O01761 · UNC89_CAEEL
- ProteinMuscle M-line assembly protein unc-89
- Geneunc-89
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids8081 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Structural component of the muscle M line which is involved in assembly and organization of sarcomere myofilaments (PubMed:15313609, PubMed:16453163, PubMed:18801371, PubMed:22621901, PubMed:23283987, PubMed:27009202).
The large isoform a, isoform b, isoform d and isoform f play an essential role in maintaining the organization of sarcomeres but not myofilament alignment during body wall muscle development whereas the small isoform c and isoform d appear to have a minor role (PubMed:15313609, PubMed:16453163, PubMed:22768340).
Isoform b and isoform f are required for the organization of unc-15/paramyosin into sarcomere thick filaments in body wall muscles (PubMed:27009202).
By binding mel-26, a substrate adapter of the cul-3 E3 ubiquitin-protein ligase complex, regulates the organization of myosin thick filaments, likely by preventing the degradation of microtubule severing protein mei-1 (PubMed:22621901).
Acts as a guanine nucleotide exchange factor (GEF) for Rho GTPase rho-1 but not ced-10, mig-2 and cdc-42 (PubMed:18801371).
The large isoforms regulate Ca2+ signaling during muscle contraction by ensuring the correct localization of sarco-endoplamic reticulum Ca2+ ATPase sca-1 and ryanodine receptor unc-68 (PubMed:22768340).
By controlling the contraction and/or organization of pharyngeal muscles, plays a role in the formation of pharyngeal gland cell extension (PubMed:21868609).
The large isoform a, isoform b, isoform d and isoform f play an essential role in maintaining the organization of sarcomeres but not myofilament alignment during body wall muscle development whereas the small isoform c and isoform d appear to have a minor role (PubMed:15313609, PubMed:16453163, PubMed:22768340).
Isoform b and isoform f are required for the organization of unc-15/paramyosin into sarcomere thick filaments in body wall muscles (PubMed:27009202).
By binding mel-26, a substrate adapter of the cul-3 E3 ubiquitin-protein ligase complex, regulates the organization of myosin thick filaments, likely by preventing the degradation of microtubule severing protein mei-1 (PubMed:22621901).
Acts as a guanine nucleotide exchange factor (GEF) for Rho GTPase rho-1 but not ced-10, mig-2 and cdc-42 (PubMed:18801371).
The large isoforms regulate Ca2+ signaling during muscle contraction by ensuring the correct localization of sarco-endoplamic reticulum Ca2+ ATPase sca-1 and ryanodine receptor unc-68 (PubMed:22768340).
By controlling the contraction and/or organization of pharyngeal muscles, plays a role in the formation of pharyngeal gland cell extension (PubMed:21868609).
GO annotations
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMuscle M-line assembly protein unc-89
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis
Accessions
- Primary accessionO01761
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Colocalizes with scpl-1 (isoform b) to the M line (PubMed:19244614).
Colocalizes with cpna-1 to the M line (PubMed:23283987).
Colocalizes with mel-26 to the M line (PubMed:22621901).
Accumulates at the center of thick myofilaments in M line-like structures in myoepithelial sheath cells (PubMed:17326220).
Colocalizes with cpna-1 to the M line (PubMed:23283987).
Colocalizes with mel-26 to the M line (PubMed:22621901).
Accumulates at the center of thick myofilaments in M line-like structures in myoepithelial sheath cells (PubMed:17326220).
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Mutants lacking isoform a, isoform b, isoform e and isoform f have an abnormal organization of the myofilament lattice of body wall and pharyngeal muscles (PubMed:16453163, PubMed:18801371, PubMed:22621901, PubMed:27009202).
In body wall muscles, unc-15/paramyosin accumulates in large foci outside thick filaments and myosin heavy chains unc-54 and myo-3 fail to assemble into parallel myofibrils (PubMed:27009202).
In addition, myosin thick filaments are disorganized with the formation of abnormal myosin heavy chain myo-3 aggregates and V-shaped crossing of A bands (PubMed:18801371, PubMed:22621901).
In mutants lacking isoform b, isoform c, isoform d and isoform f, myo-3 fails to assemble into parallel myofibrils whereas unc-54 and unc-15 localization is normal (PubMed:27009202).
Mutants lacking isoform b, isoform c, isoform d and isoform f have defects only in body wall muscle structure (PubMed:16453163).
RNAi-mediated knockdown of isoform a or isoform b, isoform c and isoform d causes similar defects in the organization although RNAi-mediated knockdown of isoform c causes a less severe defect in myofilament organization (PubMed:15313609).
In mutants lacking isoform a, isoform b, isoform e and isoform f, mei-1 protein levels are decreased by 20 percent (PubMed:22621901).
RNAi-mediated knockdown of isoform a, isoform b, isoform e and isoform f but not of isoforms c and d disrupts sca-1 localization to linear punctate structures along in the M line in body wall muscles (PubMed:22768340).
RNAi-mediated knockdown has no effect on ovulation (PubMed:17326220).
In body wall muscles, unc-15/paramyosin accumulates in large foci outside thick filaments and myosin heavy chains unc-54 and myo-3 fail to assemble into parallel myofibrils (PubMed:27009202).
In addition, myosin thick filaments are disorganized with the formation of abnormal myosin heavy chain myo-3 aggregates and V-shaped crossing of A bands (PubMed:18801371, PubMed:22621901).
In mutants lacking isoform b, isoform c, isoform d and isoform f, myo-3 fails to assemble into parallel myofibrils whereas unc-54 and unc-15 localization is normal (PubMed:27009202).
Mutants lacking isoform b, isoform c, isoform d and isoform f have defects only in body wall muscle structure (PubMed:16453163).
RNAi-mediated knockdown of isoform a or isoform b, isoform c and isoform d causes similar defects in the organization although RNAi-mediated knockdown of isoform c causes a less severe defect in myofilament organization (PubMed:15313609).
In mutants lacking isoform a, isoform b, isoform e and isoform f, mei-1 protein levels are decreased by 20 percent (PubMed:22621901).
RNAi-mediated knockdown of isoform a, isoform b, isoform e and isoform f but not of isoforms c and d disrupts sca-1 localization to linear punctate structures along in the M line in body wall muscles (PubMed:22768340).
RNAi-mediated knockdown has no effect on ovulation (PubMed:17326220).
