M9MS75 · M9MS75_DROME
- ProteinSodium channel protein
- Genepara
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids2110 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | voltage-gated sodium channel complex | |
Molecular Function | calcium ion binding | |
Molecular Function | voltage-gated sodium channel activity |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameSodium channel protein
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionM9MS75
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 145-172 | Helical | ||||
Sequence: VAIYILVHPLFSLFIITTILVNCILMIM | ||||||
Transmembrane | 216-238 | Helical | ||||
Sequence: WLDFVVIALAYVTMGIDLGNLAA | ||||||
Transmembrane | 250-268 | Helical | ||||
Sequence: TVAIVPGLKTIVGAVIESV | ||||||
Transmembrane | 274-296 | Helical | ||||
Sequence: VIILTMFSLSVFALMGLQIYMGV | ||||||
Transmembrane | 406-428 | Helical | ||||
Sequence: MLFFIVIIFLGSFYLVNLILAIV | ||||||
Transmembrane | 803-826 | Helical | ||||
Sequence: VSLIVFDPFVELFITLCIVVNTMF | ||||||
Transmembrane | 847-864 | Helical | ||||
Sequence: YFFTATFAIEATMKLMAM | ||||||
Transmembrane | 876-900 | Helical | ||||
Sequence: IFDFIIVALSLLELGLEGVQGLSVL | ||||||
Transmembrane | 931-953 | Helical | ||||
Sequence: ALGNLTFVLCIIIFIFAVMGMQL | ||||||
Transmembrane | 1011-1032 | Helical | ||||
Sequence: FFLATVVIGNLVVLNLFLALLL | ||||||
Transmembrane | 1320-1342 | Helical | ||||
Sequence: IFTVIFFLEMLIKWLALGFKVYF | ||||||
Transmembrane | 1348-1374 | Helical | ||||
Sequence: WLDFVIVMVSLINFVASLVGAGGIQAF | ||||||
Transmembrane | 1395-1426 | Helical | ||||
Sequence: MRVVVNALVQAIPSIFNVLLVCLIFWLIFAIM | ||||||
Transmembrane | 1513-1539 | Helical | ||||
Sequence: IYMYLYFVFFIIFGSFFTLNLFIGVII | ||||||
Transmembrane | 1602-1620 | Helical | ||||
Sequence: IIIMLFIGLNMFTMTLDRY | ||||||
Transmembrane | 1632-1651 | Helical | ||||
Sequence: YLNAIFVVIFSSECLLKIFA | ||||||
Transmembrane | 1663-1682 | Helical | ||||
Sequence: LFDVVVVILSILGLVLSDII | ||||||
Transmembrane | 1726-1749 | Helical | ||||
Sequence: ALFNICLLLFLVMFIFAIFGMSFF | ||||||
Transmembrane | 1812-1835 | Helical | ||||
Sequence: ATVGITFLLSYLVISFLIVINMYI |
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Expression
Gene expression databases
Family & Domains
Features
Showing features for compositional bias, region, coiled coil, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 35-65 | Basic and acidic residues | ||||
Sequence: HEKQKELERKRAEGEVPQYGRKKKQKEIRYD | ||||||
Region | 35-84 | Disordered | ||||
Sequence: HEKQKELERKRAEGEVPQYGRKKKQKEIRYDDEDEDEGPQPDPTLEQGVP | ||||||
Coiled coil | 432-482 | |||||
Sequence: YDELQKKAEEEEAAEEEAIREAEEAAAAKAAKLEERANAQAQAAADAAAAE | ||||||
Compositional bias | 553-571 | Polar residues | ||||
Sequence: STTSLSLPGSPFNIRRGSR | ||||||
Region | 553-572 | Disordered | ||||
Sequence: STTSLSLPGSPFNIRRGSRS | ||||||
Region | 671-691 | Disordered | ||||
Sequence: KESKLRNRNTRNQSVGATNGG | ||||||
Compositional bias | 1145-1159 | Basic and acidic residues | ||||
Sequence: DMKNNKPKKSKYLNN | ||||||
Region | 1145-1219 | Disordered | ||||
Sequence: DMKNNKPKKSKYLNNATDDDTASINSYGSHKNRPFKDESHKGSAETMEGEEKRDASKEDLGLDEELDEEGECEEG | ||||||
Compositional bias | 1160-1174 | Polar residues | ||||
Sequence: ATDDDTASINSYGSH | ||||||
Compositional bias | 1175-1204 | Basic and acidic residues | ||||
Sequence: KNRPFKDESHKGSAETMEGEEKRDASKEDL | ||||||
Compositional bias | 1205-1219 | Acidic residues | ||||
Sequence: GLDEELDEEGECEEG | ||||||
Domain | 1856-1891 | EF-hand | ||||
Sequence: DDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPP | ||||||
Compositional bias | 1980-2003 | Basic and acidic residues | ||||
