M9NF51 · M9NF51_DROME
- Proteinadenylate cyclase
- Generut
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids2055 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- ATP = 3',5'-cyclic AMP + diphosphate
Cofactor
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | adenylate cyclase activity | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Biological Process | cAMP biosynthetic process | |
Biological Process | intracellular signal transduction |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameadenylate cyclase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionM9NF51
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 37-60 | Helical | ||||
Sequence: FSVLGVVALVFVLCGVMAALSLTF | ||||||
Transmembrane | 66-85 | Helical | ||||
Sequence: FHNIFNAIVCGLFAVVLVLL | ||||||
Transmembrane | 97-116 | Helical | ||||
Sequence: TLCYGILLFTASICVVSMPT | ||||||
Transmembrane | 128-147 | Helical | ||||
Sequence: VMAEGVWQIVFVVFLAYAMM | ||||||
Transmembrane | 154-174 | Helical | ||||
Sequence: AVAFGIALPSVHISLTVYKIF | ||||||
Transmembrane | 186-207 | Helical | ||||
Sequence: LIANIVIFIGVNVAGLVVNIMM | ||||||
Transmembrane | 625-647 | Helical | ||||
Sequence: LGFTTAMGCSLLLLILGAALQVT | ||||||
Transmembrane | 653-677 | Helical | ||||
Sequence: LILLLLFLFAFIWVSAILMLLLAVR | ||||||
Transmembrane | 689-707 | Helical | ||||
Sequence: FSLRMAITIFTVILIYSVG | ||||||
Transmembrane | 766-786 | Helical | ||||
Sequence: LLVLGMGTIYGLFIELSHQNI | ||||||
Transmembrane | 798-817 | Helical | ||||
Sequence: IPLHLISLARIAIFMIAILV |
Keywords
- Cellular component
Expression
Gene expression databases
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 275-402 | Guanylate cyclase | ||||
Sequence: SILFADIVGFTVLSSQCSAQELVRLLNELFGRFDQLAHDNHCLRIKILGDCYYCVSGLPEPRKDHAKCAVEMGLDMIDAIATVVEATDVILNMRVGIHTGRVLCGVLGLRKWQFDVWSNDVTLANHME | ||||||
Region | 534-559 | Disordered | ||||
Sequence: GSTCEANSGNVQVSEKGSRKSQSKVA | ||||||
Compositional bias | 536-552 | Polar residues | ||||
Sequence: TCEANSGNVQVSEKGSR | ||||||
Domain | 886-1030 | Guanylate cyclase | ||||
Sequence: GVIFASVPNFNEFYTEMDGSDQGLECLRLLNEIIADFDELLKEDRFRGIDKIKTVGSTYMAVVGLIPEYKIQPNDPNSVRRHMTALIEYVKAMRHSLQEINSHSYNNFMLRVGINIGPVVAGVIGARKPQYDIWGNTVNVASRMD | ||||||
Region | 1140-1222 | Disordered | ||||
Sequence: QHQHKQHDPLPLPAPPPPVHHHLHQQQQQRLNSKLQKQPIFMANGGLPNIRENGNGHNGEHQQQQQQQQQHQQQQQQQQQHGG | ||||||
Compositional bias | 1161-1178 | Polar residues | ||||
Sequence: HLHQQQQQRLNSKLQKQP | ||||||
Compositional bias | 1194-1222 | Polar residues | ||||
Sequence: NGHNGEHQQQQQQQQQHQQQQQQQQQHGG | ||||||
Region | 1284-1337 | Disordered | ||||
Sequence: MPMQHAPKYEPPRYTSPHTMLSQQHQQQQQQQHQHQQPQSQSAQDQQTHPAQDP | ||||||
Compositional bias | 1299-1337 | Polar residues | ||||
Sequence: SPHTMLSQQHQQQQQQQHQHQQPQSQSAQDQQTHPAQDP | ||||||
Region | 1368-1424 | Disordered | ||||
Sequence: KLPTDLEESRDMSSTDDLSSRPHSPSMSSSDESYSKTTEGEGEGDEDSPRMVNGGHL | ||||||
Compositional bias | 1370-1384 | Basic and acidic residues | ||||
Sequence: PTDLEESRDMSSTDD | ||||||
Compositional bias | 1385-1402 | Polar residues | ||||
Sequence: LSSRPHSPSMSSSDESYS | ||||||
