M9MSP9 · M9MSP9_DROME

Function

function

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentvoltage-gated sodium channel complex
Molecular Functioncalcium ion binding
Molecular Functionvoltage-gated sodium channel activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Sodium channel protein

Gene names

    • Name
      para
    • Synonyms
      bas
      , bss
      , Dmel\CG9907
      , DmNa[[V]]
      , DmNa[[v]]
      , DmNa[[v]]1
      , DmNav
      , DmNav1
      , l(1)14Da
      , l(1)ESHS48
      , lincRNA.S9469
      , Nav1
      , Ocd
      , olfD
      , par
      , Para
      , sbl
      , sbl-1
      , Shu
      , Shudderer
      , VSSC
    • ORF names
      CG9907
      , Dmel_CG9907

Organism names

  • Taxonomic identifier
  • Strain
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    M9MSP9

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane134-161Helical
Transmembrane205-227Helical
Transmembrane239-257Helical
Transmembrane263-285Helical
Transmembrane395-417Helical
Transmembrane755-778Helical
Transmembrane799-816Helical
Transmembrane828-852Helical
Transmembrane883-905Helical
Transmembrane963-984Helical
Transmembrane1272-1294Helical
Transmembrane1300-1326Helical
Transmembrane1347-1378Helical
Transmembrane1465-1491Helical
Transmembrane1554-1572Helical
Transmembrane1584-1603Helical
Transmembrane1615-1634Helical
Transmembrane1678-1701Helical
Transmembrane1764-1787Helical

Keywords

PTM/Processing

Keywords

Expression

Gene expression databases

Structure

3D structure databases

Family & Domains

Features

Showing features for compositional bias, region, coiled coil, domain.

TypeIDPosition(s)Description
Compositional bias35-51Basic and acidic residues
Region35-74Disordered
Coiled coil421-471
Region615-635Disordered
Compositional bias1097-1111Basic and acidic residues
Region1097-1171Disordered
Compositional bias1112-1126Polar residues
Compositional bias1127-1156Basic and acidic residues
Compositional bias1157-1171Acidic residues
Domain1808-1843EF-hand
Compositional bias1932-1955Basic and acidic residues
Region1932-2027Disordered

Sequence similarities

Belongs to the sodium channel (TC 1.A.1.10) family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,062
  • Mass (Da)
    231,550
  • Last updated
    2013-06-26 v1
  • Checksum
    43C3A192EF72694E
MTEDSDSISEEERSLFRPFTRESLVQIEQRIAAEHEKQKELERKRAEGEVIRYDDEDEDEGPQPDPTLEQGVPIPVRLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSASKAMWMLDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTEVIFTGIYTFESAVKVMARGFILCPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGSWGNLTDENWDYHNRNSSNWYSEDEGISFPLCGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSFGWAFLSAFRLMTQDFWEDLYQLVLRAAGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEEAIREAEEAAAAKAAKLEERANAQAQAAADAAAAEEAALHPEMAKSPTYSCISYELFVGGEKGNDDNNKEKMSIRSVEVESESYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEENGAIIVPVYYGNLGSRHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRNQSVGATNGGTTCLDTNHKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVLNDIIEQAAGRHSRASDRGVSVYYFPTEDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDPFVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWNIFDFIIVALSLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYHDHKDRFPDGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCMYVGDVSCIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSAPTADNDTNKIAEAFNRIGRFKSWVKRNIADCFKLIRNKLTNQISDQPSGKGVCRCISAEHGDNELELGHDEILADGLIKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYLNNATDDDTASINSYGSHKNRPFKDESHKGSAETMEGEEKRDASKEDLGLDEELDEEGECEEGPLDGDIIIHAHDEDILDEYPADCCPDSYYKKFPILAGDDDSPFWQGWGNLRLKTFQLIENKYFETAVITMILMSSLALALEDVHLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALGFKVYFTNAWCWLDFVIVMVSLINFVASLVGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCEDMNGTKLSHEIIPNRNACESENYTWVNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALRYHYFIEPWNLFDVVVVILSILGLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKEKSGINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIINEEACDPPDNDKGYPGNCGSATVGITFLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHKPNKYKIISMDIPICRGDLMYCVDILDALTKDFFARKGNPIEETGEIGEIAARPDTEGYEPVSSTLWRQREEYCARLIQHAWRKHKARGEGGGSFEPDTDHGDGGDPDAGDPAPDEATDGDAPAGGDGSVNGTAEGAADADESNVNSPGEDAAAAAAAAAAAAAAGTTTAGSPGAGSAGRQTAVLVESDGFVTKNGHKVVIHSRSPSITSRTADV

