M9PFR5 · M9PFR5_DROME
- ProteinLysine-specific histone demethylase
- GeneSu(var)3-3
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids870 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3.
Catalytic activity
- N6,N6-dimethyl-L-lysyl4-[histone H3] + 2 A + 2 H2O = L-lysyl4-[histone H3] + 2 formaldehyde + 2 AH2
Cofactor
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 247-275 | FAD (UniProtKB | ChEBI) | |||
Binding site | 276 | FAD (UniProtKB | ChEBI) | |||
Binding site | 282 | FAD (UniProtKB | ChEBI) | |||
Binding site | 298-299 | FAD (UniProtKB | ChEBI) | |||
Binding site | 780 | FAD (UniProtKB | ChEBI) | |||
Binding site | 789-790 | FAD (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | FAD-dependent H3K4me/H3K4me3 demethylase activity | |
Molecular Function | flavin adenine dinucleotide binding | |
Biological Process | regulation of DNA-templated transcription |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameLysine-specific histone demethylase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionM9PFR5
Proteomes
Organism-specific databases
Subcellular Location
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1-17 | Polar residues | |||
Region | 1-164 | Disordered | |||
Compositional bias | 52-81 | Basic and acidic residues | |||
Compositional bias | 82-142 | Polar residues | |||
Domain | 172-228 | SWIRM | |||
Domain | 254-804 | Amine oxidase | |||
Region | 840-870 | Disordered | |||
Compositional bias | 841-870 | Polar residues | |||
Sequence similarities
Belongs to the flavin monoamine oxidase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length870
- Mass (Da)95,947
- Last updated2013-06-26 v1
- ChecksumAB832D51387EAFEB
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1-17 | Polar residues | |||
Compositional bias | 52-81 | Basic and acidic residues | |||
Compositional bias | 82-142 | Polar residues | |||
Compositional bias | 841-870 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE014296 EMBL· GenBank· DDBJ | AGB94793.1 EMBL· GenBank· DDBJ | Genomic DNA |