PTM/Processing
Features
Showing features for chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000072704 | 1-8081 | Muscle M-line assembly protein unc-89 | |||
Sequence: MASRRQKQFDRKYSSYRKFTATEDVNYSTHSSRSSYRSESLTSRTDGRGRSTSSEIIAGSESRSYPVYIAIQDYTPDKEDVEAIPLEQGQIVEVLDKKNSVRWLVRTKARPPRSGWVPGSYFETPTEFYKQRRRTREIENVSLSDEQAALVKRDQVYHELLRSEEEFVSSLRTCVDDYIKVLDDPEVPEAVKKNREELTLNIPELYNFHANVMLKGLNYYSDDPGKVGQTFVRLEKDFESHVEFYKQYADTLKLLEEPEIKRFFEGLSAKNDAGASSFVDHVKEIADRMVQYQNYFKEFVKYSARAHGSSKSIQKALELVTTIPQRVHDLEFTNNLKQHPGDTGKLGRIIRHDAFQVWEGDEPPKLRYVFLFRNKIMFTEQDASTSPPSYTHYSSIRLDKYNIRQHTTDEDTIVLQPQEPGLPSFRIKPKDFETSEYVRKAWLRDIAEEQEKYAAERDAISMTATSEMTASSVDFDMNASDQQSEFSEWSGSRKSSLFPGPEEGGPPRKKVKSPPVISPTGSSTSIYSGGSSSIDWTTTGTTLEMQGTRVTRTQYGFRTLQESSAKMCLKVTGYPLPDITWYKDDVQLHEDERHTFYSDEDGFFAMTIDPVQVTDTGRYTCMATNEYGQASTSAFFRVLKVEKEAAPPAFVTKLRDKECKEGDVIDFECEVEGWPEPELVWLVDDQPLRPSHDFRLQYDGQTAKLEIRDAQPDDTGVYTVKIQNEFGSIESKAELFVQADPDKNHVAPEFQATIEYVECDEGEEVRFKSVITGDPNPEIIWFINGKPLSESEKVKFISEDGICILTIKDVTRHFDGMVTCQGSNRLGSASCDGRLKVRVPPAPPTFNKPLEDKTVQEKSTVVFEVDVSGWPEPTLTFTLCGKELKNGEEGVEIVGHDGFYRISIPNTSMDKHDGEIVAKAQNEHGTAESRARLTVEQEEEESRSAPTFLKDIEDQTVKTGEFAVFETTVRGNPNPEVTWFINGHKMDQGSPGVKIEAHNHDHKLTIDSAQYAGTVLCRAENAVGRFETKARLVVLAPEKQKKPPKFVEILVDKTETVDNTVVFEVRVEGEPKPTVTWYLKGEELKQSDRVEIREFDGSIKISIKNIKIEDAGEIRAVATNSEGSDETKAKLTVQKKPFAPEFDLRPVSLTVEKGSEAVFSAHAFGIPLPTYEWSVNGRKVRDGQEGARVTRDESTVDGASILTIDTATYYSEVNHLTISVVAENTLGAEETGAQLTIEPKKESVVVEKQDLSSSEVQKEIAQQVKEASPEATTTITMETSLTSTKTTTMSTTEVTSTVGGVTVETKESESESATTVIGGGSGGVTEGSISVSKIEVVSKTDSQTDVREGTPKRRVSFAEEELPKEVIDSDRKKKKSPSPDKKEKSPEKTEEKPASPTKKTGEEVKSPKEKSPASPTKKEKSPAAEEVKSPTKKEKSPSSPTKKEKSPSSPTKKTGDEVKEKSPPKSPTKKEKSPEKPEDVKSPVKKEKSPDATNIVEVSSETTIEKTETTMTTEMTHESEESRTSVKKEKTPEKVDEKPKSPTKKDKSPEKSITEEIKSPVKKEKSPEKVEEKPASPTKKEKSPEKPASPTKKSENEVKSPTKKEKSPEKSVVEELKSPKEKSPEKADDKPKSPTKKEKSPEKSATEDVKSPTKKEKSPEKVEEKPTSPTKKESSPTKKTDDEVKSPTKKEKSPQTVEEKPASPTKKEKSPEKSVVEEVKSPKEKSPEKAEEKPKSPTKKEKSPEKSAAEEVKSPTKKEKSPEKSAEEKPKSPTKKESSPVKMADDEVKSPTKKEKSPEKVEEKPASPTKKEKTPEKSAAEELKSPTKKEKSPSSPTKKTGDESKEKSPEKPEEKPKSPTPKKSPPGSPKKKKSKSPEAEKPPAPKLTRDLKLQTVNKTDLAHFEVVVEHATECKWFLDGKEITTAQGVTVSKDDQFEFRCSIDTTMFGSGTVSVVASNAAGSVETKTELKVLETPKETKKPEFTDKLRDMEVTKGDTVQMDVIALHSPLYKWYQNGNLLEDGKNGVTIKNEENKSSLIIPNAQDSGKITVEASNEVGSSESSAQLTVNPPSTTPIVVDGPKSVTIKETETAEFKATISGFPAPTVKWTINEKIVEESRTITTIKTEDVYTLKISNAKIEQTGTVKVTAQNSAGQDSKQADLKVEPNVKAPKFKSQLTDKVADEGEPLRWNLELDGPSPGTEVSWLLNGQPLTKSDTVQVVDHGDGTYHVTIAEAKPEMSGTLTAKAKNAAGECETSAKVTVNGGNKKPEFVQAPQNHETTLEESVKFSAIVTGKPMPNVTWYLNNKKLIQSEEVKVKYVHETGKTSIRIQKPLMEHNGTIRVEAENVSGKVQATAQLKVDKKTEVPKFTTNMDDRQVKEGEDVKFTANVEGYPEPSVAWTLNGEPVSKHPNITVTDKDGEHTIEISAVTPEQAGELSCEATNPVGSKKRDVQLAVKKVGDAPTFAKNLEDRLITEGELTLMDAKLNIVKPKPKITWLKDGVEITSDGHYKIVEEEDGSLKLSILQTKLEDKGRITIKAESEFGVAECSASLGVVKGRPMAKPAFQSDIAPINLTEGDTLECKLLITGDPTPFVKWYIGTQLVCATEDTEISNANGVYTMKIHGVTADMTGKIKCVAYNKAGEVSTEGPLKVVAPIPVEFETSLCDATCREGDTLKLRAVLLGEPEPVVSWYVNGKKLEESQNIKIHSEKGTYTVTIKDITCDYSGQVVCEAINEYGKATSEATLLVLPRGEPPDFLEWLSNVRARTGTKVVHKVVFTGDPKPSLTWYINNKEILNSDLYTIVTDDKTSTLTINSFNPDVHVGEIICKAENDAGEVSCTANMITYTSDMFSESESEAQAEEFVGDDLTEDESLREEMHRTPTPVMAPKFITKIKDTKAKKGHSAVFECVVPDTKGVCCKWLKDGKEIELIARIRVQTRTGPEGHITQELVLDNVTPEDAGKYTCIVENTAGKDTCEATLTVIESLEKKSEKKAPEFIVALQDKTTKTSEKVVLECKVIGEPKPKVSWLHDNKTITQESITVESVEGVERVTITSSELSHQGKYTCIAENTEGTSKTEAFLTVQGEAPVFTKELQNKELSIGEKLVLSCSVKGSPQPHVDFYSFSETTKVETKITSSSRIAIEHDQTNTHWRMVISQITKEDIVSYKAIATNSIGTATSTSKITTKVEAPVFEQGLKKTSVKEKEEIKMEVKVGGSAPDVEWFKDDKPVSEDGNHEMKKNPETGVFTLVVKQAATTDAGKYTAKASNPAGTAESSAEAEVTQSLEKPTFVRELVTTEVKINETATLSVTVKGVPDPSVEWLKDGQPVQTDSSHVIAKVEGSGSYSITIKDARLEDSGKYACRATNPAGEAKTEANFAVVKNLVPPEFVEKLSPLEVKEKESTTLSVKVVGTPEPSVEWFKDDTPISIDNVHVIQKQTAVGSFSLTINDARQGDVGIYSCRARNEAGEALTTANFGIIRDSIPPEFTQKLRPLEVREQETLDLKVTVIGTPVPNVEWFKDDKPINIDNSHIFAKDEGSGHHTLTIKQARGEDVGVYTCKATNEAGEAKTTANMAVQEEIEAPLFVQGLKPYEVEQGKPAELVVRVEGKPEPEVKWFKDGVPIAIDNQHVIEKKGENGSHTLVIKDTNNADFGKYTCQATNKAGKDETVGELKIPKYSFEKQTAEEVKPLFIEPLKETFAVEGDTVVLECKVNKESHPQIKFFKNDQPVEIGQHMQLEVLEDGNIKLTIQNAKKEDVGAYRCEAVNVAGKANTNADLKIQFAAKVEEHVTDESGQLEEIGQFETVGDTASSKTDTGRGAPEFVELLRSCTVTEKQQAILKCKVKGEPRPKIKWTKEGKEVEMSARVRAEHKDDGTLTLTFDNVTQADAGEYRCEAENEYGSAWTEGPIIVTLEGAPKIDGEAPDFLQPVKPAVVTVGETAVLEGKISGKPKPSVKWYKNGEELKPSDRVKIENLDDGTQRLTVTNAKLDDMDEYRCEASNEFGDVWSDVTLTVKEPAQVAPGFFKELSAIQVKETETAKFECKVSGTKPDVKWFKDGTPLKEDKRVHFESTDDGTQRLVIEDSKTDDQGNYRIEVSNDAGVANSKVPLTVVPSETLKIKKGLTDVNVTQGTKILLSVEVEGKPKTVKWYKGTETVTSSQTTKIVQVTESEYKLEIESAEMSDTGAYRVVLSTDSFSVESSATVTVTKAAEKISLPSFKKGLADQSVPKGTPLVLEVEIEGKPKDVKWYKNGDEIKDGKVEDLGNGKYRLTIPDFQEKDVGEYSVTAANEAGEIESKAKVNVSAKPEIVSGLVPTTVKQGETATFNVKVKGPVKGVKWYKNGKEIPDAKTKDNGDGSYSLEIPNAQVEDAADYKVVVSNDAGDADSSAALTVKLADDGKDKVKPEIVSGLIPTTVKQGETATFNVKVKGPVKQVKWYKNGKEIPNAKAKDNGDGSYSLEIPNAQLDDTADYKVVVSNDAGDADSSAALTVKLPGIAIVKGLEDAEVPKGKKAVLQVETNKKPKEIKWYKNGKEITPSDKAQPGSDGDNKPQLVIPDAGDDDAAEYKVVLTDEDGNTADSSCALTVKLPAKEPKIIKGLEDQVVSIGSPIKLEIETSGSPKTVKWYKNGKELPGAAAKTIKIQKIDDNKYVLEIPSSVVEDTGDYKVEVANEAGSANSSGKITVEPKITFLKPLKDQSITEGENAEFSVETNTKPRIVKWYKNGQEIKPNSRFIIEQKTDTKYQLVIKNAVRDDADTYKIVLENTAGEAESSAQLTVKKAKAGLCKIVKGLEDQVVAKGAKMVFEVKIQGEPEDVRWLRDANVISAGANAIIEKIDDTTYRLIIPSADLKDAGEYTVEVINESGKAKSDAKGEVDEKPEIVRGLENIEIPEGDDDVFKVEVSAPVRQVKWYKNDQEIKPNSHLEAKKIGPKKYELAINRAQLDDGADYKVVLSNAAGDCDSSAALTVVKPNVLKIVDGLKDVDVEEPQPVELKVKVEGIPKVIKWYKNGQELKPDADGFKFEEKPESGEFSLTIPSSKKSDGGAYRVVLGNDKGEVYSGSVVHVKSAKSSEPTSGANFLSPLKDTEVEEGDMLTLQCTIAGEPFPEVIWEKDGVVLQKDDRITMRVALDGTATLRIRSAKKSDIGQYRVTAKNEAGSATSDCKVTVTEQGEQPSKPKFVIPLKTGAALPGDKKEFNVKVRGLPKPTLQWFLNGIPIKFDDRITLDDMADGNYCLTIRDVREEDFGTLKCIAKNENGTDETVCEFQQGAGHDDGSRDDLRYPPRFNVPLWDRRIPVGDPMFIECHVDANPTAEVEWFKDGKKIEHTAHTEIRNTVDGACRIKIIPFEESDIGVYMCVAVNELGQAETQATYQVEILEHVEEEKRREYAPKINPPLEDKTVNGGQPIRLSCKVDAIPRASVVWYKDGLPLRADSRTSIQYEEDGTATLAINDSTEEDIGAYRCVATNAHGTINTSCSVNVKVPKQEVKKEGEEPFFTKGLVDLWADRGDSFTLKCAVTGDPFPEIKWYRNGQLLRNGPRTVIETSPDGSCSLTVNESTMSDEGIYRCEAENAHGKAKTQATAHVQMALGKTEKPKMDEGKPPKFILELSDMSVSLGNVIDLECKVTGLPNPSVKWSKDGGPLIEDSRFEWSNEASKGVYQLRIKNATVHDEGTYRCVATNENGSATTKSFVRMDDGLGSGVVTASQPPRFTLKMGDVRTTEGQPLKLECKVDASPLPEMVWYKDGAIVTPSDRIQISLSPDGVATLLIPSCVYDDDGIYRVIATNPSGTAQDKGTATVKKLPRDSGARRSADRDVFDANKAPKLMEPLENIRIPEKQSFRLRCKFSGDPKPTIKWFKDGERVFPYGRLQLIESPDGVCELVVDSATRQDAGGYRCVAENTYGSARTSCDVNVIRGDRKPRDIDSSIREGKAPGFTTPLTIRRAKPGDSVTFECLPFGNPFPSIKWLKDGLELFSDEKIKMEAAADGTQRLILSDVTFLSEGYFRCVATNEHGTASTKAELVIEGDRTIGSRPLPEVNGEPEECKPRIRRGLYNMSIHEGNVVEMIVCATGIPTPTVKWYKDGQEIVGDGPDGKRVIFTDERGIHHLVIVNASPDDEGEYSLEATNKLGSAKTEGSLNIIRPRHIADADERGGMPFPPGFVRQLKNKHVFNHMPTIFDCLVVGHPAPEVEWFHNGKKIVPGGRIKIQSCGGGSHALIILDTTLEDAGEYVATAKNSHGSASSSAVLDVTVPFLDSIKFNGEIDVTPYLTEEYGFKKLNTASLPTPPDRGPFIKEVTGHYLTLSWIPTKRAPPRYPQVTYVIEIRELPEKQWSLLEYNIPEPVCKVRNLELGKSYQFRVRAENIYGISDPSPASPPSRLMAPPQPVFDRRTNKVIPLLDPYAEKALDMRYSEQYACAPWFSPGVVEKRYCAENDTLTIVLNVSGFPDPDIKWKFRGWDIDTSSPTSKCKVYTYGGSETTLAITGFSKENVGQYQCFAKNDYGDAQQNIMVDLATRPNFIQPLVNKTFSSAQPMRMDVRVDGEPFPELKWMKEWRPIVESSRIKFVQDGPYLCSLIINDPMWRDSGIYSCVAVNDAGQATTSCTVTVEAEGDYNDVELPRRRVTIESRRVRELYEISEKDEKLAAEGAPFRVKEKATGREFLAQLRPIDDALMRHVDIHNSLDHPGIVQMHRVLRDEKLALVVFDNANSTIDGLSSLAHPGVEIAEPKGVNRETCVRVFVRQLLLALKHMHDLRIAHLDLRPETILLQDDKLKLADFGQARRLLRGLITGEIKGSPEFVSPEIVRSYPLTLATDMWSTGVLTYVLLTGLSPFHGDNDNETLANVDSCQFDSSPLGNFSYDAGDFVKKLLTEIPVSRLTVDEALDHPWINDEKLKTEPLSADTLREFKYQHKWLERRVFVQQTPSEQILEAILGPATAQAQQNAPVAPEGRRPAEIYDYLRIQPKKPPPTVEYVPQPRKEHPPFIDEFGQLIDGDAFDRPEGTGFEGPHRQPPQIPPQPQRPNQAAHDSRRHEQQPQHQGQPQRIPVDQYGRPLVDPRYLNDPSHRPSSLDDAPFYVDKYGNPVHFDKYGRPMAPQNLEKRKLIPQDKGETPSHSKKEKTQHPVATPILASPGGDQQQQKIPMRMIRGERREIEEEIANRILSDISEEGSIAGSLASLEDFEIPKDFQVEASEPSTPTLTPEVTIRETIPKPTPSPTSPQKSPVPQPQGLLIPAKVTYSDSILAGLPAADKKVLEDAENDPSIPVGAPLFLEGLHGSDLTIDTTSASGLIKVTSPAINLSPNPKSPRRSTPGTKSPVVLSPRQEHSMEVLIATKRGKPGFLPPGELAEDIDDEDAFMDDRKKQVKPKDHDGENDFKDEKERLEKDKNRRTVNLDDLDKYRPSAFYKDDSDFGHPGYDIDATPWDSHYQIGPDTYLMAARGAAFNSRVRNYREELFGMGAPTVKQGFLGVRNRDITVRERRRYTDILRETTQGLEPKSHEQSTALLQKAPSATAIERIKADIEKVTPCATKKNDDGTFAPIFTARLRDVYLRKNQPAIFECAVSASPAPKVTWDFQGKILESNDRVTIEQDNNVARLILNHAAPYDLGEYVCTAINEYGTDKSSCRLISGETPSRPGRPEAELSSDTEIFIQWEAPEGPTYLEGITYRLEYRVAGPNDHGDPWITVSEKIDDESVIVKHLSPLGIYQFRVTAQNGFGLGLPSLSSRIVQTHGKGAPKLQIDVLKSEIRLNVVSMPQKSTNQLGGISEESEEDSEARTANEDMKSNLQLQTDDPTGRFQIGGLKFKGRFSVIRDAVDSTTEGHAHCAVKIRHPSSEAISEYESLRDGQHENVQRLIAAFNNSNFLYLLSERLYEDVFSRFVFNDYYTEEQVALTMRQVTSALHFLHFKGIAHLDVNPHNIMFQSKRSWVVKLVDFGRAQKVSGAVKPVDFDTKWASPEFHIPETPVTVQSDMWGMGVVTFCLLAGFHPFTSEYDREEEIKENVINVKCDPNLIPVNASQECLSFATWALKKSPVRRMRTDEALSHKFLSSDPSMVRRRESIKYSASRLRKLAAMIRQPTFSQPISEELESKYGK | ||||||
Disulfide bond | 568↔621 | |||||
Sequence: CLKVTGYPLPDITWYKDDVQLHEDERHTFYSDEDGFFAMTIDPVQVTDTGRYTC | ||||||
Disulfide bond | 2582↔2635 | |||||
Sequence: CKLLITGDPTPFVKWYIGTQLVCATEDTEISNANGVYTMKIHGVTADMTGKIKC | ||||||
Disulfide bond | 2908↔2964 | |||||
Sequence: CVVPDTKGVCCKWLKDGKEIELIARIRVQTRTGPEGHITQELVLDNVTPEDAGKYTC | ||||||
Disulfide bond | 3015↔3065 | |||||
Sequence: CKVIGEPKPKVSWLHDNKTITQESITVESVEGVERVTITSSELSHQGKYTC | ||||||
Disulfide bond | 3707↔3759 | |||||
Sequence: CKVNKESHPQIKFFKNDQPVEIGQHMQLEVLEDGNIKLTIQNAKKEDVGAYRC | ||||||
Disulfide bond | 3838↔3890 | |||||
Sequence: CKVKGEPRPKIKWTKEGKEVEMSARVRAEHKDDGTLTLTFDNVTQADAGEYRC | ||||||
Disulfide bond | 5298↔5350 | |||||
