O05465 · AMPC_PSYIM

Function

function

This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.

Miscellaneous

The class C beta-lactamase family has a specific amino-acid numbering system known as SANC, for structural alignment-based numbering of class C beta-lactamases, or else the simpler name structural position. A multiple sequence alignment was used to derive a consensus sequence and then the consensus was numbered taking into account insertions and deletions. This allows use of identical numbers, e.g. for active site residues, despite differences in protein length. UniProt always uses natural numbering of residues, hence there appear to be differences in numbering between this entry and some papers.

Catalytic activity

Features

Showing features for active site, binding site.

140150100150200250300350400
TypeIDPosition(s)Description
Active site102Acyl-ester intermediate
Active site188Proton acceptor
Binding site353-355substrate

GO annotations

AspectTerm
Cellular Componentextracellular region
Cellular Componentouter membrane-bounded periplasmic space
Molecular Functionbeta-lactamase activity
Biological Processantibiotic catabolic process
Biological Processresponse to antibiotic

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Beta-lactamase
  • EC number
  • Alternative names
    • Cephalosporinase

Gene names

    • Name
      ampC
    • Synonyms
      bla

Organism names

  • Taxonomic identifier
  • Strain
    • A5
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Moraxellales > Moraxellaceae > Psychrobacter

Accessions

  • Primary accession
    O05465

Subcellular Location

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-39
ChainPRO_000001696440-401Beta-lactamase

Structure

Family & Domains

Sequence similarities

Belongs to the class-C beta-lactamase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    401
  • Mass (Da)
    44,451
  • Last updated
    1997-07-01 v1
  • Checksum
    93F0DB278EA8E043
MKLFTSTLTAKKSSTHKPLISLALSVLISTLLISETAQAADANDRLEQEVDKQAKQLMAQYQIPGMAFGIIVDGKSHFYNYGLADKQRNQPVSEDTIFELGSVSKTFAATLASYSELNGTLSLDDTADKYIPYLKNSAIGNTKLISLVTYSAGGYHYRCLKTLENNKELLQYYKSWHPDFPVNSKRLYSNASIGLFGYISALSMHSDYTKLIENTVLPSLKMTNTFVDVPANKMEDYAFGYNAAGEPIRVNPGMLDAEAYGIKSTSADMTRFMAANMGLVTVDSQMQQALDNNRKGYYRTKSFTQGLAWEMYPLPTTLQQLVEGNSTETILQPQPIQLNEPPTPVLNDVWVNKTGATNGFGAYIAYMPAKKTGMFILANKNYPNTERVKAAYTILDSVMNN

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X83586
EMBL· GenBank· DDBJ
CAA58569.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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