O04714 · GCR1_ARATH

Function

function

Together with GPA1, may regulate the cell cycle via a signaling cascade that uses phosphatidylinositol-specific phospholipase C (PI-PLC) as an effector and inositol 1,4,5-trisphosphate(IP3) as a second messenger. Promotes PI-PLC activity and IP3 accumulation. Involved in the blue light (BL) signaling. Together with GPA1 and ADT3, required for BL-mediated synthesis of phenylpyruvate and subsequently of phenylalanine (Phe), in etiolated seedlings. Probably involved in cytokinin signal transduction. Plays a positive role in gibberellin- (GA) and brassinosteroid- (BR) regulated seed germination, probably independently of a heterotrimeric G-protein. Mediates seed dormancy abolition, and promotes seed germination and flowering.

Caution

An article reported a role as negative regulator of ABA during seed germination; however, this paper was later retracted.

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentGolgi apparatus
Cellular Componentplant-type vacuole
Cellular Componentplasma membrane
Molecular FunctionG protein-coupled receptor activity
Biological Processabscisic acid-activated signaling pathway
Biological Processblue light signaling pathway
Biological Processbrassinosteroid mediated signaling pathway
Biological Processcell surface receptor signaling pathway
Biological Processcytokinin-activated signaling pathway
Biological Processflower development
Biological Processgibberellic acid mediated signaling pathway
Biological ProcessL-phenylalanine biosynthetic process
Biological Processlipid metabolic process
Biological Processmaintenance of seed dormancy
Biological Processmitotic cell cycle
Biological Processnegative regulation of abscisic acid-activated signaling pathway
Biological Processpositive regulation of gibberellic acid mediated signaling pathway
Biological Processregulation of inositol trisphosphate biosynthetic process
Biological Processresponse to cytokinin
Biological Processresponse to low fluence blue light stimulus by blue low-fluence system
Biological Processtyrosine biosynthetic process

Keywords

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    G-protein coupled receptor 1

Gene names

    • Name
      GCR1
    • ORF names
      F11A17.17
    • Ordered locus names
      At1g48270

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    O04714
  • Secondary accessions
    • O04214
    • Q8LPG0

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Note: Localized to the outer edge of the leaf epidermal cells in a punctuate pattern.

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain2-23Extracellular
Transmembrane24-44Helical; Name=1
Topological domain45-51Cytoplasmic
Transmembrane52-72Helical; Name=2
Topological domain73-84Extracellular
Transmembrane85-105Helical; Name=3
Topological domain106-120Cytoplasmic
Transmembrane121-141Helical; Name=4
Topological domain142-160Extracellular
Transmembrane161-181Helical; Name=5
Topological domain182-213Cytoplasmic
Transmembrane214-234Helical; Name=6
Topological domain235-246Extracellular
Transmembrane247-267Helical; Name=7
Topological domain268-326Cytoplasmic

Keywords

Phenotypes & Variants

Disruption phenotype

Improved drought tolerance accompanied by lower rates of water loss. Impaired sensitivity to gibberellin (GA) and brassinosteroid (BR) in seed germination. Hypersensitivity to ABA and glucose (Glc) during and after seed germination. Altered response to blue light (BL).

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 13 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for initiator methionine, modified residue, chain, disulfide bond, glycosylation.

TypeIDPosition(s)Description
Initiator methionine1Removed
Modified residue2N-acetylserine
ChainPRO_00004121912-326G-protein coupled receptor 1
Disulfide bond80↔151
Glycosylation143N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Mostly present in the meristematic regions. Expressed at low levels in seedlings, vascular tissues of cotyledons, hypocotyl, and roots, stems, leaves, flowering buds and siliques. In dark-grown seedlings, localized in the cotyledons and the hook.

Induction

Modulated during the cell cycle with a peak during the early G1 phase.

Developmental stage

In seedlings, mostly expressed in small roots, and to a lower extent in hypocotyls. In young plants, equaly expressed in leaves, roots, and shoot tip. In old plants, present in roots, flower buds and young siliques, but not in leaves.

Gene expression databases

Interaction

Subunit

Interacts with GPA1.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY O04714GPA1 P180646EBI-443899, EBI-443890

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Complete
  • Length
    326
  • Mass (Da)
    37,248
  • Last updated
    1997-07-01 v1
  • Checksum
    C00F1109720A4453
MSAVLTAGGGLTAGDRSIITAINTGASSLSFVGSAFIVLCYCLFKELRKFSFKLVFYLALSDMLCSFFLIVGDPSKGFICYAQGYTTHFFCVASFLWTTTIAFTLHRTVVKHKTDVEDLEAMFHLYVWGTSLVVTVIRSFGNNHSHLGPWCWTQTGLKGKAVHFLTFYAPLWGAILYNGFTYFQVIRMLRNARRMAVGMSDRVDQFDNRAELKVLNRWGYYPLILIGSWAFGTINRIHDFIEPGHKIFWLSVLDVGTAALMGLFNSIAYGFNSSVRRAIHERLELFLPERLYRWLPSNFRPKNHLILHQQQQQRSEMVSLKTEDQQ

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict63in Ref. 5; AAM20722/AAN15633
Sequence conflict96in Ref. 1; CAA72145

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
Y11278
EMBL· GenBank· DDBJ
CAA72145.1
EMBL· GenBank· DDBJ
mRNA
U95142
EMBL· GenBank· DDBJ
AAC49961.1
EMBL· GenBank· DDBJ
Genomic DNA
U95143
EMBL· GenBank· DDBJ
AAC49962.1
EMBL· GenBank· DDBJ
mRNA
AC007932
EMBL· GenBank· DDBJ
AAD49769.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002684
EMBL· GenBank· DDBJ
AEE32270.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002684
EMBL· GenBank· DDBJ
ANM59445.1
EMBL· GenBank· DDBJ
Genomic DNA
AY099871
EMBL· GenBank· DDBJ
AAM20722.1
EMBL· GenBank· DDBJ
mRNA
BT000314
EMBL· GenBank· DDBJ
AAN15633.1
EMBL· GenBank· DDBJ
mRNA
AK228479
EMBL· GenBank· DDBJ
BAF00405.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp