N1PCR8 · N1PCR8_DOTSN

Function

function

ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.

Catalytic activity

  • Hydrolysis of proteins in presence of ATP.
    EC:3.4.21.53 (UniProtKB | ENZYME | Rhea)

Features

Showing features for binding site, active site.

111121002003004005006007008009001,0001,100
Type
IDPosition(s)Description
Binding site599-606ATP (UniProtKB | ChEBI)
Active site979
Active site1022

GO annotations

AspectTerm
Cellular Componentmitochondrial matrix
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent peptidase activity
Molecular Functionsequence-specific DNA binding
Molecular Functionserine-type endopeptidase activity
Molecular Functionsingle-stranded DNA binding
Biological Processcellular response to oxidative stress
Biological Processchaperone-mediated protein complex assembly
Biological Processmitochondrial protein catabolic process
Biological Processoxidation-dependent protein catabolic process
Biological Processprotein quality control for misfolded or incompletely synthesized proteins

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Lon protease homolog, mitochondrial
  • EC number

Gene names

    • Name
      PIM1
    • ORF names
      DOTSEDRAFT_75694

Organism names

Accessions

  • Primary accession
    N1PCR8

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homohexamer or homoheptamer. Organized in a ring with a central cavity.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region40-154Disordered
Compositional bias53-72Polar residues
Compositional bias73-104Basic and acidic residues
Domain163-446Lon N-terminal
Region289-328Disordered
Compositional bias298-328Basic and acidic residues
Region818-848Disordered
Domain887-1073Lon proteolytic
Compositional bias1082-1101Basic and acidic residues
Region1082-1112Disordered

Sequence similarities

Belongs to the peptidase S16 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,112
  • Mass (Da)
    122,166
  • Last updated
    2013-06-26 v1
  • Checksum
    273536AEF20731B3
MVYGRGQAWRTALRQASNRAYTITGAPCRACQAQLTSRPTPLQAHRRIQHPYLPSSITLSRDFSSSPARRKQKPSINPEDGAEAKEESSEEAKEKEEEVEAKGKSPEPTPIPGADGKAASAGSGGNGDSGNPFGNTGDGGNRKGKGKGKDLVKPQVPDVYPQVLAIPIAQRPLFPGFYKAITIRDPNVVAAVQELLKRGQSYVGAFLLKDQESSQDVINDPSEVYDVGTFCQVTGAFPAGHGEDKALQAVLYPHRRIKLSELIPPNRGPPAAPEPEKAAKAAIETVAPTPAPAPEETAKPAEGEDKSGDVVASFEEKEVSAEQKKEQEQKLLQPTDFLRSWPVSLVKVDNLADEPCDKRSPTIRALISEIVNTCKEIGSYNHLFRDHVSAFAMSQSAANIADEPAKLADFAAAVSGGEMEEAQNVLSELNIERRLSKALEVIKKEHMNAQLSNKISKDVESKIQKRQREYWLMEQMKGIRRELGLESDGKDKLVEKFKEKATKLAMPEAVKKVFDEEVNKLAHLEPAASEFNVTRNYLDWLTQIPWGQRSAENFGIQHARDVLDEDHHGLKDVKDRILEFIAVGKLRGTVEGKILCMVGPPGVGKTSIGKSIARALNRQYYRFSVGGLTDVAEIKGHRRTYVGALPGRIIQALKKCQTENPLILIDEVDKIGRGHQGDPSSALLELLDPEQNSSFLDHYMDVPVDLSKVLFVCTANMTDTIPRPLLDRMEMIELSGYVSDEKMAIAERYLAPQAKELSGLKDVAVNLDKEAILELINKYCRESGVRNLKKQIEKVYRKSALKIIQDLGEDAFSEEKALTDEGKAAAEESKKDETDVKETPETIEQETTEKPRVALKVPDSVNVSIGKDNLKDYVGPPVFTADRLYDVTPPGVAMGLAWTSMGGAALYIESILQNALSYSSRPGLERTGNLKNVMKESTLIAYSFVKGLMAKQYPGNKFFEKANIHLHCPEGAVQKDGPSAGITMATSLLSLAFDNPLDPTIAMTGELTVTGKVLRIGGLREKTVAARRAGARMIIFPRDCMSDWLELPENIKEGIEGKPVDWYSDVFKLVFPDVDEAQANGMWKKELAKPPKEEQEEKSGIPDELYSGNLAS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias53-72Polar residues
Compositional bias73-104Basic and acidic residues
Compositional bias298-328Basic and acidic residues
Compositional bias1082-1101Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KB446547
EMBL· GenBank· DDBJ
EME38194.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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