Computationally mapped potential isoform sequences

There are 55 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
P35500SCNA_DROMEpara2131
X2JKQ0X2JKQ0_DROMEpara2131
X2JFE8X2JFE8_DROMEpara2055
M9MSC3M9MSC3_DROMEpara2076
M9MSC7M9MSC7_DROMEpara2097
M9MSD2M9MSD2_DROMEpara2110
M9MSD5M9MSD5_DROMEpara2108
M9MSD6M9MSD6_DROMEpara2097
M9MSD7M9MSD7_DROMEpara2076
M9MSD8M9MSD8_DROMEpara2121
M9MSD9M9MSD9_DROMEpara1125
M9MSE0M9MSE0_DROMEpara2118
M9MSE1M9MSE1_DROMEpara2111
M9MSE2M9MSE2_DROMEpara2089
M9MSE3M9MSE3_DROMEpara917
M9MSE4M9MSE4_DROMEpara2108
M9MSE6M9MSE6_DROMEpara2132
M9MSE7M9MSE7_DROMEpara2113
M9MSE9M9MSE9_DROMEpara2056
M9MSF1M9MSF1_DROMEpara2132
M9MSF2M9MSF2_DROMEpara2056
M9MSP6M9MSP6_DROMEpara2107
M9MSQ0M9MSQ0_DROMEpara2066
M9MSP1M9MSP1_DROMEpara2079
M9MSP2M9MSP2_DROMEpara2100
M9MSP3M9MSP3_DROMEpara2100
M9MSP4M9MSP4_DROMEpara2125
M9MSP5M9MSP5_DROMEpara2084
M9MSP7M9MSP7_DROMEpara2083
M9MSP8M9MSP8_DROMEpara240
M9MS71M9MS71_DROMEpara2092
M9MS73M9MS73_DROMEpara2079
M9MS75M9MS75_DROMEpara2110
M9MS78M9MS78_DROMEpara2102
M9MS79M9MS79_DROMEpara2138
M9MS83M9MS83_DROMEpara2086
M9MS84M9MS84_DROMEpara2086
M9MS87M9MS87_DROMEpara2089
M9MS88M9MS88_DROMEpara2086
M9MS95M9MS95_DROMEpara2089
M9MS96M9MS96_DROMEpara2067
M9MS61M9MS61_DROMEpara2108
M9MS65M9MS65_DROMEpara2100
M9MS66M9MS66_DROMEpara2097
M9MS69M9MS69_DROMEpara2100
M9MS91M9MS91_DROMEpara2111
M9MS92M9MS92_DROMEpara2143
M9MS99M9MS99_DROMEpara1117
M9MSA0M9MSA0_DROMEpara2099
M9MSA3M9MSA3_DROMEpara2132
M9MSA4M9MSA4_DROMEpara872
M9MSB4M9MSB4_DROMEpara2087
M9MSB8M9MSB8_DROMEpara2087
M9PJP5M9PJP5_DROMEpara2145
B7Z0Z2B7Z0Z2_DROMEpara2114

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias35-51Basic and acidic residues
Compositional bias1097-1111Basic and acidic residues
Compositional bias1112-1126Polar residues
Compositional bias1127-1156Basic and acidic residues
Compositional bias1157-1171Acidic residues
Compositional bias1932-1955Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE014298
EMBL· GenBank· DDBJ
ADV37726.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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