N2BJ84 · N2BJ84_9ACTN

Function

function

Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per subunit.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site61Zn2+ 1 (UniProtKB | ChEBI)
Binding site63Zn2+ 1 (UniProtKB | ChEBI)
Binding site63-65substrate
Binding site95substrate
Binding site153Zn2+ 1 (UniProtKB | ChEBI)
Binding site153Zn2+ 2 (UniProtKB | ChEBI)
Binding site180Zn2+ 2 (UniProtKB | ChEBI)
Binding site233Zn2+ 2 (UniProtKB | ChEBI)
Binding site280substrate
Active site307
Binding site307Zn2+ 1 (UniProtKB | ChEBI)
Binding site311substrate
Binding site325-326substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionallantoinase activity
Molecular Functiondihydroorotase activity
Molecular Functionzinc ion binding
Biological Process'de novo' UMP biosynthetic process
Biological Processpurine nucleobase catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dihydroorotase
  • EC number
  • Short names
    DHOase

Gene names

    • Name
      pyrC
    • ORF names
      HMPREF1091_00801

Organism names

  • Taxonomic identifier
  • Strain
    • 10063974
  • Taxonomic lineage
    Bacteria > Actinomycetota > Coriobacteriia > Coriobacteriales > Atopobiaceae > Atopobium

Accessions

  • Primary accession
    N2BJ84

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain52-423Amidohydrolase-related

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    430
  • Mass (Da)
    46,630
  • Last updated
    2013-06-26 v1
  • Checksum
    3D9B889038A56864
MAFLLKAAHVVDPSVSLDEICDVLIEDDKIAQVGQNLTAPQDAQVIDATGKYLVPGLVDMHVHFRDPGFEYKETIETGSRAAVHGGFTDVATMPNTDPITDSGAEIRYQIDRAREAGYAHVRPLGALTRGEKGEALAEIGDMVMEGACGFSDDGHGVQSAGMMRTCMEYVSQFDRVAIAHCEDESLSSHGVINEGFTSTRLGMFGWPALGEELEIYRDIELCRLTGCPLHIAHISTKKGLDLVRAAKAEGLPVTCEVTPHHLFLCEDDITDTYDTNLKMNPPLRLASDAQALREGLLDGSIDCVVTDHAPHAAHEKDCEWEIAFFGMIGLETSLPLMLTKLVLPGKMSWSQLVEVMAINPRKILRLAPVSIAEGSVADLTLIDPSQTRVITKEYFESKSKNSAFLGDELTGFASDVFVAGKQVVVNGDVA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AGXC01000002
EMBL· GenBank· DDBJ
EMZ41827.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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