Sequence: CHVDANPTAEVEWFKDGKKIEHTAHTEIRNTVDGACRIKIIPFEESDIGVYMC | ||||||
Disulfide bond | 5404↔5456 | |||||
Sequence: CKVDAIPRASVVWYKDGLPLRADSRTSIQYEEDGTATLAINDSTEEDIGAYRC | ||||||
Disulfide bond | 5508↔5560 | |||||
Sequence: CAVTGDPFPEIKWYRNGQLLRNGPRTVIETSPDGSCSLTVNESTMSDEGIYRC | ||||||
Disulfide bond | 5616↔5669 | |||||
Sequence: CKVTGLPNPSVKWSKDGGPLIEDSRFEWSNEASKGVYQLRIKNATVHDEGTYRC | ||||||
Disulfide bond | 5836↔5888 | |||||
Sequence: CKFSGDPKPTIKWFKDGERVFPYGRLQLIESPDGVCELVVDSATRQDAGGYRC | ||||||
Disulfide bond | 5946↔5998 | |||||
Sequence: CLPFGNPFPSIKWLKDGLELFSDEKIKMEAAADGTQRLILSDVTFLSEGYFRC | ||||||
Disulfide bond | 7549↔7600 | |||||
Sequence: CAVSASPAPKVTWDFQGKILESNDRVTIEQDNNVARLILNHAAPYDLGEYVC |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in body-wall, pharyngeal muscles and a few muscle cells of the tail (at protein level) (PubMed:18337465, PubMed:19244614, PubMed:22621901, PubMed:22768340, PubMed:23283987, PubMed:27009202, PubMed:8603916).
Expressed in gonadal myoepithelial sheath cells (at protein level) (PubMed:17326220).
Isoform c: Expressed in body wall and vulval muscles but not in pharyngeal muscles (PubMed:15313609).
Isoform d: Specifically expressed in vulval, intestinal, anal depressor and anal sphincter muscles (PubMed:15313609).
Expressed in gonadal myoepithelial sheath cells (at protein level) (PubMed:17326220).
Isoform c: Expressed in body wall and vulval muscles but not in pharyngeal muscles (PubMed:15313609).
Isoform d: Specifically expressed in vulval, intestinal, anal depressor and anal sphincter muscles (PubMed:15313609).
Developmental stage
Expressed in embryos (PubMed:23283987).
Isoform a: Expressed in embryo, throughout larval development and in adults (PubMed:15313609).
Isoform b: Expressed in embryo, throughout larval development and in adults and is one of the most abundant (PubMed:15313609).
Isoform c: Expressed in embryo, throughout larval development and in adults and is one of the most abundant (PubMed:15313609).
Isoform d: Expressed in embryo, throughout larval development and in adults (PubMed:15313609).
Isoform a: Expressed in embryo, throughout larval development and in adults (PubMed:15313609).
Isoform b: Expressed in embryo, throughout larval development and in adults and is one of the most abundant (PubMed:15313609).
Isoform c: Expressed in embryo, throughout larval development and in adults and is one of the most abundant (PubMed:15313609).
Isoform d: Expressed in embryo, throughout larval development and in adults (PubMed:15313609).
Gene expression databases
Interaction
Subunit
May interact (via fibronectin type-III domain 1, Ig-like C2-type domain 48/49 and protein kinase domain 1 or C-terminus of the interkinase region) with lim-9 (via LIM zinc-binding domain) (PubMed:19244614).
May interact (via fibronectin type-III domain 1, Ig-like C2-type domain 48/49 and kinase protein domain 1 or Ig-like C2-type domain 50, fibronectin type-III domain 2 and kinase protein domain 2) with scpl-1 isoforms a and b (via FCP1 homology domain); the interaction may act as a molecular bridge to bring two unc-89 molecules together or to stabilize a loop between the 2 kinase domains (PubMed:18337465, PubMed:19244614).
May interact (via SH3 domain) with unc-15 (PubMed:27009202).
May interact (via Ig-like C2-type domain 1-3) with cpna-1 (via VWFA domain) (PubMed:23283987).
May interact (via Ig-like C2-type domain 2/3 and, Ig-like C2-type domain 50 and fibronectin type-III domain 2) with mel-26 (via MATH domain) (PubMed:22621901).
May interact (via DH and PH domains) with rho-1, ced-10, mig-2 and cdc-42 (PubMed:18801371).
May interact (via fibronectin type-III domain 1, Ig-like C2-type domain 48/49 and kinase protein domain 1 or Ig-like C2-type domain 50, fibronectin type-III domain 2 and kinase protein domain 2) with scpl-1 isoforms a and b (via FCP1 homology domain); the interaction may act as a molecular bridge to bring two unc-89 molecules together or to stabilize a loop between the 2 kinase domains (PubMed:18337465, PubMed:19244614).
May interact (via SH3 domain) with unc-15 (PubMed:27009202).
May interact (via Ig-like C2-type domain 1-3) with cpna-1 (via VWFA domain) (PubMed:23283987).
May interact (via Ig-like C2-type domain 2/3 and, Ig-like C2-type domain 50 and fibronectin type-III domain 2) with mel-26 (via MATH domain) (PubMed:22621901).
May interact (via DH and PH domains) with rho-1, ced-10, mig-2 and cdc-42 (PubMed:18801371).
