O00442 · RTCA_HUMAN

  • Protein
    RNA 3'-terminal phosphate cyclase
  • Gene
    RTCA
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA (PubMed:9184239).
The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product (PubMed:9184239).
Likely functions in some aspects of cellular RNA processing (PubMed:25961792, PubMed:9184239).
Function plays an important role in regulating axon regeneration by inhibiting central nervous system (CNS) axon regeneration following optic nerve injury (PubMed:25961792).

Features

Showing features for binding site, active site.

136650100150200250300350
TypeIDPosition(s)Description
Binding site104ATP (UniProtKB | ChEBI)
Binding site131ATP (UniProtKB | ChEBI)
Binding site294ATP (UniProtKB | ChEBI)
Binding site297ATP (UniProtKB | ChEBI)
Binding site298ATP (UniProtKB | ChEBI)
Active site320Tele-AMP-histidine intermediate
Binding site320ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentnucleoplasm
Cellular Componentnucleus
Molecular FunctionATP binding
Molecular FunctionRNA binding
Molecular FunctionRNA-3'-phosphate cyclase activity
Biological Processnegative regulation of optical nerve axon regeneration
Biological ProcessRNA processing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    RNA 3'-terminal phosphate cyclase
  • EC number
  • Short names
    RNA cyclase; RNA-3'-phosphate cyclase
  • Alternative names
    • RNA terminal phosphate cyclase domain-containing protein 1 (RTC domain-containing protein 1)

Gene names

    • Name
      RTCA
    • Synonyms
      RPC, RPC1, RTC1, RTCD1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    O00442
  • Secondary accessions
    • Q5VVL5
    • Q5VVL6
    • Q96E99

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 460 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
ChainPRO_00001564101-366UniProtRNA 3'-terminal phosphate cyclase
Modified residue (large scale data)173PRIDEPhosphoserine
Modified residue (large scale data)314PRIDEPhosphothreonine

Proteomic databases

PTM databases

Expression

Tissue specificity

Ubiquitous.

Gene expression databases

Organism-specific databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY O00442-2OTX2 P32243-23EBI-12886464, EBI-9087860

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

O00442-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    366
  • Mass (Da)
    39,337
  • Last updated
    1997-07-01 v1
  • Checksum
    D129E680FF08BAD1
MAGPRVEVDGSIMEGGGQILRVSTALSCLLGLPLRVQKIRAGRSTPGLRPQHLSGLEMIRDLCDGQLEGAEIGSTEITFTPEKIKGGIHTADTKTAGSVCLLMQVSMPCVLFAASPSELHLKGGTNAEMAPQIDYTVMVFKPIVEKFGFIFNCDIKTRGYYPKGGGEVIVRMSPVKQLNPINLTERGCVTKIYGRAFVAGVLPFKVAKDMAAAAVRCIRKEIRDLYVNIQPVQEPKDQAFGNGNGIIIIAETSTGCLFAGSSLGKRGVNADKVGIEAAEMLLANLRHGGTVDEYLQDQLIVFMALANGVSRIKTGPVTLHTQTAIHFAEQIAKAKFIVKKSEDEEDAAKDTYIIECQGIGMTNPNL

O00442-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 48-48: L → LSSGGWKSKIKVLT

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A6NIC1A6NIC1_HUMANRTCA49

Features

Showing features for sequence conflict, alternative sequence.

TypeIDPosition(s)Description
Sequence conflict34in Ref. 4; AAH12604
Alternative sequenceVSP_00591548in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
Y11651
EMBL· GenBank· DDBJ
CAA72364.1
EMBL· GenBank· DDBJ
mRNA
Y11652
EMBL· GenBank· DDBJ
CAA72365.1
EMBL· GenBank· DDBJ
Genomic DNA
AL445928
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL663111
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471097
EMBL· GenBank· DDBJ
EAW72961.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471097
EMBL· GenBank· DDBJ
EAW72962.1
EMBL· GenBank· DDBJ
Genomic DNA
BC012604
EMBL· GenBank· DDBJ
AAH12604.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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