N1PZ58 · VEA_DOTSN

Function

function

Component of the velvet transcription factor complex that controls sexual/asexual developmental ratio in response to light, promoting sexual development in the darkness while stimulating asexual sporulation under illumination (By similarity).
The velvet complex hat acts as a global regulator for secondary metabolite gene expression (PubMed:22227160).
Controls the expression of the dothistromin gene cluster (PubMed:22227160).
Regulates hyphal growth and pigment formation (PubMed:22227160).
Acts as a positive regulator of virulence (PubMed:22227160).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Biological Processsporulation resulting in formation of a cellular spore

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Developmental and secondary metabolism regulator veA
  • Alternative names
    • Velvet complex subunit A

Gene names

    • Name
      veA
    • ORF names
      DOTSEDRAFT_69562

Organism names

Accessions

  • Primary accession
    N1PZ58

Proteomes

Subcellular Location

Nucleus
Cytoplasm
Note: Enriched in the nucleus in the dark (By similarity).

Keywords

Phenotypes & Variants

Disruption phenotype

Impairs the biosynthesis of secondary metabolites, including dothistromin (PubMed:22227160).
Impairs asexual sporulation but shows normal hydrophobicity (PubMed:22227160).

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004357701-611Developmental and secondary metabolism regulator veA

Interaction

Subunit

Component of the heterotrimeric velvet complex composed of laeA, veA and velB; VeA acting as a bridging protein between laeA and velB (By similarity).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias, domain, motif.

TypeIDPosition(s)Description
Region1-57Disordered
Compositional bias11-43Polar residues
Domain24-216Velvet
Motif38-43Nuclear localization signal
Compositional bias222-242Basic and acidic residues
Region222-497Disordered
Compositional bias272-323Polar residues
Compositional bias324-365Pro residues
Compositional bias385-401Polar residues
Compositional bias415-447Polar residues
Region455-499PEST
Compositional bias511-534Polar residues
Region511-611Disordered
Compositional bias550-579Polar residues

Domain

The C-terminal PEST domain is a region rich in proline, glutamic acid, serine and threonine residues that is required for the light-dependent regulation of development and secondary metabolism (By similarity).

Sequence similarities

Belongs to the velvet family. VeA subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    611
  • Mass (Da)
    67,573
  • Last updated
    2013-06-26 v1
  • Checksum
    63F2694D9B4E0BC5
MNRKTHIPVENETKSSATRTTNDGRAITYEMQVLQQPQRARACGQGAKSSADRRPVDPPPIVELKIFEGEKRDDITYTMHANYFLFATLEQARPIAHARGQDRNTHPVLTGTPVAGMVYLDRPTPAGYFIFPDLSVRHEGEYRLSFSLYEELKNPKDEDKPEEACDAAGGDAHVTHRLEVKSAPFHVYSAKKFPGLTESTHLSRMVAEQGCRVRIRRDVRMRRREPKSGGKDWDEYEEDTAAARARASATPDPSINGYMQTPHGFIEPNPRPRSASNASHQSLGSISRRPSMQEMGQAYHQQPHYGTAPHTPQNGYTQTAPYGPPPGQQYPPNQFVQQQPPMQPPLPQYQPPNYPAPPPPVTAAQQPQPAQSYYNYPAAPPPPQATQVQQYNVSAHAYDSGVQSHRPSIDFPAQDGYRRNSQQIPPTSQPTAYTQPMQPQYAAQMPPAQHYQQPPPPPPSQASQHSSYSSMDLYNSRPAPIEPHHHGNTPASKASFDLPPINTAAMVSNKLEASSPTSVAPTNAYFSGGQTPIDTHKRSYGDVFSNRHHNAPLRQGQRPSYGQGDSLVTGTTMSAADDDDNASSELDPSTLGMHYRRADGRQIQRALPGHA

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias11-43Polar residues
Compositional bias222-242Basic and acidic residues
Compositional bias272-323Polar residues
Compositional bias324-365Pro residues
Compositional bias385-401Polar residues
Compositional bias415-447Polar residues
Compositional bias511-534Polar residues
Compositional bias550-579Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KB446536
EMBL· GenBank· DDBJ
EME47645.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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