILTIGDGLVGQIPALIIAT | ||||||
Transmembrane | 291-311 | Helical | ||||
Sequence: LTNKSKTLVIVGAILLLFATI | ||||||
Transmembrane | 313-333 | Helical | ||||
Sequence: GLPTFSLAFVGTLFLFIAWLI |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000190018 | 1-733 | Flagellar biosynthesis protein FlhA | |||
Sequence: MANERSKLAFKKTFPVFKRFLQSKDLALVVFVIAILAIIIVPLPPFVLDFLLTISIALSVLIILIGLYIDKPTDFSAFPTLLLIVTLYRLALNVATTRMILTQGYKGPSAVSDIITAFGEFSVSGNYVIGAIIFSILVLVNLLVVTNGSTRVTEVRARFALDAMPGKQMAIDADLNSGLIDDKEAKKRRAALSQEADFYGAMDGASKFVKGDAIASIIITLINIIGGFLVGVFQRDMSLSFSASTFTILTIGDGLVGQIPALIIATATGIVATRTTQNEEEDFASKLITQLTNKSKTLVIVGAILLLFATIPGLPTFSLAFVGTLFLFIAWLISREGKDGLLTKLENYLSQKFGLDLSEKPHSSKIKPHTPTTRAKTQEELKREEEQAIDEVLKIEFLELALGYQLISLADMKQGGDLLERIRGIRKKIASDYGFLMPQIRIRDNLQLPPTHYEIKLKGIVIGEGMVMPDKFLAMNTGFVNKEIEGIPTKEPAFGMDALWIETKNKEEAIIQGYTIIDPSTVIATHTSELVKKYAEDFITKDEVKSLLERLAKDYPTIVEESKKIPTGAIRSVLQALLHEKIPIKDMLTILETITDIAPLVQNDVNILTEQVRARLSRVITNAFKSEDGRLKFLTFSTDSEQFLLNKLRENGTSKSLLLNVGELQKLIEVVSEEAMKVLQKGIAPVILIVEPNLRKALSNQMEQARIDVIVLSHAELDPNSNFEALGTIHINF |
Proteomic databases
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | O06758 | HP_1122 O25747 | 2 | EBI-6407872, EBI-527952 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 360-381 | Disordered | ||||
Sequence: KPHSSKIKPHTPTTRAKTQEEL |
Sequence similarities
Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length733
- Mass (Da)80,909
- Last updated1997-11-01 v2
- ChecksumC15B4C9EBB3333C5
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 113 | in Ref. 1; CAA73825 | ||||
Sequence: D → I | ||||||
Sequence conflict | 267 | in Ref. 1; CAA73825 | ||||
Sequence: A → R | ||||||
Sequence conflict | 305-307 | in Ref. 1 | ||||
Sequence: LLL → YC | ||||||
Sequence conflict | 309 | in Ref. 1 | ||||
Sequence: A → C | ||||||
Sequence conflict | 324 | in Ref. 1; CAA73825 | ||||
Sequence: T → A | ||||||
Sequence conflict | 370 | in Ref. 1 and 3 | ||||
Sequence: T → A | ||||||
Sequence conflict | 381 | in Ref. 1; CAA73825 | ||||
Sequence: L → I | ||||||
Sequence conflict | 407 | in Ref. 1; CAA73825 | ||||
Sequence: I → Y | ||||||
Sequence conflict | 670 | in Ref. 1; CAA73825 | ||||
Sequence: V → A | ||||||
Sequence conflict | 670 | in Ref. 3; CAA70007 | ||||
Sequence: V → G | ||||||
Sequence conflict | 710 | in Ref. 3; CAA70007 | ||||
Sequence: I → V |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE000511 EMBL· GenBank· DDBJ | AAD08087.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Y13395 EMBL· GenBank· DDBJ | CAA73825.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Y08762 EMBL· GenBank· DDBJ | CAA70007.1 EMBL· GenBank· DDBJ | Genomic DNA |