Sequence: HKARGEGGGSFEPDTDHGDGGDPD | ||||||
Region | 1980-2075 | Disordered | ||||
Sequence: HKARGEGGGSFEPDTDHGDGGDPDAGDPAPDEATDGDAPAGGDGSVNGTAEGAADADESNVNSPGEDAAAAAAAAAAAAAAGTTTAGSPGAGSAGR |
Sequence similarities
Belongs to the sodium channel (TC 1.A.1.10) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,110
- Mass (Da)236,817
- Last updated2013-06-26 v1
- Checksum4A1F05C08F8EAD0A
Computationally mapped potential isoform sequences
There are 55 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
P35500 | SCNA_DROME | para | 2131 | ||
X2JKQ0 | X2JKQ0_DROME | para | 2131 | ||
X2JFE8 | X2JFE8_DROME | para | 2055 | ||
M9MSC3 | M9MSC3_DROME | para | 2076 | ||
M9MSC7 | M9MSC7_DROME | para | 2097 | ||
M9MSD2 | M9MSD2_DROME | para | 2110 | ||
M9MSD5 | M9MSD5_DROME | para | 2108 | ||
M9MSD6 | M9MSD6_DROME | para | 2097 | ||
M9MSD7 | M9MSD7_DROME | para | 2076 | ||
M9MSD8 | M9MSD8_DROME | para | 2121 | ||
M9MSD9 | M9MSD9_DROME | para | 1125 | ||
M9MSE0 | M9MSE0_DROME | para | 2118 | ||
M9MSE1 | M9MSE1_DROME | para | 2111 | ||
M9MSE2 | M9MSE2_DROME | para | 2089 | ||
M9MSE3 | M9MSE3_DROME | para | 917 | ||
M9MSE4 | M9MSE4_DROME | para | 2108 | ||
M9MSE6 | M9MSE6_DROME | para | 2132 | ||
M9MSE7 | M9MSE7_DROME | para | 2113 | ||
M9MSE9 | M9MSE9_DROME | para | 2056 | ||
M9MSF1 | M9MSF1_DROME | para | 2132 | ||
M9MSF2 | M9MSF2_DROME | para | 2056 | ||
M9MSP6 | M9MSP6_DROME | para | 2107 | ||
M9MSQ0 | M9MSQ0_DROME | para | 2066 | ||
M9MSP1 | M9MSP1_DROME | para | 2079 | ||
M9MSP2 | M9MSP2_DROME | para | 2100 | ||
M9MSP3 | M9MSP3_DROME | para | 2100 | ||
M9MSP4 | M9MSP4_DROME | para | 2125 | ||
M9MSP5 | M9MSP5_DROME | para | 2084 | ||
M9MSP7 | M9MSP7_DROME | para | 2083 | ||
M9MSP8 | M9MSP8_DROME | para | 240 | ||
M9MSP9 | M9MSP9_DROME | para | 2062 | ||
M9MS71 | M9MS71_DROME | para | 2092 | ||
M9MS73 | M9MS73_DROME | para | 2079 | ||
M9MS78 | M9MS78_DROME | para | 2102 | ||
M9MS79 | M9MS79_DROME | para | 2138 | ||
M9MS83 | M9MS83_DROME | para | 2086 | ||
M9MS84 | M9MS84_DROME | para | 2086 | ||
M9MS87 | M9MS87_DROME | para | 2089 | ||
M9MS88 | M9MS88_DROME | para | 2086 | ||
M9MS95 | M9MS95_DROME | para | 2089 | ||
M9MS96 | M9MS96_DROME | para | 2067 | ||
M9MS61 | M9MS61_DROME | para | 2108 | ||
M9MS65 | M9MS65_DROME | para | 2100 | ||
M9MS66 | M9MS66_DROME | para | 2097 | ||
M9MS69 | M9MS69_DROME | para | 2100 | ||
M9MS91 | M9MS91_DROME | para | 2111 | ||
M9MS92 | M9MS92_DROME | para | 2143 | ||
M9MS99 | M9MS99_DROME | para | 1117 | ||
M9MSA0 | M9MSA0_DROME | para | 2099 | ||
M9MSA3 | M9MSA3_DROME | para | 2132 | ||
M9MSA4 | M9MSA4_DROME | para | 872 | ||
M9MSB4 | M9MSB4_DROME | para | 2087 | ||
M9MSB8 | M9MSB8_DROME | para | 2087 | ||
M9PJP5 | M9PJP5_DROME | para | 2145 | ||
B7Z0Z2 | B7Z0Z2_DROME | para | 2114 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 35-65 | Basic and acidic residues | ||||
Sequence: HEKQKELERKRAEGEVPQYGRKKKQKEIRYD | ||||||
Compositional bias | 553-571 | Polar residues | ||||
Sequence: STTSLSLPGSPFNIRRGSR | ||||||
Compositional bias | 1145-1159 | Basic and acidic residues | ||||
Sequence: DMKNNKPKKSKYLNN | ||||||
Compositional bias | 1160-1174 | Polar residues | ||||
Sequence: ATDDDTASINSYGSH | ||||||
Compositional bias | 1175-1204 | Basic and acidic residues | ||||
Sequence: KNRPFKDESHKGSAETMEGEEKRDASKEDL | ||||||
Compositional bias | 1205-1219 | Acidic residues | ||||
Sequence: GLDEELDEEGECEEG | ||||||
Compositional bias | 1980-2003 | Basic and acidic residues | ||||
Sequence: HKARGEGGGSFEPDTDHGDGGDPD |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE014298 EMBL· GenBank· DDBJ | ADV37697.1 EMBL· GenBank· DDBJ | Genomic DNA |