M9WEA6 · M9WEA6_9FLAV

  • Protein
    Genome polyprotein
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Predicted
  • Annotation score
    5/5

Function

function

Component of the viral RNA replication complex that functions in virion assembly and antagonizes the host immune response.
Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.
Required cofactor for the serine protease function of NS3. May have membrane-destabilizing activity and form viroporins.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentextracellular region
Cellular Componenthost cell endoplasmic reticulum membrane
Cellular Componenthost cell nucleus
Cellular Componentmembrane
Cellular Componentviral capsid
Cellular Componentvirion membrane
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular FunctionmRNA (nucleoside-2'-O-)-methyltransferase activity
Molecular FunctionmRNA 5'-cap (guanine-N7-)-methyltransferase activity
Molecular Functionprotein dimerization activity
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionRNA binding
Molecular FunctionRNA helicase activity
Molecular FunctionRNA-dependent RNA polymerase activity
Molecular Functionserine-type peptidase activity
Biological Processfusion of virus membrane with host endosome membrane
Biological Processproteolysis
Biological Processsymbiont entry into host cell
Biological Processsymbiont-mediated suppression of host innate immune response
Biological Processsymbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity
Biological Processsymbiont-mediated suppression of host type I interferon-mediated signaling pathway
Biological Processviral RNA genome replication
Biological Processvirion attachment to host cell
Biological Processvirus-mediated perturbation of host defense response

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Genome polyprotein

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • AEFV-SPFLD-MO-2011-MP6
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Kitrinoviricota > Flasuviricetes > Amarillovirales > Flaviviridae > Orthoflavivirus

Accessions

  • Primary accession
    M9WEA6

Proteomes

Subcellular Location

Host endoplasmic reticulum membrane
; Multi-pass membrane protein
Host endoplasmic reticulum membrane
; Peripheral membrane protein
Host endoplasmic reticulum membrane
; Peripheral membrane protein
Host nucleus
Secreted
Virion membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane71-94Helical
Transmembrane114-133Helical
Transmembrane669-696Helical
Transmembrane1109-1127Helical
Transmembrane1139-1166Helical
Transmembrane1178-1199Helical
Transmembrane1205-1225Helical
Transmembrane1232-1251Helical
Transmembrane1308-1324Helical
Transmembrane1330-1347Helical
Transmembrane1406-1428Helical
Transmembrane2088-2113Helical
Transmembrane2134-2163Helical
Transmembrane2183-2202Helical
Transmembrane2296-2325Helical

Keywords

PTM/Processing

Keywords

Interaction

Subunit

Forms a heterodimer with serine protease NS3. May form homooligomers.
Forms heterodimers with envelope protein E in the endoplasmic reticulum and Golgi.

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region1-54Disordered
Compositional bias37-54Polar residues
Domain1452-1630Peptidase S7
Domain1627-1780Helicase ATP-binding
Domain2454-2706MRNA cap 0-1 NS5-type MT
Domain2970-3117RdRp catalytic

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    3,341
  • Mass (Da)
    372,633
  • Last updated
    2013-06-26 v1
  • Checksum
    AF7250F09A09EDD5
MNRMLLKKGPSGQTSGRPSTRPPDPAEKRVKRAAGNKTSKNQRPSTRGATPSSLLTSLFGRRKGGEWLRILQLDIGAAVLWLALAVGSLGQQLWRQITMLKKRVNRLEAQRSHSPVFFVCLAFLFGLALSETLRYGTDGNGKLTLETEDGTAIDSLNYKLPADACLVGLPIEKHCPLVSKLADLDNIDCGSTSEEFRLKYNRCQVTPRKRRSSQPRPASHTGLIEEVELLTFKFTREHMPILVVCLLVVSVARKWPMWSVVAISVLTWNVVRATSIEPLYTITATGTSMSHTRILSNEMYSISTTRGLIHLDIHNITVQGERPFKTLLTSCEIVESVSEDTCPGGSHLEMAKLRRANRTCKVDAFNRGWGTGCFEWGLGQVATCVEVQCLTMVNVSVLVDSVIQATASMELHGHQDSRAVLRDVPTVFHFGDIGTITLTCGATTDRLASQHYHVRDSSKSGLVLKEAVDAWPGVIRLGEYTSGMEKIINWGVTTANEIKVDSVNNPQIDWKGSVIQDIRSISFTCEMIFENVTFTSLPLCVGNLSGVFVQNGYGRDGVVSIILEESTPQACSIPISSRGCTVVGSTVIVAAKSQSGRAYVMCGNGTGHVELADSVVPVDCLVTPVAQAWRLMTHVAGRYSKHGMAGIGSVWEDLVRNFHFSWSWIPGGWLVPVVLIVLSIVFLGRGVTLVIVVVIASMYIRRVAGDIGCGIDTTRRTISCGQGAFVWKQLGSGPMKDHSVELDDYAFTNLYIRDMFDGTNKPCLICEDTLQCAALRRAAVAARIAMHPGVMYVNTTLSYNRTFVETRKRVLTVTLESLEYKVGSYVTHGRLEGDMGYLPTSFGSHPERETDKVLRIVAARPDIRRMCGKAIAFQFTFTGFRRSLYGSNVQVAVSKHVTRHCPTYLAGVAVKNDRTIITDGMFWMESEIVNGTQRIVVLEMLQSHRCLWPSSYTPDALSDPTDMNIFVPPAWGGPISKANHVPGYKMQTDFPWSSPEISLHQGPVPGTQVTIDPKCDGRMQAKPVDPESNVTWCCKTCDAIIHFRVGEEFFYPMEIQPGTMASRENPRPKIVETPLDGEEEPLMDDILGRYGRADATADFHRRNPRSGGGFDRSVLNLLCLAIALQLIGARTRATTWSRLILTTVAMLTFGLPNIFSSVGLSAWVFLVASSAYQPIDVVMNLWIILQTGSSAVILLGFMVRRKLSIVLGHHHLMASICLQFLFWVVERQQRAFSVFLEAVAAIVLIGAYRGMTQDLPPEILTFCLIMGWKTALALGTVALLTQGTSAFYKWTQKSLESKSSYRTSGRSAWFWTISCASAGAIWAAERADHPSAAAVLALITIIAFLYMDQANVTMELEFLSTGDVPDGIALEEDEGGNFRDLRGTYSDEGITIGQDMGSAQIPETMVIILIGCALTSASLFVGALYTILAISTNIPRNLFRLCRLKINEHCRSDDLLGFGGESTQKIETSFGDLPNGIYRINVRSFMENRQRGVGVAKNGVFHTLMHVTRGEPLKWREKLVSLHSGSALRDVVSYGGPWQLESPTVAEEISLMACKPDKTVEYHKYKPGVVKLDNENVMFISVDFGKGSSGSPFFVNGEVVGFYGFGFYVNGVYRSIVAGGRPGDIAPNEVADSTRKFITWHPGKGKTRRVIVSEVKANFDAGLRTIILTPTRVVMAEVMEALGQAGITCDRNLMYCRRNLVTVACHATFTKLVLSHGVKKIGVALIIMDECHFMDPMSIAARGVMEHLHEKGTKLMYLSATPPGHSPDGGSNFPIHDQAIAFPSWMTPAWINSVRKSRNSKKAIMFVPSHTQANSLAATIPGAVPLHRANFAANYARASNDETSLVVSTDISEMGANLGVDMVIDTRKVLRPLVASENRIKLTETNVTTSSMIQRRGRTGRRGPGSYVFPVDSQTEENPVGWACWPEAQMLLDQIGMTFMPEEAMYSQPPGRYTLVGEDLLRFMKFLDKDDIPTWLAWHWAEAADRRHSALFQGNSTGQMLETRYGRMEYRPMYVDDRFENIEWDQRRLSIEMYINTRSSASLYDILFSFDWHGIWKKTTSSLWDLRDIVSGDLHDQILAEQSLTSGMAFMLGCAIAVALLMFLWVFICLVSYSRSGKNSFEPMPVSDPLGGGFFLTSPGVLHYFGVPLGFCVIIFLAMFIVYPVLYKAAGNRSYLDSDLVKWVILGSCVMCSVLAWEMRLFPNIREDIKNIMATSNRMENQAPPTPTAWFTPTPWNGGANQLDTLQVFFCATILLNKFAFWIQENWTSQMYVMKHPEMVGTVGGFRLDHIPFRAVIPSCFVITMTVGLPSVVIGAGAAALFMFITYHQNKWNATPKIISALDARDQKHDRPTDIADRVSVDNTRAVMYSYCMVLSLLWVFCTRSPSDIPRTILVVCACLWQLLNPRSHIHDVMDFGSMLSAIGLIDMNFLFYKFLHIAMRALGAMAPFSKFRALEKSTTIGLGIKWKFMLNALDKDAFERYKVRGVNETGKGDYVSRGGLKLDEIIRKYQWTPMGHVVDLGCGRGGWSQRVVMEETVTSVHGFTIGGNDKENPQRFVTRGYNLTSLKPGVDVYKLEPKRCDTIMCDIGESDPNLTKERTRTLKVLQLLETWLAINPEAQFVCKVLSPYSLEVLRKVESLQQKYKGKLVRLAHSRNSTAEMYYISGNRSNAVRDAYMTLAALIGRFSRHIDSVFLPEPTLPRGTRADPAASVSAMNVDDMVDRVRKVQQENSATWFIDPEHPYKSFRYFGSFVTDDVKVGGQAVNPLVRKIMWPWETVTSVVSFLMTDVSTYSQQKILREKVDTVIPPHPPQIRMVNSLITKHFIRIFKRRGLTPRIMTKEEFIANVRNDAAVGSWSRDVPWRDVQEAVQDQGFWNLVGHERALHLQGKCSMCLYNTMGKKEKKPSVAGEAKGSRTIWYMWLGSRFLEFEALGFLNADHWVSRENFPGGVGGVGVNYFGNYLKEISLKGKYLFADDIAGWDTKVSSEDLEDEETLLTELTANPFHRALIAATMKLAYRNIVAMFPRTHTRYGSGTVMDVVGRTDQRGSGQVVTYALNTITNGKVQVARTLESEGLLYADTQVIDRWLSKNLDDVLSCMTIAGDDVVVSTMNRSFASSLDYLELTGKTRKNVPRGAPSKMESDWQKVEFCSHHYHELSLRDGRILIVPCRQESEVVGRSRLQKGGIVTMAESACMAKAYAQMWALYFFHRRDLRLGFAAITSAVPSNWFPVGRTSWSVHQFHEWMTTSDMLRVWNDVWIYNNPWIRVKDPIGSWDEIPYLHKRQDIACGSLIGSKERAAWAREIENGVISVRKILNAESKCDNVYNDGLVIMSRFRKSNDVI

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias37-54Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KC181923
EMBL· GenBank· DDBJ
AGJ91136.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp