M9PFR5 · M9PFR5_DROME

Function

function

Histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3.

Catalytic activity

Cofactor

FAD (UniProtKB | Rhea| CHEBI:57692 )

Features

Showing features for binding site.

1870100200300400500600700800
TypeIDPosition(s)Description
Binding site247-275FAD (UniProtKB | ChEBI)
Binding site276FAD (UniProtKB | ChEBI)
Binding site282FAD (UniProtKB | ChEBI)
Binding site298-299FAD (UniProtKB | ChEBI)
Binding site780FAD (UniProtKB | ChEBI)
Binding site789-790FAD (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular FunctionFAD-dependent H3K4me/H3K4me3 demethylase activity
Molecular Functionflavin adenine dinucleotide binding
Biological Processregulation of DNA-templated transcription

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Lysine-specific histone demethylase
  • EC number

Gene names

    • Name
      Su(var)3-3
    • Synonyms
      dLSD1
      , dLsd1
      , Dmel/HDM
      , Dmel/LSD1
      , Dmel\CG17149
      , Dmel\LSD1
      , Hdm
      , LSD1
      , Lsd1
      , lsd1
      , SU(VAR)3-3
      , Su(Var)3-3
      , Su-var(3)3
      , Suvar(3)3
    • ORF names
      CG17149
      , Dmel_CG17149

Organism names

  • Taxonomic identifier
  • Strain
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    M9PFR5

Proteomes

Organism-specific databases

Subcellular Location

Keywords

  • Cellular component

Expression

Gene expression databases

Structure

Family & Domains

Features

Showing features for compositional bias, region, domain.

Type
IDPosition(s)Description
Compositional bias1-17Polar residues
Region1-164Disordered
Compositional bias52-81Basic and acidic residues
Compositional bias82-142Polar residues
Domain172-228SWIRM
Domain254-804Amine oxidase
Region840-870Disordered
Compositional bias841-870Polar residues

Sequence similarities

Belongs to the flavin monoamine oxidase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    870
  • Mass (Da)
    95,947
  • Last updated
    2013-06-26 v1
  • Checksum
    AB832D51387EAFEB
MKPTQFGGSSSKMTEPIEYVTLISDDSDGEPTPKRNVNHPPSALSAPNPGQKQKHPDEDSNDAPATSDERRTSRRNRPKVDYSNRPSGSGDTASNDKSGSASMGPNNQQAERRSQSQTRKSEANATSSSVSGPSAGNSRPSQNGDSKDRDAGTPTVLSGQEGAVFQSRLPFNKMTPNEEACFPDISRSGILGHRVFLNIRNSLLHMWVDNPKIQLSFEIALKNLPPPFDSEPSLRLKPIPAKKLGKVIVIGAGISGLAVAHQLQQFGMDVIVLEARDRVGGRISTFRKNSYIADVGAMVVTGVYGNPMTILSKQIGMDLVPIQQTCPLYGPDGKPVPKEKDDVIEREFNRLLESASYLSHRLDFNYAGDCPVSLGDALEWIISMQEMQVMHKRGQHMQEIIATQTKIIEQRRRLKTLRDTIGKLKNEHLAMINQRKPKGTDGDLKYCYQEFNIRNTQIKMEETISTFHDLHAEEKQMLAKLHELEQNRPSDVYLSSRDRLILDWHFANLEFANATRLNNLSLKHWDQDDDFEFIGHHTTVRNGYSCVPVALTENLDIRVNSAVKEIKYGTKGVEVVAENLKTSNSQMTYKADLVVCTLTLGVLKVAVAHKESQQSNTVKFDPPLPDWKQQAIKRLGFGNLNKVVLCFDRIFWDPNANLFGHVGSTTASRGEMFLFWSISSSPVLLALVAGMAANLVESVTDDIIIGRCMSVLKNIFGNTSVPQPKETVVTRWRSDPWARGSYSYVSVGSSGSDYDLLAAPVIPPSSKDAEGLPRLFFAGEHTIRNYPATVHGAYLSGLREAGRIADYYLGYPEGTPPDIGYSVAEAANLVSVGNVVKLRDLSPNLSDSSPSSKKSEENSNSNTADSTELQ

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q9VW97LSDA_DROMESu(var)3-3890
B7Z0G7B7Z0G7_DROMESu(var)3-3890

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-17Polar residues
Compositional bias52-81Basic and acidic residues
Compositional bias82-142Polar residues
Compositional bias841-870Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE014296
EMBL· GenBank· DDBJ
AGB94793.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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