M9PD50 · M9PD50_DROME
- ProteinMediator of RNA polymerase II transcription subunit 13
- Geneskd
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids2601 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | mediator complex | |
Molecular Function | transcription coregulator activity | |
Biological Process | regulation of transcription by RNA polymerase II |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameMediator of RNA polymerase II transcription subunit 13
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionM9PD50
Proteomes
Organism-specific databases
Subcellular Location
Expression
Gene expression databases
Interaction
Subunit
Component of the Mediator complex.
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 12-229 | Mediator complex subunit Med13 N-terminal | ||||
Sequence: SLEDCHTNFYALTDLCGIKWRKFVNGERPNASSDPLADPILRSYSRCIQADMLCVWRRVQSTKTDHADPNALTFEMTTSTKVHPPLSLAAAKELWIFWYGEEPDLSELVDAELLRVAANQALWNGTWKGALTYECRSLLFKALHNLMERFVLTKDIVRFGKWFVQPCTSSDRLFGRSSQHLSFSFTFFVHGDTVCASIDLREHPAVRPLTKEHLTEAA | ||||||
Region | 232-279 | Disordered | ||||
Sequence: FAAASSPPGSNGSAASAGGAVPNPGQDPNGASMDGLDGGEGAAKAAPP | ||||||
Region | 509-543 | Disordered | ||||
Sequence: TPASGTGSLSADGDENEQNKPPQDSKQLVQQQIQQ | ||||||
Region | 569-714 | Disordered | ||||
Sequence: GNTPHGTPHGGASTYSRNSLGGDSSMPVASVESPATPAPSPHPNSAHSQPTSVPPAEQPPTPIDHLLDKNTPAPTPTDQHDSKSITASPYVHQTPSVEPPSYTDHAAGGGPAGGQGLGTGPGSVPAQQPATPTAATSAGGAGSGGP | ||||||
Compositional bias | 575-599 | Polar residues | ||||
Sequence: TPHGGASTYSRNSLGGDSSMPVASV | ||||||
Compositional bias | 640-668 | Polar residues | ||||
Sequence: PAPTPTDQHDSKSITASPYVHQTPSVEPP | ||||||
Compositional bias | 689-711 | Polar residues | ||||
Sequence: PGSVPAQQPATPTAATSAGGAGS | ||||||
Region | 899-940 | Disordered | ||||
Sequence: LNIKTEPGLHSPSCKETSKSSGGNSSGGGSGSGGNLFTAEGL | ||||||
Compositional bias | 909-940 | Polar residues | ||||
Sequence: SPSCKETSKSSGGNSSGGGSGSGGNLFTAEGL | ||||||
Region | 953-977 | Disordered | ||||
Sequence: TSSNDECSSVQIHTPPDSNNPSNGG | ||||||
Region | 1019-1038 | Disordered | ||||
Sequence: TKMFPTPPSHEQQHPNSSPC | ||||||
Compositional bias | 1024-1038 | Polar residues | ||||
Sequence: TPPSHEQQHPNSSPC | ||||||
Coiled coil | 1194-1228 | |||||
Sequence: HQALQQRIQLHQQKLQQLQLQNQQQQQAAAAAAAA | ||||||
Region | 1251-1367 | Disordered | ||||
Sequence: PRTPLTPSTVPQPLSSGGSQYLLNQLNCPQAPPGASMQQLMHRAGMSPISPGPGMGPYAARSSPMSRATPTHPPPPYPYDLAVASPATSTSSYLNRPLHSQEHPHMHGLGGGATGVV | ||||||
Compositional bias | 1252-1284 | Polar residues | ||||
Sequence: RTPLTPSTVPQPLSSGGSQYLLNQLNCPQAPPG | ||||||
Compositional bias | 1334-1348 | Polar residues | ||||