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, domain, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 24-57 | Disordered | ||||
Sequence: DVNYSTHSSRSSYRSESLTSRTDGRGRSTSSEII | ||||||
Domain | 63-127 | SH3 | ||||
Sequence: RSYPVYIAIQDYTPDKEDVEAIPLEQGQIVEVLDKKNSVRWLVRTKARPPRSGWVPGSYFETPTE | ||||||
Domain | 152-330 | DH | ||||
Sequence: KRDQVYHELLRSEEEFVSSLRTCVDDYIKVLDDPEVPEAVKKNREELTLNIPELYNFHANVMLKGLNYYSDDPGKVGQTFVRLEKDFESHVEFYKQYADTLKLLEEPEIKRFFEGLSAKNDAGASSFVDHVKEIADRMVQYQNYFKEFVKYSARAHGSSKSIQKALELVTTIPQRVHDL | ||||||
Domain | 342-498 | PH | ||||
Sequence: DTGKLGRIIRHDAFQVWEGDEPPKLRYVFLFRNKIMFTEQDASTSPPSYTHYSSIRLDKYNIRQHTTDEDTIVLQPQEPGLPSFRIKPKDFETSEYVRKAWLRDIAEEQEKYAAERDAISMTATSEMTASSVDFDMNASDQQSEFSEWSGSRKSSLF | ||||||
Compositional bias | 479-494 | Polar residues | ||||
Sequence: ASDQQSEFSEWSGSRK | ||||||
Region | 479-531 | Disordered | ||||
Sequence: ASDQQSEFSEWSGSRKSSLFPGPEEGGPPRKKVKSPPVISPTGSSTSIYSGGS | ||||||
Compositional bias | 516-531 | Polar residues | ||||
Sequence: VISPTGSSTSIYSGGS | ||||||
Domain | 547-633 | Ig-like C2-type 1 | ||||
Sequence: GTRVTRTQYGFRTLQESSAKMCLKVTGYPLPDITWYKDDVQLHEDERHTFYSDEDGFFAMTIDPVQVTDTGRYTCMATNEYGQASTS | ||||||
Domain | 648-736 | Ig-like C2-type 2 | ||||
Sequence: PAFVTKLRDKECKEGDVIDFECEVEGWPEPELVWLVDDQPLRPSHDFRLQYDGQTAKLEIRDAQPDDTGVYTVKIQNEFGSIESKAELF | ||||||
Domain | 748-838 | Ig-like C2-type 3 | ||||
Sequence: PEFQATIEYVECDEGEEVRFKSVITGDPNPEIIWFINGKPLSESEKVKFISEDGICILTIKDVTRHFDGMVTCQGSNRLGSASCDGRLKVR | ||||||
Domain | 946-1033 | Ig-like C2-type 4 | ||||
Sequence: PTFLKDIEDQTVKTGEFAVFETTVRGNPNPEVTWFINGHKMDQGSPGVKIEAHNHDHKLTIDSAQYAGTVLCRAENAVGRFETKARLV | ||||||
Domain | 1044-1132 | Ig-like C2-type 5 | ||||
Sequence: PKFVEILVDKTETVDNTVVFEVRVEGEPKPTVTWYLKGEELKQSDRVEIREFDGSIKISIKNIKIEDAGEIRAVATNSEGSDETKAKLT | ||||||
Domain | 1140-1227 | Ig-like C2-type 6 | ||||
Sequence: PEFDLRPVSLTVEKGSEAVFSAHAFGIPLPTYEWSVNGRKVRDGQEGARVTRDESTVDGASILTIDTATYYSEVNHLTISVVAENTLG | ||||||
Compositional bias | 1283-1339 | Polar residues | ||||
Sequence: STKTTTMSTTEVTSTVGGVTVETKESESESATTVIGGGSGGVTEGSISVSKIEVVSK | ||||||
Region | 1283-1892 | Disordered | ||||
Sequence: STKTTTMSTTEVTSTVGGVTVETKESESESATTVIGGGSGGVTEGSISVSKIEVVSKTDSQTDVREGTPKRRVSFAEEELPKEVIDSDRKKKKSPSPDKKEKSPEKTEEKPASPTKKTGEEVKSPKEKSPASPTKKEKSPAAEEVKSPTKKEKSPSSPTKKEKSPSSPTKKTGDEVKEKSPPKSPTKKEKSPEKPEDVKSPVKKEKSPDATNIVEVSSETTIEKTETTMTTEMTHESEESRTSVKKEKTPEKVDEKPKSPTKKDKSPEKSITEEIKSPVKKEKSPEKVEEKPASPTKKEKSPEKPASPTKKSENEVKSPTKKEKSPEKSVVEELKSPKEKSPEKADDKPKSPTKKEKSPEKSATEDVKSPTKKEKSPEKVEEKPTSPTKKESSPTKKTDDEVKSPTKKEKSPQTVEEKPASPTKKEKSPEKSVVEEVKSPKEKSPEKAEEKPKSPTKKEKSPEKSAAEEVKSPTKKEKSPEKSAEEKPKSPTKKESSPVKMADDEVKSPTKKEKSPEKVEEKPASPTKKEKTPEKSAAEELKSPTKKEKSPSSPTKKTGDESKEKSPEKPEEKPKSPTPKKSPPGSPKKKKSKSPEAEKPPAPKLTRDLK | ||||||
Compositional bias | 1340-1492 | Basic and acidic residues | ||||
Sequence: TDSQTDVREGTPKRRVSFAEEELPKEVIDSDRKKKKSPSPDKKEKSPEKTEEKPASPTKKTGEEVKSPKEKSPASPTKKEKSPAAEEVKSPTKKEKSPSSPTKKEKSPSSPTKKTGDEVKEKSPPKSPTKKEKSPEKPEDVKSPVKKEKSPDA | ||||||
Domain | 1375-1475 | RCSD 1 | ||||
Sequence: KSPSPDKKEKSPEKTEEKPASPTKKTGEEVKSPKEKSPASPTKKEKSPAAEEVKSPTKKEKSPSSPTKKEKSPSSPTKKTGDEVKEKSPPKSPTKKEKSPE | ||||||
Domain | 1479-1585 | RCSD 2 | ||||
Sequence: DVKSPVKKEKSPDATNIVEVSSETTIEKTETTMTTEMTHESEESRTSVKKEKTPEKVDEKPKSPTKKDKSPEKSITEEIKSPVKKEKSPEKVEEKPASPTKKEKSPE | ||||||
Compositional bias | 1493-1510 | Polar residues | ||||
Sequence: TNIVEVSSETTIEKTETT | ||||||
Compositional bias | 1511-1860 | Basic and acidic residues | ||||
Sequence: MTTEMTHESEESRTSVKKEKTPEKVDEKPKSPTKKDKSPEKSITEEIKSPVKKEKSPEKVEEKPASPTKKEKSPEKPASPTKKSENEVKSPTKKEKSPEKSVVEELKSPKEKSPEKADDKPKSPTKKEKSPEKSATEDVKSPTKKEKSPEKVEEKPTSPTKKESSPTKKTDDEVKSPTKKEKSPQTVEEKPASPTKKEKSPEKSVVEEVKSPKEKSPEKAEEKPKSPTKKEKSPEKSAAEEVKSPTKKEKSPEKSAEEKPKSPTKKESSPVKMADDEVKSPTKKEKSPEKVEEKPASPTKKEKTPEKSAAEELKSPTKKEKSPSSPTKKTGDESKEKSPEKPEEKPKSPT | ||||||
Domain | 1597-1695 | RCSD 3 | ||||
Sequence: EVKSPTKKEKSPEKSVVEELKSPKEKSPEKADDKPKSPTKKEKSPEKSATEDVKSPTKKEKSPEKVEEKPTSPTKKESSPTKKTDDEVKSPTKKEKSPQ | ||||||
Domain | 1700-1799 | RCSD 4 | ||||
Sequence: KPASPTKKEKSPEKSVVEEVKSPKEKSPEKAEEKPKSPTKKEKSPEKSAAEEVKSPTKKEKSPEKSAEEKPKSPTKKESSPVKMADDEVKSPTKKEKSPE | ||||||
Compositional bias | 1871-1887 | Basic and acidic residues | ||||
Sequence: KKKSKSPEAEKPPAPKL | ||||||
Domain | 1982-2067 | Ig-like C2-type 7 | ||||
Sequence: PEFTDKLRDMEVTKGDTVQMDVIALHSPLYKWYQNGNLLEDGKNGVTIKNEENKSSLIIPNAQDSGKITVEASNEVGSSESSAQLT | ||||||
Domain | 2071-2163 | Ig-like C2-type 8 | ||||
Sequence: PSTTPIVVDGPKSVTIKETETAEFKATISGFPAPTVKWTINEKIVEESRTITTIKTEDVYTLKISNAKIEQTGTVKVTAQNSAGQDSKQADLK | ||||||
Domain | 2171-2261 | Ig-like C2-type 9 | ||||
