N9Z0C5 · N9Z0C5_9FIRM

  • Protein
    Histidine biosynthesis bifunctional protein HisIE
  • Gene
    hisI
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.
Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionphosphoribosyl-AMP cyclohydrolase activity
Molecular Functionphosphoribosyl-ATP diphosphatase activity
Biological ProcessL-histidine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Histidine biosynthesis bifunctional protein HisIE

Including 2 domains:

  • Recommended name
    Phosphoribosyl-AMP cyclohydrolase
  • EC number
  • Short names
    PRA-CH
  • Recommended name
    Phosphoribosyl-ATP pyrophosphatase
  • EC number
  • Short names
    PRA-PH

Gene names

    • Name
      hisI
    • Synonyms
      hisIE
    • ORF names
      HMPREF1097_04917

Organism names

  • Taxonomic identifier
  • Strain
    • 90B8
  • Taxonomic lineage
    Bacteria > Bacillota > Clostridia > Lachnospirales > Lachnospiraceae > Enterocloster

Accessions

  • Primary accession
    N9Z0C5

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region1-350Phosphoribosyl-AMP cyclohydrolase
Domain261-334Phosphoribosyl-AMP cyclohydrolase
Region351-437Phosphoribosyl-ATP pyrophosphohydrolase

Sequence similarities

Belongs to the HisA/HisF family.
In the C-terminal section; belongs to the PRA-PH family.
In the N-terminal section; belongs to the PRA-CH family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    437
  • Mass (Da)
    49,041
  • Last updated
    2013-06-26 v1
  • Checksum
    910468DA030CCC48
MTDCKKLIMGFGYRNGKTFSWNGKLEYEGGLKELARTACDNGADEIFICDRSFSDEDHEAVIGAIKETARTVDEPILAGGRIRRLEDVKKYLYAGASAVFLDVSYEDNVDMMKEAADRFGSEKIYAYMPDLSYLNRVEEYIQLGASVMICRASGPVLSLAELGEIGEISCRSLIFCGGHENVQEMAGDLKLSLGCPQVEGAVLTLAEDNLDKVMELKQILKGAGIVTDTFESSLEWKNFKLGSDGLIPVIVQDYKTLEVLMMAYMNEESFQATLASGRMTYFSRSRQKLWLKGETSGHFQYVKSLKIDCDNDTILASVKQVGAACHTGNRSCFFTTLAEKEYKETNPLKVFEEVFGVILDRKEHPKEGSYTNYLFDKGIDKILKKLGEEATEIVIAAKNPNPEEIKYEISDFLYHMMVLMADRGITWEEITEELANR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AGYG01000030
EMBL· GenBank· DDBJ
ENZ33135.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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