N0DWW7 · N0DWW7_9BIVA
- ProteinADP/ATP translocase
- Geneant
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids135 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.
Catalyzes the exchange of ADP and ATP across the membrane.
Catalytic activity
- ADP(in) + ATP(out) = ADP(out) + ATP(in)This reaction proceeds in the forward direction.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Molecular Function | ATP:ADP antiporter activity | |
Biological Process | mitochondrial ADP transmembrane transport | |
Biological Process | mitochondrial ATP transmembrane transport | |
Biological Process | negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameADP/ATP translocase
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Spiralia > Lophotrochozoa > Mollusca > Bivalvia > Autobranchia > Heteroconchia > Euheterodonta > Imparidentia > Adapedonta > Solenoidea > Pharidae > Ensis
Accessions
- Primary accessionN0DWW7
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 54-76 | Helical | |||
Transmembrane | 91-112 | Helical | |||
Keywords
- Cellular component
Interaction
Subunit
Monomer.
Structure
Sequence
- Sequence statusFragment
- Length135
- Mass (Da)14,681
- Last updated2013-06-26 v1
- MD5 Checksum0F8EAB6A9A851629BEB0197C750C490E
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Non-terminal residue | 135 | ||||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
HE661835 EMBL· GenBank· DDBJ | CCF79031.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HE661836 EMBL· GenBank· DDBJ | CCF79032.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HE661837 EMBL· GenBank· DDBJ | CCF79033.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HE661838 EMBL· GenBank· DDBJ | CCF79034.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HE661840 EMBL· GenBank· DDBJ | CCF79036.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HE661841 EMBL· GenBank· DDBJ | CCF79037.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HE661842 EMBL· GenBank· DDBJ | CCF79038.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HE661843 EMBL· GenBank· DDBJ | CCF79039.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HE661844 EMBL· GenBank· DDBJ | CCF79040.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HE661845 EMBL· GenBank· DDBJ | CCF79041.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HE661846 EMBL· GenBank· DDBJ | CCF79042.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HE661847 EMBL· GenBank· DDBJ | CCF79043.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HE661848 EMBL· GenBank· DDBJ | CCF79044.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HE661849 EMBL· GenBank· DDBJ | CCF79045.1 EMBL· GenBank· DDBJ | Genomic DNA |