Sequence: PKFKSQLTDKVADEGEPLRWNLELDGPSPGTEVSWLLNGQPLTKSDTVQVVDHGDGTYHVTIAEAKPEMSGTLTAKAKNAAGECETSAKVT | ||||||
Domain | 2269-2359 | Ig-like C2-type 10 | ||||
Sequence: PEFVQAPQNHETTLEESVKFSAIVTGKPMPNVTWYLNNKKLIQSEEVKVKYVHETGKTSIRIQKPLMEHNGTIRVEAENVSGKVQATAQLK | ||||||
Domain | 2367-2455 | Ig-like C2-type 11 | ||||
Sequence: PKFTTNMDDRQVKEGEDVKFTANVEGYPEPSVAWTLNGEPVSKHPNITVTDKDGEHTIEISAVTPEQAGELSCEATNPVGSKKRDVQLA | ||||||
Domain | 2463-2564 | Ig-like C2-type 12 | ||||
Sequence: PTFAKNLEDRLITEGELTLMDAKLNIVKPKPKITWLKDGVEITSDGHYKIVEEEDGSLKLSILQTKLEDKGRITIKAESEFGVAECSASLGVVKGRPMAKPA | ||||||
Domain | 2563-2651 | Ig-like C2-type 13 | ||||
Sequence: PAFQSDIAPINLTEGDTLECKLLITGDPTPFVKWYIGTQLVCATEDTEISNANGVYTMKIHGVTADMTGKIKCVAYNKAGEVSTEGPLK | ||||||
Domain | 2657-2746 | Ig-like C2-type 14 | ||||
Sequence: PVEFETSLCDATCREGDTLKLRAVLLGEPEPVVSWYVNGKKLEESQNIKIHSEKGTYTVTIKDITCDYSGQVVCEAINEYGKATSEATLL | ||||||
Domain | 2754-2858 | Ig-like C2-type 15 | ||||
Sequence: PDFLEWLSNVRARTGTKVVHKVVFTGDPKPSLTWYINNKEILNSDLYTIVTDDKTSTLTINSFNPDVHVGEIICKAENDAGEVSCTANMITYTSDMFSESESEAQ | ||||||
Domain | 2887-2980 | Ig-like C2-type 16 | ||||
Sequence: PKFITKIKDTKAKKGHSAVFECVVPDTKGVCCKWLKDGKEIELIARIRVQTRTGPEGHITQELVLDNVTPEDAGKYTCIVENTAGKDTCEATLT | ||||||
Domain | 2994-3081 | Ig-like C2-type 17 | ||||
Sequence: PEFIVALQDKTTKTSEKVVLECKVIGEPKPKVSWLHDNKTITQESITVESVEGVERVTITSSELSHQGKYTCIAENTEGTSKTEAFLT | ||||||
Domain | 3087-3183 | Ig-like C2-type 18 | ||||
Sequence: PVFTKELQNKELSIGEKLVLSCSVKGSPQPHVDFYSFSETTKVETKITSSSRIAIEHDQTNTHWRMVISQITKEDIVSYKAIATNSIGTATSTSKIT | ||||||
Domain | 3189-3280 | Ig-like C2-type 19 | ||||
Sequence: PVFEQGLKKTSVKEKEEIKMEVKVGGSAPDVEWFKDDKPVSEDGNHEMKKNPETGVFTLVVKQAATTDAGKYTAKASNPAGTAESSAEAEVT | ||||||
Domain | 3286-3376 | Ig-like C2-type 20 | ||||
Sequence: PTFVRELVTTEVKINETATLSVTVKGVPDPSVEWLKDGQPVQTDSSHVIAKVEGSGSYSITIKDARLEDSGKYACRATNPAGEAKTEANFA | ||||||
Domain | 3384-3469 | Ig-like C2-type 21 | ||||
Sequence: PEFVEKLSPLEVKEKESTTLSVKVVGTPEPSVEWFKDDTPISIDNVHVIQKQTAVGSFSLTINDARQGDVGIYSCRARNEAGEALT | ||||||
Domain | 3482-3572 | Ig-like C2-type 22 | ||||
Sequence: PEFTQKLRPLEVREQETLDLKVTVIGTPVPNVEWFKDDKPINIDNSHIFAKDEGSGHHTLTIKQARGEDVGVYTCKATNEAGEAKTTANMA | ||||||
Domain | 3580-3667 | Ig-like C2-type 23 | ||||
Sequence: PLFVQGLKPYEVEQGKPAELVVRVEGKPEPEVKWFKDGVPIAIDNQHVIEKKGENGSHTLVIKDTNNADFGKYTCQATNKAGKDETVG | ||||||
Domain | 3686-3777 | Ig-like C2-type 24 | ||||
Sequence: PLFIEPLKETFAVEGDTVVLECKVNKESHPQIKFFKNDQPVEIGQHMQLEVLEDGNIKLTIQNAKKEDVGAYRCEAVNVAGKANTNADLKIQ | ||||||
Domain | 3817-3908 | Ig-like C2-type 25 | ||||
Sequence: PEFVELLRSCTVTEKQQAILKCKVKGEPRPKIKWTKEGKEVEMSARVRAEHKDDGTLTLTFDNVTQADAGEYRCEAENEYGSAWTEGPIIVT | ||||||
Domain | 3920-4009 | Ig-like C2-type 26 | ||||
Sequence: PDFLQPVKPAVVTVGETAVLEGKISGKPKPSVKWYKNGEELKPSDRVKIENLDDGTQRLTVTNAKLDDMDEYRCEASNEFGDVWSDVTLT | ||||||
Domain | 4018-4106 | Ig-like C2-type 27 | ||||
Sequence: PGFFKELSAIQVKETETAKFECKVSGTKPDVKWFKDGTPLKEDKRVHFESTDDGTQRLVIEDSKTDDQGNYRIEVSNDAGVANSKVPLT | ||||||
Domain | 4109-4201 | Ig-like C2-type 28 | ||||
Sequence: PSETLKIKKGLTDVNVTQGTKILLSVEVEGKPKTVKWYKGTETVTSSQTTKIVQVTESEYKLEIESAEMSDTGAYRVVLSTDSFSVESSATVT | ||||||
Domain | 4212-4297 | Ig-like C2-type 29 | ||||
Sequence: PSFKKGLADQSVPKGTPLVLEVEIEGKPKDVKWYKNGDEIKDGKVEDLGNGKYRLTIPDFQEKDVGEYSVTAANEAGEIESKAKVN | ||||||
Domain | 4302-4387 | Ig-like C2-type 30 | ||||
Sequence: PEIVSGLVPTTVKQGETATFNVKVKGPVKGVKWYKNGKEIPDAKTKDNGDGSYSLEIPNAQVEDAADYKVVVSNDAGDADSSAALT | ||||||
Domain | 4400-4485 | Ig-like C2-type 31 | ||||
Sequence: PEIVSGLIPTTVKQGETATFNVKVKGPVKQVKWYKNGKEIPNAKAKDNGDGSYSLEIPNAQLDDTADYKVVVSNDAGDADSSAALT | ||||||
Domain | 4489-4580 | Ig-like C2-type 32 | ||||
Sequence: PGIAIVKGLEDAEVPKGKKAVLQVETNKKPKEIKWYKNGKEITPSDKAQPGSDGDNKPQLVIPDAGDDDAAEYKVVLTDEDGNTADSSCALT | ||||||
Region | 4525-4553 | Disordered | ||||
Sequence: KNGKEITPSDKAQPGSDGDNKPQLVIPDA | ||||||
Domain | 4588-4678 | Ig-like C2-type 33 | ||||
Sequence: PKIIKGLEDQVVSIGSPIKLEIETSGSPKTVKWYKNGKELPGAAAKTIKIQKIDDNKYVLEIPSSVVEDTGDYKVEVANEAGSANSSGKIT | ||||||
Domain | 4681-4771 | Ig-like C2-type 34 | ||||
Sequence: PKITFLKPLKDQSITEGENAEFSVETNTKPRIVKWYKNGQEIKPNSRFIIEQKTDTKYQLVIKNAVRDDADTYKIVLENTAGEAESSAQLT | ||||||
Domain | 4873-4961 | Ig-like C2-type 35 | ||||
Sequence: PEIVRGLENIEIPEGDDDVFKVEVSAPVRQVKWYKNDQEIKPNSHLEAKKIGPKKYELAINRAQLDDGADYKVVLSNAAGDCDSSAALT | ||||||
Domain | 4965-5057 | Ig-like C2-type 36 | ||||
Sequence: PNVLKIVDGLKDVDVEEPQPVELKVKVEGIPKVIKWYKNGQELKPDADGFKFEEKPESGEFSLTIPSSKKSDGGAYRVVLGNDKGEVYSGSVV | ||||||
Domain | 5067-5160 | Ig-like C2-type 37 | ||||
Sequence: PTSGANFLSPLKDTEVEEGDMLTLQCTIAGEPFPEVIWEKDGVVLQKDDRITMRVALDGTATLRIRSAKKSDIGQYRVTAKNEAGSATSDCKVT | ||||||
