O02482 · UNC37_CAEEL
- ProteinTranscription factor unc-37
- Geneunc-37
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids612 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Transcriptional corepressor that functions with the neural specificity gene unc-4 to govern motor neuron identity (PubMed:10557206, PubMed:17289921, PubMed:9165118).
In concert with unc-4, represses the expression of VB-specific genes such as ceh-12, thereby preventing the adoption of VB motor neuron fate (PubMed:10557206, PubMed:17289921).
May function with transcription factor mls-1 to promote uterine muscle specification and formation (PubMed:21852953).
In concert with unc-4, represses the expression of VB-specific genes such as ceh-12, thereby preventing the adoption of VB motor neuron fate (PubMed:10557206, PubMed:17289921).
May function with transcription factor mls-1 to promote uterine muscle specification and formation (PubMed:21852953).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Cellular Component | synapse | |
Cellular Component | transcription regulator complex | |
Molecular Function | RNA polymerase II-specific DNA-binding transcription factor binding | |
Molecular Function | transcription corepressor activity | |
Biological Process | chemical synaptic transmission | |
Biological Process | negative regulation of canonical Wnt signaling pathway | |
Biological Process | negative regulation of DNA-templated transcription | |
Biological Process | negative regulation of transcription by RNA polymerase II | |
Biological Process | regulation of axonogenesis | |
Biological Process | regulation of synapse organization | |
Biological Process | regulation of synapse structure or activity |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTranscription factor unc-37
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis
Accessions
- Primary accessionO02482
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
Maternal effect embryonic lethal (PubMed:21852953).
RNAi-mediated knockdown results in reduced uterine cell specification (PubMed:21852953).
Descendants of the ABa blastomere express lag-2 ectopically (PubMed:15935776).
RNAi-mediated knockdown results in reduced uterine cell specification (PubMed:21852953).
Descendants of the ABa blastomere express lag-2 ectopically (PubMed:15935776).
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 539 | In e262; movement defects, fertile. Abnormal, ectopic expression of ceh-12 in VA motor neurons. Inability to move backward is partially restored in an unc-12 mutant background. Ectopic expression of innexin unc-7 in puncta adjacent to VA motor neurons and DA class motor neurons, probably as a result of miswiring of gap junctions. | ||||
Sequence: H → Y |
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000051316 | 1-612 | Transcription factor unc-37 | |||
Sequence: MKASYLETLDRIKDEHAEMSKHVNQQRSDIEKVALEKENMNRSYMTYAEVSNTLRSDLRKAEEINKRLQEFIMQSLAPQLSQDNQANCLAALEAFKTASPRENGNGAPALPPGFPPGAAGMLGMMPNMPFGMSPAMSQLFNQFASPHVNGGDGAGGSSGGASEAKKAKLEDPDDGELEIDVTNDDHPSTASNGGAANKNGRDSTNSVASSGASTPSIASNSRARQQQQPLAGLQGLEQMNFLAGFNPNLLRQASAAGGFNFLNDPHAQARLAAAIGQIGSRPAYSFKIVDGGVPTPTSFPPDAQKGPGIPTGLKKKMELNHGEVVCAATISRDNSRVYTGGKGCVKIWDVKESDISGATVVNRPPIASLDCLKENYIRSCKLFEDGNTLLIGGEASTVALWDLTTETKTLDLETDSQACYALAMSPDEKLLFACLADGNILIYDIHNKVKVGTLPGHQDGASCLDLSKDGTKLWSGGLDNSVRCWDLAQRKEVAKHDFASQVFSLGCCPNDEWVAVGMENNYVEVLSTTGKEKYQLTQHESCVLSLKFAHSGKFFISTGKDNALNAWRTPYGASLFQLKENSSVLSCDISFDDSLIVTGSGEKKATLYAVEY |
Proteomic databases
Expression
Gene expression databases
Interaction
Subunit
Interacts with unc-4 (PubMed:10557206).
Interacts with ref-1 (PubMed:15935776).
May interact with mls-1 (PubMed:21852953).
Interacts with ref-1 (PubMed:15935776).
May interact with mls-1 (PubMed:21852953).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | O02482 | CELE_ZK1053.3 O62505 | 4 | EBI-314716, EBI-326955 | |
BINARY | O02482 | ces-1 G5ECN8 | 4 | EBI-314716, EBI-322161 | |
BINARY | O02482 | lsy-22 Q93616 | 7 | EBI-314716, EBI-2005589 | |
BINARY | O02482 | nhr-67 Q9XVV3 | 3 | EBI-314716, EBI-314697 | |
BINARY | O02482 | pax-3 G5ED66 | 5 | EBI-314716, EBI-2416749 | |
BINARY | O02482 | pop-1 Q10666 | 3 | EBI-314716, EBI-317870 | |
BINARY | O02482 | sptf-2 Q22678 | 5 | EBI-314716, EBI-2420648 | |
BINARY | O02482 | unc-130 Q18694 | 3 | EBI-314716, EBI-2414897 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 143-228 | Disordered | ||||
Sequence: FASPHVNGGDGAGGSSGGASEAKKAKLEDPDDGELEIDVTNDDHPSTASNGGAANKNGRDSTNSVASSGASTPSIASNSRARQQQQ | ||||||
Region | 153-196 | CCN domain | ||||
Sequence: GAGGSSGGASEAKKAKLEDPDDGELEIDVTNDDHPSTASNGGAA | ||||||
Compositional bias | 184-228 | Polar residues | ||||
Sequence: DDHPSTASNGGAANKNGRDSTNSVASSGASTPSIASNSRARQQQQ | ||||||
Repeat | 308-339 | WD 1 | ||||
Sequence: GIPTGLKKKMELNHGEVVCAATISRDNSRVYT | ||||||
Repeat | 372-402 | WD 2 | ||||
Sequence: LKENYIRSCKLFEDGNTLLIGGEASTVALWD | ||||||
Repeat | 414-444 | WD 3 | ||||
Sequence: TDSQACYALAMSPDEKLLFACLADGNILIYD | ||||||
Repeat | 456-486 | WD 4 | ||||
Sequence: GHQDGASCLDLSKDGTKLWSGGLDNSVRCWD | ||||||
Repeat | 538-568 | WD 5 | ||||
Sequence: QHESCVLSLKFAHSGKFFISTGKDNALNAWR | ||||||
Repeat | 579-609 | WD 6 | ||||
Sequence: KENSSVLSCDISFDDSLIVTGSGEKKATLYA |
Sequence similarities
Belongs to the WD repeat Groucho/TLE family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length612
- Mass (Da)65,617
- Last updated1997-07-01 v1
- ChecksumD3AFF39E526F8249
Features
Showing features for sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 66 | in Ref. 1; AAB49459 | ||||
Sequence: K → T | ||||||
Compositional bias | 184-228 | Polar residues | ||||
Sequence: DDHPSTASNGGAANKNGRDSTNSVASSGASTPSIASNSRARQQQQ |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U89245 EMBL· GenBank· DDBJ | AAB49459.1 EMBL· GenBank· DDBJ | mRNA | ||
AF001271 EMBL· GenBank· DDBJ | AAB84234.1 EMBL· GenBank· DDBJ | mRNA | ||
AF001272 EMBL· GenBank· DDBJ | AAB84235.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FO081084 EMBL· GenBank· DDBJ | CCD68992.1 EMBL· GenBank· DDBJ | Genomic DNA |