O00939 · TERT_EUPAE

Function

function

Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.

Catalytic activity

Features

Showing features for binding site.

110311002003004005006007008009001,000
TypeIDPosition(s)Description
Binding site603Mg2+ (UniProtKB | ChEBI); catalytic
Binding site781Mg2+ (UniProtKB | ChEBI); catalytic
Binding site782Mg2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentchromosome, telomeric region
Cellular Componenttelomerase catalytic core complex
Molecular Functionmetal ion binding
Molecular FunctionRNA-directed DNA polymerase activity
Molecular Functiontelomerase RNA binding
Molecular Functiontelomeric DNA binding
Biological Processtelomere maintenance via telomerase

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Telomerase reverse transcriptase
  • EC number
  • Alternative names
    • Telomerase catalytic subunit
    • Telomerase subunit P123

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Ciliophora > Intramacronucleata > Spirotrichea > Hypotrichia > Euplotida > Euplotidae > Euplotes

Accessions

  • Primary accession
    O00939

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000549271-1031Telomerase reverse transcriptase

Interaction

Subunit

Component of the telomerase holoenzyme complex composed minimally of the catalytic subunit p123 and the telomerase RNA template component.

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain498-852Reverse transcriptase

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,031
  • Mass (Da)
    122,563
  • Last updated
    1997-07-01 v1
  • Checksum
    57B87A63A1FED60F
MEVDVDNQADNHGIHSALKTCEEIKEAKTLYSWIQKVIRCRNQSQSHYKDLEDIKIFAQTNIVATPRDYNEEDFKVIARKEVFSTGLMIELIDKCLVELLSSSDVSDRQKLQCFGFQLKGNQLAKTHLLTALSTQKQYFFQDEWNQVRAMIGNELFRHLYTKYLIFQRTSEGTLVQFCGNNVFDHLKVNDKFDKKQKGGAADMNEPRCCSTCKYNVKNEKDHFLNNINVPNWNNMKSRTRIFYCTHFNRNNQFFKKHEFVSNKNNISAMDRAQTIFTNIFRFNRIRKKLKDKVIEKIAYMLEKVKDFNFNYYLTKSCPLPENWRERKQKIENLINKTREEKSKYYEELFSYTTDNKCVTQFINEFFYNILPKDFLTGRNRKNFQKKVKKYVELNKHELIHKNLLLEKINTREISWMQVETSAKHFYYFDHENIYVLWKLLRWIFEDLVVSLIRCFFYVTEQQKSYSKTYYYRKNIWDVIMKMSIADLKKETLAEVQEKEVEEWKKSLGFAPGKLRLIPKKTTFRPIMTFNKKIVNSDRKTTKLTTNTKLLNSHLMLKTLKNRMFKDPFGFAVFNYDDVMKKYEEFVCKWKQVGQPKLFFATMDIEKCYDSVNREKLSTFLKTTKLLSSDFWIMTAQILKRKNNIVIDSKNFRKKEMKDYFRQKFQKIALEGGQYPTLFSVLENEQNDLNAKKTLIVEAKQRNYFKKDNLLQPVINICQYNYINFNGKFYKQTKGIPQGLCVSSILSSFYYATLEESSLGFLRDESMNPENPNVNLLMRLTDDYLLITTQENNAVLFIEKLINVSRENGFKFNMKKLQTSFPLSPSKFAKYGMDSVEEQNIVQDYCDWIGISIDMKTLALMPNINLRIEGILCTLNLNMQTKKASMWLKKKLKSFLMNNITHYFRKTITTEDFANKTLNKLFISGGYKYMQCAKEYKDHFKKNLAMSSMIDLEVSKIIYSVTRAFFKYLVCNIKDTIFGEEHYPDFFLSTLKHFIEIFSTKKYIFNRVCMILKAKEAKLKSDQCQSLIQYDA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U95964
EMBL· GenBank· DDBJ
AAC47515.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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