Domain | 5171-5260 | Ig-like C2-type 38 | ||||
Sequence: PKFVIPLKTGAALPGDKKEFNVKVRGLPKPTLQWFLNGIPIKFDDRITLDDMADGNYCLTIRDVREEDFGTLKCIAKNENGTDETVCEFQ | ||||||
Domain | 5277-5366 | Ig-like C2-type 39 | ||||
Sequence: PRFNVPLWDRRIPVGDPMFIECHVDANPTAEVEWFKDGKKIEHTAHTEIRNTVDGACRIKIIPFEESDIGVYMCVAVNELGQAETQATYQ | ||||||
Domain | 5383-5472 | Ig-like C2-type 40 | ||||
Sequence: PKINPPLEDKTVNGGQPIRLSCKVDAIPRASVVWYKDGLPLRADSRTSIQYEEDGTATLAINDSTEEDIGAYRCVATNAHGTINTSCSVN | ||||||
Domain | 5487-5578 | Ig-like C2-type 41 | ||||
Sequence: PFFTKGLVDLWADRGDSFTLKCAVTGDPFPEIKWYRNGQLLRNGPRTVIETSPDGSCSLTVNESTMSDEGIYRCEAENAHGKAKTQATAHVQ | ||||||
Domain | 5595-5685 | Ig-like C2-type 42 | ||||
Sequence: PKFILELSDMSVSLGNVIDLECKVTGLPNPSVKWSKDGGPLIEDSRFEWSNEASKGVYQLRIKNATVHDEGTYRCVATNENGSATTKSFVR | ||||||
Domain | 5701-5790 | Ig-like C2-type 43 | ||||
Sequence: PRFTLKMGDVRTTEGQPLKLECKVDASPLPEMVWYKDGAIVTPSDRIQISLSPDGVATLLIPSCVYDDDGIYRVIATNPSGTAQDKGTAT | ||||||
Domain | 5815-5904 | Ig-like C2-type 44 | ||||
Sequence: PKLMEPLENIRIPEKQSFRLRCKFSGDPKPTIKWFKDGERVFPYGRLQLIESPDGVCELVVDSATRQDAGGYRCVAENTYGSARTSCDVN | ||||||
Domain | 5925-6014 | Ig-like C2-type 45 | ||||
Sequence: PGFTTPLTIRRAKPGDSVTFECLPFGNPFPSIKWLKDGLELFSDEKIKMEAAADGTQRLILSDVTFLSEGYFRCVATNEHGTASTKAELV | ||||||
Domain | 6038-6130 | Ig-like C2-type 46 | ||||
Sequence: PRIRRGLYNMSIHEGNVVEMIVCATGIPTPTVKWYKDGQEIVGDGPDGKRVIFTDERGIHHLVIVNASPDDEGEYSLEATNKLGSAKTEGSLN | ||||||
Domain | 6150-6239 | Ig-like C2-type 47 | ||||
Sequence: PGFVRQLKNKHVFNHMPTIFDCLVVGHPAPEVEWFHNGKKIVPGGRIKIQSCGGGSHALIILDTTLEDAGEYVATAKNSHGSASSSAVLD | ||||||
Domain | 6278-6374 | Fibronectin type-III 1 | ||||
Sequence: PDRGPFIKEVTGHYLTLSWIPTKRAPPRYPQVTYVIEIRELPEKQWSLLEYNIPEPVCKVRNLELGKSYQFRVRAENIYGISDPSPASPPSRLMAPP | ||||||
Domain | 6413-6502 | Ig-like C2-type 48 | ||||
Sequence: PGVVEKRYCAENDTLTIVLNVSGFPDPDIKWKFRGWDIDTSSPTSKCKVYTYGGSETTLAITGFSKENVGQYQCFAKNDYGDAQQNIMVD | ||||||
Domain | 6507-6596 | Ig-like C2-type 49 | ||||
Sequence: PNFIQPLVNKTFSSAQPMRMDVRVDGEPFPELKWMKEWRPIVESSRIKFVQDGPYLCSLIINDPMWRDSGIYSCVAVNDAGQATTSCTVT | ||||||
Domain | 6592-6878 | Protein kinase 1 | ||||
Sequence: SCTVTVEAEGDYNDVELPRRRVTIESRRVRELYEISEKDEKLAAEGAPFRVKEKATGREFLAQLRPIDDALMRHVDIHNSLDHPGIVQMHRVLRDEKLALVVFDNANSTIDGLSSLAHPGVEIAEPKGVNRETCVRVFVRQLLLALKHMHDLRIAHLDLRPETILLQDDKLKLADFGQARRLLRGLITGEIKGSPEFVSPEIVRSYPLTLATDMWSTGVLTYVLLTGLSPFHGDNDNETLANVDSCQFDSSPLGNFSYDAGDFVKKLLTEIPVSRLTVDEALDHPWI | ||||||
Region | 6954-7130 | Disordered | ||||
Sequence: KKPPPTVEYVPQPRKEHPPFIDEFGQLIDGDAFDRPEGTGFEGPHRQPPQIPPQPQRPNQAAHDSRRHEQQPQHQGQPQRIPVDQYGRPLVDPRYLNDPSHRPSSLDDAPFYVDKYGNPVHFDKYGRPMAPQNLEKRKLIPQDKGETPSHSKKEKTQHPVATPILASPGGDQQQQKI | ||||||
Compositional bias | 7090-7110 | Basic and acidic residues | ||||
Sequence: RKLIPQDKGETPSHSKKEKTQ | ||||||
Region | 7177-7217 | Disordered | ||||
Sequence: QVEASEPSTPTLTPEVTIRETIPKPTPSPTSPQKSPVPQPQ | ||||||
Compositional bias | 7284-7309 | Polar residues | ||||
Sequence: PAINLSPNPKSPRRSTPGTKSPVVLS | ||||||
Region | 7284-7311 | Disordered | ||||
Sequence: PAINLSPNPKSPRRSTPGTKSPVVLSPR | ||||||
Region | 7324-7343 | Disordered | ||||
Sequence: RGKPGFLPPGELAEDIDDED | ||||||
Region | 7348-7372 | Disordered | ||||
Sequence: DRKKQVKPKDHDGENDFKDEKERLE | ||||||
Domain | 7528-7617 | Ig-like C2-type 50 | ||||
Sequence: PIFTARLRDVYLRKNQPAIFECAVSASPAPKVTWDFQGKILESNDRVTIEQDNNVARLILNHAAPYDLGEYVCTAINEYGTDKSSCRLIS | ||||||
Domain | 7623-7721 | Fibronectin type-III 2 | ||||
Sequence: RPGRPEAELSSDTEIFIQWEAPEGPTYLEGITYRLEYRVAGPNDHGDPWITVSEKIDDESVIVKHLSPLGIYQFRVTAQNGFGLGLPSLSSRIVQTHGK | ||||||
Region | 7746-7773 | Disordered | ||||
Sequence: STNQLGGISEESEEDSEARTANEDMKSN | ||||||
Domain | 7785-8035 | Protein kinase 2 | ||||
Sequence: FQIGGLKFKGRFSVIRDAVDSTTEGHAHCAVKIRHPSSEAISEYESLRDGQHENVQRLIAAFNNSNFLYLLSERLYEDVFSRFVFNDYYTEEQVALTMRQVTSALHFLHFKGIAHLDVNPHNIMFQSKRSWVVKLVDFGRAQKVSGAVKPVDFDTKWASPEFHIPETPVTVQSDMWGMGVVTFCLLAGFHPFTSEYDREEEIKENVINVKCDPNLIPVNASQECLSFATWALKKSPVRRMRTDEALSHKFL |
Domain
Protein kinase domains 1 and 2 are predicted to be catalytically inactive (PubMed:16453163).
The two kinase domains are required for the organization of thick filament component myosin heavy chain myo-3 but not of myosin heavy chain unc-54 and unc-15/paramyosin (PubMed:27009202).
The two kinase domains are required for the organization of thick filament component myosin heavy chain myo-3 but not of myosin heavy chain unc-54 and unc-15/paramyosin (PubMed:27009202).
The SH3 domain is required for the organization of thick filament components myosin heavy chain unc-54 and myo-3 and unc-15/paramyosin.
