N9U4L4 · N9U4L4_9GAMM

Function

function

Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide: step 1/2.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site305-316ATP (UniProtKB | ChEBI)
Binding site676ATP (UniProtKB | ChEBI)
Binding site677Mg2+ (UniProtKB | ChEBI)
Binding site716Mg2+ (UniProtKB | ChEBI)
Binding site720Mg2+ (UniProtKB | ChEBI)
Binding site884Mg2+ (UniProtKB | ChEBI)
Binding site886ATP (UniProtKB | ChEBI)
Active site1135Nucleophile
Active site1260
Active site1262

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionphosphoribosylformylglycinamidine synthase activity
Biological Process'de novo' IMP biosynthetic process
Biological Processglutamine metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoribosylformylglycinamidine synthase
  • EC number
  • Short names
    FGAM synthase
    ; FGAMS
  • Alternative names
    • Formylglycinamide ribonucleotide amidotransferase
      (FGAR amidotransferase
      ; FGAR-AT
      )

Gene names

    • Name
      purL
    • ORF names
      G114_03102

Organism names

  • Taxonomic identifier
  • Strain
    • 2478-85
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Aeromonadales > Aeromonadaceae > Aeromonas

Accessions

  • Primary accession
    N9U4L4

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain35-148Phosphoribosylformylglycinamidine synthase N-terminal
Domain169-218Phosphoribosylformylglycinamidine synthase linker
Region300-325Disordered
Domain430-587PurM-like C-terminal
Domain833-966PurM-like C-terminal

Sequence similarities

In the N-terminal section; belongs to the FGAMS family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,296
  • Mass (Da)
    140,570
  • Last updated
    2013-06-26 v1
  • Checksum
    B0AABAAB63D11AB0
MEILRGAPALSEFRVQKLMQSLAERGVEITGIYAEFMHFAELVDPLSPDERATLDRLLRYGPTIPEHAPQGHLFLVTPRPGTISPWSSKATDIAHNCGLTKVKRLERGVAYYVEGQVTDANRGQIAALLHDRMMETVFDAMGAASALFAHHEPRPFTQVDVLGGGRDALAQANLSLGLALADDEIDYLVANFQRLGRNPNDIELYMFAQANSEHCRHKIFNADWIIDGEAQPKSLFKMIKNTFEQTPDYVLSAYKDNAAVMEGSLGGRFFPSPESGEYDYHQEQVDILMKVETHNHPTAISPFPGAATGSGGEIRDEGATGRGAKPKAGLVGFSVSNLRIPGFEQPWEQDFGKPSRIVSAFDIMQDGPLGGAAFNNEFGRPAILGYFRTFEEEVESHNGREVRGYHKPIMLAGGIGNIRTDHVQKGEFPAGSALIVLGGPAMNIGLGGGAASSMTSGQSAEDLDFASVQRDNPEMERRCQEVIDRCWQLGDDNPILFIHDVGAGGLSNAMPELVSDGGRGGRFDLRAIPNDEPGMSPLEIWCNESQERYVLAVAQDKLPLFKVLCERERAPYAVIGTATEEPHLTLSDSHFDNQPIALPLEVLLGKPPKMLRDVTTQQADGQALRLDGVTLGEAALRVLRLPTVAEKSFLITIGDRSVTGLVNRDQMVGPWQIPVADCAVTAATYDSYHGEAMSMGERTPLALLSHAASARMAVAEALTNIAPTNIGSLKRIKLSANWMAAAGHPGEDAGLYEAVKAVGEELCPALGLTIPVGKDSMSMKTRWQQDGEERSNTAPLSLVISAFARVEDVRKTVTPELRTDLGESDLILIDLGHGKQRLGGSALAQVYRQLGQSAPDLDNPVLLKGFFNAIQALVSDGRLLAYHDRSDGGLLVTLLEMAFAGHCGLNIELDRVGGEVLPALFNEELGAVIQVRREDKEAVMTLLAGHGLAACAHVIGTVTSGDEIVLRRAGGELWRESRTHLRTVWGETSWQMQRLRDNPECADNEHAARQDATDPGLQATLTYNPSDDVAAPYIAKGASPRLAVLREQGVNSHVEMAAAFDRAGFTAVDVHMSDILGGRIALDGFQALVACGGFSYGDVLGAGEGWAKSILFNGAAREQFQRFFERGDTLSLGVCNGCQMMSNLRELIPGADLWPRFVRNRSERFEARFSLVEVQGSPSAFFADMVGSVMPIAVSHGEGRVELRDEAHLAALDASGLVGLRFVDNRGGATERYPANPNGSPRGITAVTTTDGRATIMMPHPERVFRTVANSWHPDNWGEDGAWMRMFRNARVALGR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
APVG01000005
EMBL· GenBank· DDBJ
ENY73299.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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