Sequence: ASPATSTSSYLNRPL | ||||||
Region | 1504-1540 | Disordered | ||||
Sequence: ASASMPGAGSGHGHGPNGGSNSSSCTPPSSNPHITGY | ||||||
Compositional bias | 1518-1536 | Polar residues | ||||
Sequence: GPNGGSNSSSCTPPSSNPH | ||||||
Region | 1597-1616 | Disordered | ||||
Sequence: SRKNQNKQGPGETSSALDKI | ||||||
Domain | 1865-2149 | MID | ||||
Sequence: RDVVYVVVCPDNEHVVNCTRSYFRELSSTYEMCKLGKHTPIRGWDGFLQVGAARNNVPADRETTPLDDWLRTLEHAALAEQIRRYAVAFIHQLAPYLSRVPNDKTLLNPPDGSGNSHSKGGSSCSSNSSSVSGLPGGDLPTDNIKLEPGTEPQVQPMETNEIKQEPGVGKGGTAAGETKPTLILGDPLGMGETLEDINPSAIVLYVVNPFTFASDSCELERLALIALLRCYAELLKAVPDSVRSQMNIQIISLESVMELGPCGNRKRFSDEIRCLALNIFSQCRR | ||||||
Region | 1968-2043 | Disordered | ||||
Sequence: KTLLNPPDGSGNSHSKGGSSCSSNSSSVSGLPGGDLPTDNIKLEPGTEPQVQPMETNEIKQEPGVGKGGTAAGETK | ||||||
Compositional bias | 1972-2000 | Polar residues | ||||
Sequence: NPPDGSGNSHSKGGSSCSSNSSSVSGLPG | ||||||
Domain | 2187-2590 | Mediator complex subunit Med13 C-terminal | ||||
Sequence: YTAPFVLAPMHERNDKTDFSRSAGSMHGQNEHRYSVMYCNYCLSEDQAWLLATATDERGEMLEKICINIDVPNRARRRKAPARYVALKKLMDFIMGIISQTSQMWRLVIGRIGRIGHSELKSWSFLLSKQQLQKASKQFKDMCKQCTLMYPPTILSACLVTLEPDAKLRVMPDQFTPDERFSQISMQNPLATPQDVTCTHILVFPTSAVCAPFTRQFQNEPQVDDDFLTFEEEGNEDFSDADIGDLFWDTHMDRVSNHGSPGRMDDNRSWQSAGGNNFKCTPPQEVEEVGSLNQQPISVGYMVSTAPTGRMPAWFWSACPHLEDVCPVFLKTALHLHVPSIQSADDILNSTNAHQSGNDHPLDSNLTADVLRFVLEGYNALSWLALDSNTHDRLSCLPINVQTL |
Sequence similarities
Belongs to the Mediator complex subunit 13 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,601
- Mass (Da)278,205
- Last updated2013-06-26 v1
- ChecksumB77BCEB00D1EBBA4
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 575-599 | Polar residues | ||||
Sequence: TPHGGASTYSRNSLGGDSSMPVASV | ||||||
Compositional bias | 640-668 | Polar residues | ||||
Sequence: PAPTPTDQHDSKSITASPYVHQTPSVEPP | ||||||
Compositional bias | 689-711 | Polar residues | ||||
Sequence: PGSVPAQQPATPTAATSAGGAGS | ||||||
Compositional bias | 909-940 | Polar residues | ||||
Sequence: SPSCKETSKSSGGNSSGGGSGSGGNLFTAEGL | ||||||
Compositional bias | 1024-1038 | Polar residues | ||||
Sequence: TPPSHEQQHPNSSPC | ||||||
Compositional bias | 1252-1284 | Polar residues | ||||
Sequence: RTPLTPSTVPQPLSSGGSQYLLNQLNCPQAPPG | ||||||
Compositional bias | 1334-1348 | Polar residues | ||||
Sequence: ASPATSTSSYLNRPL | ||||||
Compositional bias | 1518-1536 | Polar residues | ||||
Sequence: GPNGGSNSSSCTPPSSNPH | ||||||
Compositional bias | 1972-2000 | Polar residues | ||||
Sequence: NPPDGSGNSHSKGGSSCSSNSSSVSGLPG |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE014296 EMBL· GenBank· DDBJ | AGB94827.1 EMBL· GenBank· DDBJ | Genomic DNA |