O02482 · UNC37_CAEEL

  • Protein
    Transcription factor unc-37
  • Gene
    unc-37
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Transcriptional corepressor that functions with the neural specificity gene unc-4 to govern motor neuron identity (PubMed:10557206, PubMed:17289921, PubMed:9165118).
In concert with unc-4, represses the expression of VB-specific genes such as ceh-12, thereby preventing the adoption of VB motor neuron fate (PubMed:10557206, PubMed:17289921).
May function with transcription factor mls-1 to promote uterine muscle specification and formation (PubMed:21852953).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Cellular Componentsynapse
Cellular Componenttranscription regulator complex
Molecular FunctionRNA polymerase II-specific DNA-binding transcription factor binding
Molecular Functiontranscription corepressor activity
Biological Processchemical synaptic transmission
Biological Processnegative regulation of canonical Wnt signaling pathway
Biological Processnegative regulation of DNA-templated transcription
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processregulation of axonogenesis
Biological Processregulation of synapse organization
Biological Processregulation of synapse structure or activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Transcription factor unc-37
  • Alternative names
    • Uncoordinated protein 37

Gene names

    • Name
      unc-37
    • Synonyms
      esg
    • ORF names
      W02D3.9

Organism names

  • Taxonomic identifier
  • Strain
    • Bristol N2
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis

Accessions

  • Primary accession
    O02482
  • Secondary accessions
    • P91912

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

Maternal effect embryonic lethal (PubMed:21852953).
RNAi-mediated knockdown results in reduced uterine cell specification (PubMed:21852953).
Descendants of the ABa blastomere express lag-2 ectopically (PubMed:15935776).

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis539In e262; movement defects, fertile. Abnormal, ectopic expression of ceh-12 in VA motor neurons. Inability to move backward is partially restored in an unc-12 mutant background. Ectopic expression of innexin unc-7 in puncta adjacent to VA motor neurons and DA class motor neurons, probably as a result of miswiring of gap junctions.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000513161-612Transcription factor unc-37

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Interacts with unc-4 (PubMed:10557206).
Interacts with ref-1 (PubMed:15935776).
May interact with mls-1 (PubMed:21852953).

Binary interactions

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias, repeat.

TypeIDPosition(s)Description
Region143-228Disordered
Region153-196CCN domain
Compositional bias184-228Polar residues
Repeat308-339WD 1
Repeat372-402WD 2
Repeat414-444WD 3
Repeat456-486WD 4
Repeat538-568WD 5
Repeat579-609WD 6

Sequence similarities

Belongs to the WD repeat Groucho/TLE family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    612
  • Mass (Da)
    65,617
  • Last updated
    1997-07-01 v1
  • Checksum
    D3AFF39E526F8249
MKASYLETLDRIKDEHAEMSKHVNQQRSDIEKVALEKENMNRSYMTYAEVSNTLRSDLRKAEEINKRLQEFIMQSLAPQLSQDNQANCLAALEAFKTASPRENGNGAPALPPGFPPGAAGMLGMMPNMPFGMSPAMSQLFNQFASPHVNGGDGAGGSSGGASEAKKAKLEDPDDGELEIDVTNDDHPSTASNGGAANKNGRDSTNSVASSGASTPSIASNSRARQQQQPLAGLQGLEQMNFLAGFNPNLLRQASAAGGFNFLNDPHAQARLAAAIGQIGSRPAYSFKIVDGGVPTPTSFPPDAQKGPGIPTGLKKKMELNHGEVVCAATISRDNSRVYTGGKGCVKIWDVKESDISGATVVNRPPIASLDCLKENYIRSCKLFEDGNTLLIGGEASTVALWDLTTETKTLDLETDSQACYALAMSPDEKLLFACLADGNILIYDIHNKVKVGTLPGHQDGASCLDLSKDGTKLWSGGLDNSVRCWDLAQRKEVAKHDFASQVFSLGCCPNDEWVAVGMENNYVEVLSTTGKEKYQLTQHESCVLSLKFAHSGKFFISTGKDNALNAWRTPYGASLFQLKENSSVLSCDISFDDSLIVTGSGEKKATLYAVEY

Features

Showing features for sequence conflict, compositional bias.

TypeIDPosition(s)Description
Sequence conflict66in Ref. 1; AAB49459
Compositional bias184-228Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U89245
EMBL· GenBank· DDBJ
AAB49459.1
EMBL· GenBank· DDBJ
mRNA
AF001271
EMBL· GenBank· DDBJ
AAB84234.1
EMBL· GenBank· DDBJ
mRNA
AF001272
EMBL· GenBank· DDBJ
AAB84235.1
EMBL· GenBank· DDBJ
Genomic DNA
FO081084
EMBL· GenBank· DDBJ
CCD68992.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp