O00400 · ACATN_HUMAN
- ProteinAcetyl-coenzyme A transporter 1
- GeneSLC33A1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids549 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Acetyl-CoA transporter that mediates active acetyl-CoA import through the endoplasmic reticulum (ER) membrane into the ER lumen where specific ER-based acetyl-CoA:lysine acetyltransferases are responsible for the acetylation of ER-based protein substrates, such as BACE1 (PubMed:20826464, PubMed:24828632).
Necessary for O-acetylation of gangliosides (PubMed:9096318).
Necessary for O-acetylation of gangliosides (PubMed:9096318).
Catalytic activity
- acetyl-CoA(in) = acetyl-CoA(out)This reaction proceeds in the forward direction.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | Golgi membrane | |
Cellular Component | membrane | |
Cellular Component | plasma membrane | |
Molecular Function | acetyl-CoA transmembrane transporter activity | |
Molecular Function | protein homodimerization activity | |
Biological Process | acetyl-CoA transmembrane transport | |
Biological Process | transmembrane transport |
Keywords
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameAcetyl-coenzyme A transporter 1
- Short namesAT-1 ; Acetyl-CoA transporter 1
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionO00400
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-74 | Cytoplasmic | ||||
Sequence: MSPTISHKDSSRQRRPGNFSHSLDMKSGPLPPGGWDDSHLDSAGREGDREALLGDTGTGDFLKAPQSFRAELSS | ||||||
Transmembrane | 75-95 | Helical | ||||
Sequence: ILLLLFLYVLQGIPLGLAGSI | ||||||
Topological domain | 96-113 | Extracellular | ||||
Sequence: PLILQSKNVSYTDQAFFS | ||||||
Transmembrane | 114-134 | Helical | ||||
Sequence: FVFWPFSLKLLWAPLVDAVYV | ||||||
Topological domain | 135-141 | Cytoplasmic | ||||
Sequence: KNFGRRK | ||||||
Transmembrane | 142-162 | Helical | ||||
Sequence: SWLVPTQYILGLFMIYLSTQV | ||||||
Topological domain | 163-175 | Extracellular | ||||
Sequence: DRLLGNTDDRTPD | ||||||
Transmembrane | 176-196 | Helical | ||||
Sequence: VIALTVAFFLFEFLAATQDIA | ||||||
Topological domain | 197-217 | Cytoplasmic | ||||
Sequence: VDGWALTMLSRENVGYASTCN | ||||||
Transmembrane | 218-238 | Helical | ||||
Sequence: SVGQTAGYFLGNVLFLALESA | ||||||
Topological domain | 239-256 | Extracellular | ||||
Sequence: DFCNKYLRFQPQPRGIVT | ||||||
Transmembrane | 257-277 | Helical | ||||
Sequence: LSDFLFFWGTVFLITTTLVAL | ||||||
Topological domain | 278-299 | Cytoplasmic | ||||
Sequence: LKKENEVSVVKEETQGITDTYK | ||||||
Transmembrane | 300-320 | Helical | ||||
Sequence: LLFAIIKMPAVLTFCLLILTA | ||||||
Topological domain | 321-343 | Extracellular | ||||
Sequence: KIGFSAADAVTGLKLVEEGVPKE | ||||||
Transmembrane | 344-364 | Helical | ||||
Sequence: HLALLAVPMVPLQIILPLIIS | ||||||
Topological domain | 365-378 | Cytoplasmic | ||||
Sequence: KYTAGPQPLNTFYK | ||||||
Transmembrane | 379-398 | Helical | ||||
Sequence: AMPYRLLLGLEYALLVWWTP | ||||||
Topological domain | 399-404 | Extracellular | ||||
Sequence: KVEHQG | ||||||
Transmembrane | 405-425 | Helical | ||||
Sequence: GFPIYYYIVVLLSYALHQVTV | ||||||
Topological domain | 426-508 | Cytoplasmic | ||||
Sequence: YSMYVSIMAFNAKVSDPLIGGTYMTLLNTVSNLGGNWPSTVALWLVDPLTVKECVGASNQNCRTPDAVELCKKLGGSCVTALD | ||||||
Transmembrane | 509-529 | Helical | ||||
Sequence: GYYVESIICVFIGFGWWFFLG | ||||||
Topological domain | 530-549 | Extracellular | ||||
Sequence: PKFKKLQDEGSSSWKCKRNN |
Keywords
- Cellular component
Disease & Variants
Involvement in disease
Spastic paraplegia 42, autosomal dominant (SPG42)
- Note
- DescriptionA form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body.
- See alsoMIM:612539
Natural variants in SPG42
Variant ID | Position(s) | Change | Description | |
---|---|---|---|---|
VAR_054850 | 113 | S>R | in SPG42; significant increase in the amount of nuclear phosphorylated SMAD1-SMAD5-SMAD8 protein complex; marked increase of the BMPR1A protein level; no change for BMPR2 protein level; decrease of BMPR1A degradation; Loss of homodimerization in the endoplasmic membrane; loss of acetyl-CoA transport activity; dbSNP:rs121909484 |
Huppke-Brendel syndrome (HPBDS)
- Note
- DescriptionAn autosomal recessive disorder characterized by congenital cataracts, severe psychomotor retardation, and hearing loss associated with decreased serum ceruloplasmin and copper. Brain MRI shows cerebral and cerebellar atrophy and hypomyelination.
