O05465 · AMPC_PSYIM
- ProteinBeta-lactamase
- GeneampC
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids401 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.
Miscellaneous
The class C beta-lactamase family has a specific amino-acid numbering system known as SANC, for structural alignment-based numbering of class C beta-lactamases, or else the simpler name structural position. A multiple sequence alignment was used to derive a consensus sequence and then the consensus was numbered taking into account insertions and deletions. This allows use of identical numbers, e.g. for active site residues, despite differences in protein length. UniProt always uses natural numbering of residues, hence there appear to be differences in numbering between this entry and some papers.
Catalytic activity
- a beta-lactam + H2O = a substituted beta-amino acid
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 102 | Acyl-ester intermediate | ||||
Sequence: S | ||||||
Active site | 188 | Proton acceptor | ||||
Sequence: Y | ||||||
Binding site | 353-355 | substrate | ||||
Sequence: KTG |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Cellular Component | outer membrane-bounded periplasmic space | |
Molecular Function | beta-lactamase activity | |
Biological Process | antibiotic catabolic process | |
Biological Process | response to antibiotic |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameBeta-lactamase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Moraxellales > Moraxellaceae > Psychrobacter
Accessions
- Primary accessionO05465
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-39 | |||||
Sequence: MKLFTSTLTAKKSSTHKPLISLALSVLISTLLISETAQA | ||||||
Chain | PRO_0000016964 | 40-401 | Beta-lactamase | |||
Sequence: ADANDRLEQEVDKQAKQLMAQYQIPGMAFGIIVDGKSHFYNYGLADKQRNQPVSEDTIFELGSVSKTFAATLASYSELNGTLSLDDTADKYIPYLKNSAIGNTKLISLVTYSAGGYHYRCLKTLENNKELLQYYKSWHPDFPVNSKRLYSNASIGLFGYISALSMHSDYTKLIENTVLPSLKMTNTFVDVPANKMEDYAFGYNAAGEPIRVNPGMLDAEAYGIKSTSADMTRFMAANMGLVTVDSQMQQALDNNRKGYYRTKSFTQGLAWEMYPLPTTLQQLVEGNSTETILQPQPIQLNEPPTPVLNDVWVNKTGATNGFGAYIAYMPAKKTGMFILANKNYPNTERVKAAYTILDSVMNN |
Structure
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length401
- Mass (Da)44,451
- Last updated1997-07-01 v1
- Checksum93F0DB278EA8E043
Keywords
- Technical term