O00445 · SYT5_HUMAN
- ProteinSynaptotagmin-5
- GeneSYT5
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids386 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Cofactor
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 138 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: L | ||||||
Binding site | 139 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 139 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 145 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 197 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 197 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 198 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: F | ||||||
Binding site | 199 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 199 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 199 | Ca2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 202 | Ca2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 205 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 205 | Ca2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 270 | Ca2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 276 | Ca2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 330 | Ca2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 332 | Ca2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | axon | |
Cellular Component | dense core granule | |
Cellular Component | exocytic vesicle | |
Cellular Component | neuronal cell body | |
Cellular Component | neuronal dense core vesicle membrane | |
Cellular Component | perinuclear region of cytoplasm | |
Cellular Component | plasma membrane | |
Cellular Component | proximal neuron projection | |
Cellular Component | recycling endosome membrane | |
Cellular Component | synaptic vesicle membrane | |
Molecular Function | calcium ion binding | |
Molecular Function | calcium-dependent phospholipid binding | |
Molecular Function | clathrin binding | |
Molecular Function | phosphatidylinositol-4,5-bisphosphate binding | |
Molecular Function | phosphatidylserine binding | |
Molecular Function | protein heterodimerization activity | |
Molecular Function | SNARE binding | |
Molecular Function | syntaxin binding | |
Biological Process | calcium ion-regulated exocytosis of neurotransmitter | |
Biological Process | chemical synaptic transmission | |
Biological Process | regulation of calcium ion-dependent exocytosis | |
Biological Process | synaptic vesicle endocytosis |
Keywords
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSynaptotagmin-5
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionO00445
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-24 | Vesicular | ||||
Sequence: MFPEPPTPGPPSPDTPPDSSRISH | ||||||
Transmembrane | 25-45 | Helical | ||||
Sequence: GPVPPWALATIVLVSGLLIFS | ||||||
Topological domain | 46-386 | Cytoplasmic | ||||
Sequence: CCFCLYRKSCRRRTGKKSQAQAQVHLQEVKGLGQSYIDKVQPEVEELEPAPSGPGQQVADKHELGRLQYSLDYDFQSGQLLVGILQAMGLAALDLGGSSDPYVRVYLLPDKRRRYETKVHRQTLNPHFGETFAFKVPYVELGGRVLVMAVYDFDRFSRNDAIGEVRVPMSSVDLGRPVQAWRELQAAPREEQEKLGDICFSLRYVPTAGKLTVIVLEAKNLKKMDVGGLSDPYVKVHLLQGGKKVRKKKTTIKKNTLNPYYNEAFSFEVPCDQVQKVQVELTVLDYDKLGKNEAIGRVAVGAAAGGAGLRHWADMLANPRRPIAQWHSLRPPDRVRLLPAP |
Keywords
- Cellular component
Disease & Variants
Features
Showing features for natural variant, mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_052240 | 4 | in dbSNP:rs2301279 | |||
Sequence: E → D | ||||||
Natural variant | VAR_034528 | 111 | in dbSNP:rs11542503 | |||
Sequence: R → Q | ||||||
Mutagenesis | 202 | Does not affect Ca2+ affinity as measured by isothermal titration calorimetry of the mutant protein. | ||||
Sequence: S → G |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 518 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000183951 | 1-386 | Synaptotagmin-5 | |||
Sequence: MFPEPPTPGPPSPDTPPDSSRISHGPVPPWALATIVLVSGLLIFSCCFCLYRKSCRRRTGKKSQAQAQVHLQEVKGLGQSYIDKVQPEVEELEPAPSGPGQQVADKHELGRLQYSLDYDFQSGQLLVGILQAMGLAALDLGGSSDPYVRVYLLPDKRRRYETKVHRQTLNPHFGETFAFKVPYVELGGRVLVMAVYDFDRFSRNDAIGEVRVPMSSVDLGRPVQAWRELQAAPREEQEKLGDICFSLRYVPTAGKLTVIVLEAKNLKKMDVGGLSDPYVKVHLLQGGKKVRKKKTTIKKNTLNPYYNEAFSFEVPCDQVQKVQVELTVLDYDKLGKNEAIGRVAVGAAAGGAGLRHWADMLANPRRPIAQWHSLRPPDRVRLLPAP |
Proteomic databases
PTM databases
Expression
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-17 | Pro residues | ||||
Sequence: MFPEPPTPGPPSPDTPP | ||||||
Region | 1-23 | Disordered | ||||
Sequence: MFPEPPTPGPPSPDTPPDSSRIS | ||||||
Domain | 108-227 | C2 1 | ||||
Sequence: ELGRLQYSLDYDFQSGQLLVGILQAMGLAALDLGGSSDPYVRVYLLPDKRRRYETKVHRQTLNPHFGETFAFKVPYVELGGRVLVMAVYDFDRFSRNDAIGEVRVPMSSVDLGRPVQAWR | ||||||
Domain | 239-372 | C2 2 | ||||
Sequence: KLGDICFSLRYVPTAGKLTVIVLEAKNLKKMDVGGLSDPYVKVHLLQGGKKVRKKKTTIKKNTLNPYYNEAFSFEVPCDQVQKVQVELTVLDYDKLGKNEAIGRVAVGAAAGGAGLRHWADMLANPRRPIAQWH |
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
O00445-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length386
- Mass (Da)42,900
- Last updated2003-07-11 v2
- Checksum96A36792D177FD55
O00445-2
- Name2
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Features
Showing features for compositional bias, alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-17 | Pro residues | ||||
Sequence: MFPEPPTPGPPSPDTPP | ||||||
Alternative sequence | VSP_057177 | 1-84 | in isoform 2 | |||
Sequence: MFPEPPTPGPPSPDTPPDSSRISHGPVPPWALATIVLVSGLLIFSCCFCLYRKSCRRRTGKKSQAQAQVHLQEVKGLGQSYIDK → MTRGGCPVSARLFAQRPHGSWSSLLCVGLKGRLGWEWGTRVLECLCRKDSRTPPPCSRSPQPRGLHRPTRLPTPVASATAQ | ||||||
Sequence conflict | 24 | in Ref. 2; BAG54160 | ||||
Sequence: H → R | ||||||
Alternative sequence | VSP_057178 | 237 | in isoform 2 | |||
Sequence: Missing |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X96783 EMBL· GenBank· DDBJ | CAA65579.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AK125182 EMBL· GenBank· DDBJ | BAG54160.1 EMBL· GenBank· DDBJ | mRNA | ||
AK295337 EMBL· GenBank· DDBJ | BAH12036.1 EMBL· GenBank· DDBJ | mRNA | ||
AC010327 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC046157 EMBL· GenBank· DDBJ | AAH46157.1 EMBL· GenBank· DDBJ | mRNA |