M9ZTX7 · M9ZTX7_ZIPCA

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Cu cation (UniProtKB | Rhea| CHEBI:23378 )

Note: Binds a copper A center.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespirasome
Molecular Functioncopper ion binding
Molecular Functioncytochrome-c oxidase activity
Biological ProcessATP synthesis coupled electron transport

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 2

Gene names

    • Name
      COII
    • Synonyms
      cox2

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strains
    • SWFSC ID z0079893
    • SWFSC ID z0094591
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Whippomorpha > Cetacea > Odontoceti > Ziphiidae > Ziphius

Accessions

  • Primary accession
    M9ZTX7

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane27-46Helical
Transmembrane66-85Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-91Cytochrome oxidase subunit II transmembrane region profile
Domain92-225Cytochrome oxidase subunit II copper A binding

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    227
  • Mass (Da)
    26,019
  • Last updated
    2013-06-26 v1
  • Checksum
    57A35FD19848D597
MAYPFQLGFQDATSPIMEELLHFHDHTLMIVFLISSLVLYVITLMLTTKLTHTSTMDAQEVETIWTVLPAIILIMIALPSLRILYMMDEINNPSLTVKTMGHQWYWSYEYTDYENLNFDSYMIPTSDLKPGELRLLEVDNRMVIPMEMTVRVLVSSEDVLHSWAVPSLGLKTDAIPGRLNQTTLMSTRPGLFYGQCSEICGSNHSFMPIVLELVPLENFEKWSTSML

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KC776700
EMBL· GenBank· DDBJ
AGK38003.1
EMBL· GenBank· DDBJ
Genomic DNA
KC776703
EMBL· GenBank· DDBJ
AGK38042.1
EMBL· GenBank· DDBJ
Genomic DNA
LN997430
EMBL· GenBank· DDBJ
CUW00929.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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