- See alsoMIM:614482
Natural variants in HPBDS
Variant ID | Position(s) | Change | Description | |
---|---|---|---|---|
VAR_067915 | 110 | A>P | in HPBDS; the mutant protein is present at normal levels in patient fibroblasts; the mutant protein fails to localize normally to the Golgi apparatus and instead shows punctate staining in the cytoplasm; dbSNP:rs281875283 |
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_067915 | 110 | in HPBDS; the mutant protein is present at normal levels in patient fibroblasts; the mutant protein fails to localize normally to the Golgi apparatus and instead shows punctate staining in the cytoplasm; dbSNP:rs281875283 | |||
Sequence: A → P | ||||||
Natural variant | VAR_054850 | 113 | in SPG42; significant increase in the amount of nuclear phosphorylated SMAD1-SMAD5-SMAD8 protein complex; marked increase of the BMPR1A protein level; no change for BMPR2 protein level; decrease of BMPR1A degradation; Loss of homodimerization in the endoplasmic membrane; loss of acetyl-CoA transport activity; dbSNP:rs121909484 | |||
Sequence: S → R | ||||||
Natural variant | VAR_050631 | 171 | in dbSNP:rs3804769 | |||
Sequence: D → G | ||||||
Natural variant | VAR_035776 | 400 | in a colorectal cancer sample; somatic mutation | |||
Sequence: V → A |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 574 variants from UniProt as well as other sources including ClinVar and dbSNP.
Keywords
- Disease
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue (large scale data), modified residue, glycosylation.
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000076165 | 1-549 | UniProt | Acetyl-coenzyme A transporter 1 | |||
Sequence: MSPTISHKDSSRQRRPGNFSHSLDMKSGPLPPGGWDDSHLDSAGREGDREALLGDTGTGDFLKAPQSFRAELSSILLLLFLYVLQGIPLGLAGSIPLILQSKNVSYTDQAFFSFVFWPFSLKLLWAPLVDAVYVKNFGRRKSWLVPTQYILGLFMIYLSTQVDRLLGNTDDRTPDVIALTVAFFLFEFLAATQDIAVDGWALTMLSRENVGYASTCNSVGQTAGYFLGNVLFLALESADFCNKYLRFQPQPRGIVTLSDFLFFWGTVFLITTTLVALLKKENEVSVVKEETQGITDTYKLLFAIIKMPAVLTFCLLILTAKIGFSAADAVTGLKLVEEGVPKEHLALLAVPMVPLQIILPLIISKYTAGPQPLNTFYKAMPYRLLLGLEYALLVWWTPKVEHQGGFPIYYYIVVLLSYALHQVTVYSMYVSIMAFNAKVSDPLIGGTYMTLLNTVSNLGGNWPSTVALWLVDPLTVKECVGASNQNCRTPDAVELCKKLGGSCVTALDGYYVESIICVFIGFGWWFFLGPKFKKLQDEGSSSWKCKRNN | |||||||
Modified residue (large scale data) | 2 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 22 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 22 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 42 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Glycosylation | 103 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Ubiquitous. Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. With strongest signals in pancreas.
Induction
Expression is induced in presence of ceramide.
Gene expression databases
Organism-specific databases
Interaction
Subunit
Homodimerizes.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | O00400 | CFTR P13569 | 6 | EBI-11135403, EBI-349854 |
Protein-protein interaction databases
Chemistry
Miscellaneous
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-46 | Disordered | ||||
Sequence: MSPTISHKDSSRQRRPGNFSHSLDMKSGPLPPGGWDDSHLDSAGRE |
Sequence similarities
Belongs to the SLC33A transporter family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length549
- Mass (Da)60,909
- Last updated1997-07-01 v1
- ChecksumABDE59DEDEBAA9A5
Computationally mapped potential isoform sequences
There are 7 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2R8Y359 | A0A2R8Y359_HUMAN | SLC33A1 | 267 | ||
A0A2R8Y5I5 | A0A2R8Y5I5_HUMAN | SLC33A1 | 336 | ||
A0A2R8YEX5 | A0A2R8YEX5_HUMAN | SLC33A1 | 265 | ||
A0A2R8YF57 | A0A2R8YF57_HUMAN | SLC33A1 | 447 | ||
H7C577 | H7C577_HUMAN | SLC33A1 | 185 | ||
H7C532 | H7C532_HUMAN | SLC33A1 | 335 | ||
H7C562 | H7C562_HUMAN | SLC33A1 | 269 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
D88152 EMBL· GenBank· DDBJ | BAA20072.1 EMBL· GenBank· DDBJ | mRNA | ||
AK312268 EMBL· GenBank· DDBJ | BAG35199.1 EMBL· GenBank· DDBJ | mRNA | ||
CH471052 EMBL· GenBank· DDBJ | EAW78743.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471052 EMBL· GenBank· DDBJ | EAW78744.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC014416 EMBL· GenBank· DDBJ | AAH14416.1 EMBL· GenBank· DDBJ | mRNA |