Compositional bias | 1403-1421 | Basic and acidic residues | ||||
Sequence: KTTEGEGEGDEDSPRMVNG | ||||||
Region | 1470-1492 | Disordered | ||||
Sequence: STTESQGHHTNSNTTSNTQHKGD | ||||||
Compositional bias | 1546-1627 | Polar residues | ||||
Sequence: STTDQTASNGSRELSYSLSNGKLSSANGHGVGGSGSGSGSGSGSGSAVGNGSGGSGSSNGNLSGGSGSNSNSGNNNSSHHKT | ||||||
Region | 1546-1633 | Disordered | ||||
Sequence: STTDQTASNGSRELSYSLSNGKLSSANGHGVGGSGSGSGSGSGSGSAVGNGSGGSGSSNGNLSGGSGSNSNSGNNNSSHHKTEQQQNM | ||||||
Region | 1709-1864 | Disordered | ||||
Sequence: NGSHAHHGQHHQQPQRTHRQRPRSKELQYSHESLDGLDGAVQSQSQQRHQRYHHHHHHQQRQQQQQRYNHVQEQEERDDTEDNLADEEFEDDEVGRDVRQKRLQKSELNHKRSEVATEAGNHHDDEVEEEDDDDDEEEDHRNGGREAAPLTNGSMR | ||||||
Compositional bias | 1756-1771 | Basic residues | ||||
Sequence: RHQRYHHHHHHQQRQQ | ||||||
Compositional bias | 1786-1801 | Acidic residues | ||||
Sequence: DDTEDNLADEEFEDDE | ||||||
Compositional bias | 1802-1831 | Basic and acidic residues | ||||
Sequence: VGRDVRQKRLQKSELNHKRSEVATEAGNHH | ||||||
Compositional bias | 1832-1847 | Acidic residues | ||||
Sequence: DDEVEEEDDDDDEEED | ||||||
Region | 1884-1919 | Disordered | ||||
Sequence: HQSMDSNPLESQSEWSDDDCREEATGGAESTGYITD | ||||||
Compositional bias | 1997-2046 | Polar residues | ||||
Sequence: SKFGQPLSPAQQQHQQQQQQQQQQQQQHHQQQLQQNPQHTQAQSHLAPVQ | ||||||
Region | 1997-2055 | Disordered | ||||
Sequence: SKFGQPLSPAQQQHQQQQQQQQQQQQQHHQQQLQQNPQHTQAQSHLAPVQFQSAEELRE |
Sequence similarities
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,055
- Mass (Da)228,592
- Last updated2013-06-26 v1
- ChecksumA68CE04583675EA9
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 536-552 | Polar residues | ||||
Sequence: TCEANSGNVQVSEKGSR | ||||||
Compositional bias | 1161-1178 | Polar residues | ||||
Sequence: HLHQQQQQRLNSKLQKQP | ||||||
Compositional bias | 1194-1222 | Polar residues | ||||
Sequence: NGHNGEHQQQQQQQQQHQQQQQQQQQHGG | ||||||
Compositional bias | 1299-1337 | Polar residues | ||||
Sequence: SPHTMLSQQHQQQQQQQHQHQQPQSQSAQDQQTHPAQDP | ||||||
Compositional bias | 1370-1384 | Basic and acidic residues | ||||
Sequence: PTDLEESRDMSSTDD | ||||||
Compositional bias | 1385-1402 | Polar residues | ||||
Sequence: LSSRPHSPSMSSSDESYS | ||||||
Compositional bias | 1403-1421 | Basic and acidic residues | ||||
Sequence: KTTEGEGEGDEDSPRMVNG | ||||||
Compositional bias | 1546-1627 | Polar residues | ||||
Sequence: STTDQTASNGSRELSYSLSNGKLSSANGHGVGGSGSGSGSGSGSGSAVGNGSGGSGSSNGNLSGGSGSNSNSGNNNSSHHKT | ||||||
Compositional bias | 1756-1771 | Basic residues | ||||
Sequence: RHQRYHHHHHHQQRQQ | ||||||
Compositional bias | 1786-1801 | Acidic residues | ||||
Sequence: DDTEDNLADEEFEDDE | ||||||
Compositional bias | 1802-1831 | Basic and acidic residues | ||||
Sequence: VGRDVRQKRLQKSELNHKRSEVATEAGNHH | ||||||
Compositional bias | 1832-1847 | Acidic residues | ||||
Sequence: DDEVEEEDDDDDEEED | ||||||
Compositional bias | 1997-2046 | Polar residues | ||||
Sequence: SKFGQPLSPAQQQHQQQQQQQQQQQQQHHQQQLQQNPQHTQAQSHLAPVQ |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE014298 EMBL· GenBank· DDBJ | AFH07386.1 EMBL· GenBank· DDBJ | Genomic DNA |