O04274 · LDOX_PERFR
- ProteinLeucoanthocyanidin dioxygenase
- GeneANS
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids362 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Oxidation of leucoanthocyanidins into anthocyanidins.
Catalytic activity
- a (2R,3S,4S)-leucoanthocyanidin + 2-oxoglutarate + O2 = a 4-H-anthocyanidin with a 3-hydroxy group + succinate + CO2 + 2 H2O
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 Fe cation per subunit.
Note: Binds 1 ascorbate molecule per subunit.
Pathway
Pigment biosynthesis; anthocyanin biosynthesis.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 238 | Fe cation (UniProtKB | ChEBI) | |||
Binding site | 240 | Fe cation (UniProtKB | ChEBI) | |||
Binding site | 294 | Fe cation (UniProtKB | ChEBI) | |||
Active site | 304 | ||||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | L-ascorbic acid binding | |
Molecular Function | leucocyanidin oxygenase activity | |
Molecular Function | metal ion binding | |
Biological Process | anthocyanin-containing compound biosynthetic process | |
Biological Process | coumarin biosynthetic process | |
Biological Process | response to molecule of fungal origin |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameLeucoanthocyanidin dioxygenase
- EC number
- Short namesLDOX; Leucocyanidin oxygenase
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > asterids > lamiids > Lamiales > Lamiaceae > Nepetoideae > Elsholtzieae > Perilla
Accessions
- Primary accessionO04274
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000067302 | 1-362 | Leucoanthocyanidin dioxygenase | ||
Expression
Tissue specificity
Expressed in red but not in green forma of P.frutescens. In red forma, it is predominantly expressed in stems and leaves, but not in roots.
Structure
Sequence
- Sequence statusComplete
- Length362
- Mass (Da)40,826
- Last updated1997-07-01 v1
- Checksum7A03B4E86F91E1EA
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB003779 EMBL· GenBank· DDBJ | BAA20143.1 EMBL· GenBank· DDBJ | mRNA |