M9PCW8 · M9PCW8_DROME
- ProteinPiezo-type mechanosensitive ion channel component
- GenePiezo
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids2838 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | mechanosensitive monoatomic ion channel activity |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended namePiezo-type mechanosensitive ion channel component
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionM9PCW8
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 12-39 | Helical | |||
Transmembrane | 59-89 | Helical | |||
Transmembrane | 204-227 | Helical | |||
Transmembrane | 233-250 | Helical | |||
Transmembrane | 257-278 | Helical | |||
Transmembrane | 325-346 | Helical | |||
Transmembrane | 403-421 | Helical | |||
Transmembrane | 427-449 | Helical | |||
Transmembrane | 461-479 | Helical | |||
Transmembrane | 518-536 | Helical | |||
Transmembrane | 548-568 | Helical | |||
Transmembrane | 588-606 | Helical | |||
Transmembrane | 613-629 | Helical | |||
Transmembrane | 641-661 | Helical | |||
Transmembrane | 694-714 | Helical | |||
Transmembrane | 816-841 | Helical | |||
Transmembrane | 853-872 | Helical | |||
Transmembrane | 914-932 | Helical | |||
Transmembrane | 971-993 | Helical | |||
Transmembrane | 999-1015 | Helical | |||
Transmembrane | 1022-1046 | Helical | |||
Transmembrane | 1066-1091 | Helical | |||
Transmembrane | 1147-1168 | Helical | |||
Transmembrane | 1207-1231 | Helical | |||
Transmembrane | 1275-1293 | Helical | |||
Transmembrane | 2031-2050 | Helical | |||
Transmembrane | 2057-2081 | Helical | |||
Transmembrane | 2106-2124 | Helical | |||
Transmembrane | 2222-2244 | Helical | |||
Transmembrane | 2264-2285 | Helical | |||
Transmembrane | 2297-2316 | Helical | |||
Transmembrane | 2328-2345 | Helical | |||
Transmembrane | 2437-2460 | Helical | |||
Transmembrane | 2719-2742 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 354-375 | Disordered | |||
Compositional bias | 355-375 | Polar residues | |||
Region | 731-772 | Disordered | |||
Domain | 1226-1371 | Piezo | |||
Compositional bias | 1363-1378 | Basic and acidic residues | |||
Region | 1363-1384 | Disordered | |||
Region | 1398-1430 | Disordered | |||
Region | 1606-1656 | Disordered | |||
Compositional bias | 1613-1635 | Polar residues | |||
Compositional bias | 1713-1732 | Basic and acidic residues | |||
Region | 1713-1808 | Disordered | |||
Compositional bias | 1736-1763 | Polar residues | |||
Compositional bias | 1786-1808 | Basic and acidic residues | |||
Region | 1879-1943 | Disordered | |||
Compositional bias | 1881-1896 | Polar residues | |||
Compositional bias | 1903-1922 | Polar residues | |||
Region | 2141-2163 | Disordered | |||
Domain | 2376-2806 | Piezo non-specific cation channel R-Ras-binding | |||
Compositional bias | 2809-2823 | Basic and acidic residues | |||
Region | 2809-2838 | Disordered | |||
Compositional bias | 2824-2838 | Polar residues | |||
Sequence similarities
Belongs to the PIEZO (TC 1.A.75) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,838
- Mass (Da)319,886
- Last updated2016-02-17 v2
- Checksum2B67FCDC63D1BA8E
Computationally mapped potential isoform sequences
There are 10 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
M9MSG8 | PIEZO_DROME | Piezo | 2551 | ||
M9PCC7 | M9PCC7_DROME | Piezo | 2533 | ||
M9PF50 | M9PF50_DROME | Piezo | 2571 | ||
Q9VLS3 | Q9VLS3_DROME | Piezo | 2621 | ||
Q8IPG4 | Q8IPG4_DROME | Piezo | 2709 | ||
A0A0S0WGQ9 | A0A0S0WGQ9_DROME | Piezo | 2973 | ||
E1JHB4 | E1JHB4_DROME | Piezo | 2686 | ||
M9MRE5 | M9MRE5_DROME | Piezo | 2570 | ||
Q0E8L0 | Q0E8L0_DROME | Piezo | 2671 | ||
M9PB69 | M9PB69_DROME | Piezo | 2551 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 355-375 | Polar residues | |||
Compositional bias | 1363-1378 | Basic and acidic residues | |||
Compositional bias | 1613-1635 | Polar residues | |||
Compositional bias | 1713-1732 | Basic and acidic residues | |||
Compositional bias | 1736-1763 | Polar residues | |||
Compositional bias | 1786-1808 | Basic and acidic residues | |||
Compositional bias | 1881-1896 | Polar residues | |||
Compositional bias | 1903-1922 | Polar residues | |||
Compositional bias | 2809-2823 | Basic and acidic residues | |||
Compositional bias | 2824-2838 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE014134 EMBL· GenBank· DDBJ | AGB92765.2 EMBL· GenBank· DDBJ | Genomic DNA |