M9PEF9 · M9PEF9_DROME
- Proteinmitogen-activated protein kinase kinase
- Genehep
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1162 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Molecular Function | ATP binding | |
Molecular Function | MAP kinase kinase activity | |
Molecular Function | protein serine/threonine kinase activity | |
Biological Process | response to stress |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namemitogen-activated protein kinase kinase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionM9PEF9
Proteomes
Organism-specific databases
PTM/Processing
Keywords
- PTM
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 64-79 | Polar residues | ||||
Sequence: HAPSLGAGSVSGSGIS | ||||||
Region | 64-168 | Disordered | ||||
Sequence: HAPSLGAGSVSGSGISIAQRPAPPVPHATPFGSASASSSSSSASAFASAAPATGTFGGTYTPPTTRVSRATPTLPMLSSGPGGGLNRTRPVILPLPTPPHPPVSE | ||||||
Compositional bias | 94-138 | Polar residues | ||||
Sequence: FGSASASSSSSSASAFASAAPATGTFGGTYTPPTTRVSRATPTLP | ||||||
Domain | 197-456 | Protein kinase | ||||
Sequence: LKHLGDLGNGTSGNVVKMMHLSSNTIIAVKQMRRTGNAEENKRILMDLDVVLKSHDCKYIVKCLGCFVRDPDVWICMELMSMCFDKLLKLSKKPVPEQILGKVTVATVNALSYLKDKHGVIHRDVKPSNILIDERGNIKLCDFGISGRLVDSKANTRSAGCAAYMAPERIDPKKPKYDIRADVWSLGITLVELATARSPYEGCNTDFEVLTKVLDSEPPCLPYGEGYNFSQQFRDFVIKCLTKNHQDRPKYPELLAQPFI | ||||||
Region | 480-679 | Disordered | ||||
Sequence: ANGDPTLQRATATGSAIGSGAGSLAGSGSGSAGGAVKYGRATTYAGQSPTNPQKTIKPTQIPSYQQQQSQFFMQSATQLPQTTTTTPTATTNCFGGSGNGNGRGNGSGGSGNGSGSSSSASPLSPPSAGIGDLNRLYRKSPFMQRKLSNGSHHPHYKYNDESPKKESMFSSIGQSILRNLTTSPFSQKKHNSTATTIPLP | ||||||
Compositional bias | 483-505 | Polar residues | ||||
Sequence: DPTLQRATATGSAIGSGAGSLAG | ||||||
Compositional bias | 522-604 | Polar residues | ||||
Sequence: TYAGQSPTNPQKTIKPTQIPSYQQQQSQFFMQSATQLPQTTTTTPTATTNCFGGSGNGNGRGNGSGGSGNGSGSSSSASPLSP | ||||||
Compositional bias | 644-679 | Polar residues | ||||
Sequence: KESMFSSIGQSILRNLTTSPFSQKKHNSTATTIPLP | ||||||
Compositional bias | 715-796 | Polar residues | ||||
Sequence: TTTPTWRLPTENSQAYDSCDSSSNATTTTLNLGLSSPSPSLPRKQFPTESPTLQLTSQQQQQPQRLQPGNQSPIVLQRFYHQ | ||||||
Region | 715-934 | Disordered | ||||
Sequence: TTTPTWRLPTENSQAYDSCDSSSNATTTTLNLGLSSPSPSLPRKQFPTESPTLQLTSQQQQQPQRLQPGNQSPIVLQRFYHQQNQLREKEAAERYQQQRQQPPVGVTSTNPFHSNYVPPPPSTHSTSSQSSTQSTCSQIAINPASISPSSGSGTGNMAGLGIGSAPASGLGAAGHFGAGGTGEQLQYQPLPIAAEATGTSPTLQSRSPEQQSDYGGNGNM | ||||||
Compositional bias | 810-871 | Polar residues | ||||
Sequence: QQQRQQPPVGVTSTNPFHSNYVPPPPSTHSTSSQSSTQSTCSQIAINPASISPSSGSGTGNM | ||||||
Compositional bias | 907-933 | Polar residues | ||||
Sequence: AAEATGTSPTLQSRSPEQQSDYGGNGN | ||||||
Compositional bias | 950-981 | Polar residues | ||||
Sequence: GQSSSSGASNSSLDGCSREQHDAATSPVASSM | ||||||
Region | 950-1134 | Disordered | ||||
Sequence: GQSSSSGASNSSLDGCSREQHDAATSPVASSMDRDQEPVHPQPPAYRSVVNNGSGGKSYYYRTLSAASSSSNTSQSTSPTTEPLPGGGTSSFLRRYASSGPGGSISTPPSPHILAGLDRRHRSPDPPPRYNRGQSPLLLRKNLLELSGQPPGSPLLHRRYVSASPPLPPPRRGSESVPGSPQHFR | ||||||
Compositional bias | 996-1055 | Polar residues | ||||
Sequence: RSVVNNGSGGKSYYYRTLSAASSSSNTSQSTSPTTEPLPGGGTSSFLRRYASSGPGGSIS |
Sequence similarities
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,162
- Mass (Da)123,289
- Last updated2013-06-26 v1
- Checksum1F106DBF3BE5CEF0
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q23977 | HEP_DROME | hep | 1178 | ||
A0A6H2EEQ6 | A0A6H2EEQ6_DROME | hep | 1294 | ||
A0A6H2EF36 | A0A6H2EF36_DROME | hep | 1187 | ||
X2JJV1 | X2JJV1_DROME | hep | 1153 | ||
M9PH06 | M9PH06_DROME | hep | 492 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 64-79 | Polar residues | ||||
Sequence: HAPSLGAGSVSGSGIS | ||||||
Compositional bias | 94-138 | Polar residues | ||||
Sequence: FGSASASSSSSSASAFASAAPATGTFGGTYTPPTTRVSRATPTLP | ||||||
Compositional bias | 483-505 | Polar residues | ||||
Sequence: DPTLQRATATGSAIGSGAGSLAG | ||||||
Compositional bias | 522-604 | Polar residues | ||||
Sequence: TYAGQSPTNPQKTIKPTQIPSYQQQQSQFFMQSATQLPQTTTTTPTATTNCFGGSGNGNGRGNGSGGSGNGSGSSSSASPLSP | ||||||
Compositional bias | 644-679 | Polar residues | ||||
Sequence: KESMFSSIGQSILRNLTTSPFSQKKHNSTATTIPLP | ||||||
Compositional bias | 715-796 | Polar residues | ||||
Sequence: TTTPTWRLPTENSQAYDSCDSSSNATTTTLNLGLSSPSPSLPRKQFPTESPTLQLTSQQQQQPQRLQPGNQSPIVLQRFYHQ | ||||||
Compositional bias | 810-871 | Polar residues | ||||
Sequence: QQQRQQPPVGVTSTNPFHSNYVPPPPSTHSTSSQSSTQSTCSQIAINPASISPSSGSGTGNM | ||||||
Compositional bias | 907-933 | Polar residues | ||||
Sequence: AAEATGTSPTLQSRSPEQQSDYGGNGN | ||||||
Compositional bias | 950-981 | Polar residues | ||||
Sequence: GQSSSSGASNSSLDGCSREQHDAATSPVASSM | ||||||
Compositional bias | 996-1055 | Polar residues | ||||
Sequence: RSVVNNGSGGKSYYYRTLSAASSSSNTSQSTSPTTEPLPGGGTSSFLRRYASSGPGGSIS |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE014298 EMBL· GenBank· DDBJ | AGB95342.1 EMBL· GenBank· DDBJ | Genomic DNA |