The PH domain does not bind inositol 1,4,5-trisphosphate. The PH domain has an unusual closed conformation of the lipid binding site which is lined by negative charged amino acids which probably prevents binding to membrane lipids.
Sequence similarities
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 7 isoforms produced by Alternative splicing.
O01761-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Nameb
- Length8,081
- Mass (Da)894,252
- Last updated2005-09-13 v3
- Checksum67C804953CF62228
O01761-2
- Namea
- Differences from canonical
- 6633-8081: Missing
O01761-3
- Namec
- Differences from canonical
- 1-6688: Missing
- 6689-6696: LALVVFDN → MVRFTINC
O01761-4
- Named
- Differences from canonical
- 1-6685: Missing
- 6686-6696: DEKLALVVFDN → MFRLVEDCELC
O01761-5
- Namee
- Differences from canonical
- 1241-1880: Missing
- 6633-8081: Missing
O01761-6
- Namef
- Differences from canonical
- 1241-1880: Missing
O01761-7
- Nameg
- Differences from canonical
- 6632-6695: Missing
- 7175-7186: DFQVEASEPSTP → VTEGDGCNMCGE
- 7187-8081: Missing
Computationally mapped potential isoform sequences
There are 9 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2C9C3B7 | A0A2C9C3B7_CAEEL | unc-89 | 7361 | ||
A0A2C9C330 | A0A2C9C330_CAEEL | unc-89 | 6610 | ||
A0A2C9C332 | A0A2C9C332_CAEEL | unc-89 | 6968 | ||
A0A2C9C2S8 | A0A2C9C2S8_CAEEL | unc-89 | 8059 | ||
A0A2C9C2V3 | A0A2C9C2V3_CAEEL | unc-89 | 7035 | ||
A0A2C9C2V5 | A0A2C9C2V5_CAEEL | unc-89 | 7586 | ||
A0A2C9C365 | A0A2C9C365_CAEEL | unc-89 | 5912 | ||
A0A2C9C2W9 | A0A2C9C2W9_CAEEL | unc-89 | 7508 | ||
A0A2C9C2G8 | A0A2C9C2G8_CAEEL | unc-89 | 6888 |
Features
Showing features for alternative sequence, compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_015542 | 1-6685 | in isoform d | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_015541 | 1-6688 | in isoform c | |||
Sequence: Missing | ||||||
Compositional bias | 479-494 | Polar residues | ||||
Sequence: ASDQQSEFSEWSGSRK | ||||||
Compositional bias | 516-531 | Polar residues | ||||
Sequence: VISPTGSSTSIYSGGS | ||||||
Alternative sequence | VSP_015543 | 1241-1880 | in isoform e and isoform f | |||
Sequence: Missing | ||||||
Compositional bias | 1283-1339 | Polar residues | ||||
Sequence: STKTTTMSTTEVTSTVGGVTVETKESESESATTVIGGGSGGVTEGSISVSKIEVVSK | ||||||
Compositional bias | 1340-1492 | Basic and acidic residues | ||||
Sequence: TDSQTDVREGTPKRRVSFAEEELPKEVIDSDRKKKKSPSPDKKEKSPEKTEEKPASPTKKTGEEVKSPKEKSPASPTKKEKSPAAEEVKSPTKKEKSPSSPTKKEKSPSSPTKKTGDEVKEKSPPKSPTKKEKSPEKPEDVKSPVKKEKSPDA | ||||||
Compositional bias | 1493-1510 | Polar residues | ||||
Sequence: TNIVEVSSETTIEKTETT | ||||||
Compositional bias | 1511-1860 | Basic and acidic residues | ||||
Sequence: MTTEMTHESEESRTSVKKEKTPEKVDEKPKSPTKKDKSPEKSITEEIKSPVKKEKSPEKVEEKPASPTKKEKSPEKPASPTKKSENEVKSPTKKEKSPEKSVVEELKSPKEKSPEKADDKPKSPTKKEKSPEKSATEDVKSPTKKEKSPEKVEEKPTSPTKKESSPTKKTDDEVKSPTKKEKSPQTVEEKPASPTKKEKSPEKSVVEEVKSPKEKSPEKAEEKPKSPTKKEKSPEKSAAEEVKSPTKKEKSPEKSAEEKPKSPTKKESSPVKMADDEVKSPTKKEKSPEKVEEKPASPTKKEKTPEKSAAEELKSPTKKEKSPSSPTKKTGDESKEKSPEKPEEKPKSPT | ||||||
Compositional bias | 1871-1887 | Basic and acidic residues | ||||
Sequence: KKKSKSPEAEKPPAPKL | ||||||
Sequence conflict | 2137 | in Ref. 1; AAB00542 | ||||
Sequence: A → P | ||||||
Sequence conflict | 2245-2247 | in Ref. 1; AAB00542 | ||||
Sequence: AKA → PKP | ||||||
Sequence conflict | 2258 | in Ref. 1; AAB00542 | ||||
Sequence: A → P | ||||||
Sequence conflict | 2284 | in Ref. 1; AAB00542 | ||||
Sequence: E → G | ||||||
Sequence conflict | 2297 | in Ref. 1; AAB00542 | ||||
Sequence: M → I | ||||||
Sequence conflict | 3531 | in Ref. 1; AAB00542 | ||||
Sequence: A → G | ||||||
Sequence conflict | 3884-3888 | in Ref. 1; AAB00542 | ||||
Sequence: DAGEY → RRRRI | ||||||
Sequence conflict | 3929 | in Ref. 1; AAB00542 | ||||
Sequence: A → V | ||||||
Sequence conflict | 5134 | in Ref. 1; AAB00542 | ||||
Sequence: A → P | ||||||
Sequence conflict | 5145 | in Ref. 1; AAB00542 | ||||
Sequence: T → S | ||||||
Sequence conflict | 5185 | in Ref. 1; AAB00542 | ||||
Sequence: G → A | ||||||
Sequence conflict | 5199 | in Ref. 1; AAB00542 | ||||
Sequence: K → N | ||||||
Sequence conflict | 5202 | in Ref. 1; AAB00542 | ||||
Sequence: L → F | ||||||
Sequence conflict | 5213 | in Ref. 1; AAB00542 | ||||
Sequence: F → L | ||||||
Sequence conflict | 6178 | in Ref. 1; AAB00542 | ||||
Sequence: A → G | ||||||
Sequence conflict | 6268 | in Ref. 1; AAB00542 | ||||
Sequence: K → E | ||||||
Alternative sequence | VSP_015544 | 6632-6695 | in isoform g | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_015545 | 6633-8081 | in isoform a and isoform e | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_015546 | 6686-6696 | in isoform d | |||
Sequence: DEKLALVVFDN → MFRLVEDCELC | ||||||
Alternative sequence | VSP_015547 | 6689-6696 | in isoform c | |||
Sequence: LALVVFDN → MVRFTINC | ||||||
Compositional bias | 7090-7110 | Basic and acidic residues | ||||
Sequence: RKLIPQDKGETPSHSKKEKTQ | ||||||
Alternative sequence | VSP_015548 | 7175-7186 | in isoform g | |||
Sequence: DFQVEASEPSTP → VTEGDGCNMCGE | ||||||
Alternative sequence | VSP_015549 | 7187-8081 | in isoform g | |||
Sequence: Missing | ||||||
Compositional bias | 7284-7309 | Polar residues | ||||
Sequence: PAINLSPNPKSPRRSTPGTKSPVVLS |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U33058 EMBL· GenBank· DDBJ | AAB00542.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FO080458 EMBL· GenBank· DDBJ | CCD63864.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FO080458 EMBL· GenBank· DDBJ | CCD63865.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FO080458 EMBL· GenBank· DDBJ | CCD63866.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FO080458 EMBL· GenBank· DDBJ | CCD63867.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FO080458 EMBL· GenBank· DDBJ | CCD63868.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FO080458 EMBL· GenBank· DDBJ | CCD63869.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FO080458 EMBL· GenBank· DDBJ | CCD63870.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY724774 EMBL· GenBank· DDBJ | AAU21474.1 EMBL· GenBank· DDBJ | mRNA | ||
AY714779 EMBL· GenBank· DDBJ | AAU14146.1 EMBL· GenBank· DDBJ | mRNA |