M9MS75 · M9MS75_DROME

Function

function

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentvoltage-gated sodium channel complex
Molecular Functioncalcium ion binding
Molecular Functionvoltage-gated sodium channel activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Sodium channel protein

Gene names

    • Name
      para
    • Synonyms
      bas
      , bss
      , Dmel\CG9907
      , DmNa[[V]]
      , DmNa[[v]]
      , DmNa[[v]]1
      , DmNav
      , DmNav1
      , l(1)14Da
      , l(1)ESHS48
      , lincRNA.S9469
      , Nav1
      , Ocd
      , olfD
      , par
      , Para
      , sbl
      , sbl-1
      , Shu
      , Shudderer
      , VSSC
    • ORF names
      CG9907
      , Dmel_CG9907

Organism names

  • Taxonomic identifier
  • Strain
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    M9MS75

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane145-172Helical
Transmembrane216-238Helical
Transmembrane250-268Helical
Transmembrane274-296Helical
Transmembrane406-428Helical
Transmembrane803-826Helical
Transmembrane847-864Helical
Transmembrane876-900Helical
Transmembrane931-953Helical
Transmembrane1011-1032Helical
Transmembrane1320-1342Helical
Transmembrane1348-1374Helical
Transmembrane1395-1426Helical
Transmembrane1513-1539Helical
Transmembrane1602-1620Helical
Transmembrane1632-1651Helical
Transmembrane1663-1682Helical
Transmembrane1726-1749Helical
Transmembrane1812-1835Helical

Keywords

PTM/Processing

Keywords

Expression

Gene expression databases

Structure

3D structure databases

Family & Domains

Features

Showing features for compositional bias, region, coiled coil, domain.

TypeIDPosition(s)Description
Compositional bias35-65Basic and acidic residues
Region35-84Disordered
Coiled coil432-482
Compositional bias553-571Polar residues
Region553-572Disordered
Region671-691Disordered
Compositional bias1145-1159Basic and acidic residues
Region1145-1219Disordered
Compositional bias1160-1174Polar residues
Compositional bias1175-1204Basic and acidic residues
Compositional bias1205-1219Acidic residues
Domain1856-1891EF-hand
Compositional bias1980-2003Basic and acidic residues
Region1980-2075Disordered

Sequence similarities

Belongs to the sodium channel (TC 1.A.1.10) family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,110
  • Mass (Da)
    236,817
  • Last updated
    2013-06-26 v1
  • Checksum
    4A1F05C08F8EAD0A
MTEDSDSISEEERSLFRPFTRESLVQIEQRIAAEHEKQKELERKRAEGEVPQYGRKKKQKEIRYDDEDEDEGPQPDPTLEQGVPIPVRLQGSFPPELASTPLEDIDPYYSNVLTFVVVSKGKDIFRFSASKAMWMLDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTEVIFTGIYTFESAVKVMARGFILCPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGSWGNLTDENWDYHNRNSSNWYSEDEGISFPLCGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSFGWAFLSAFRLMTQDFWEDLYQLVLRAAGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEEAIREAEEAAAAKAAKLEERANAQAQAAADAAAAEEAALHPEMAKSPTYSCISYELFVGGEKGNDDNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATKVRKVSTTSLSLPGSPFNIRRGSRSSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSEENGAIIVPVYYGNLGSRHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRNQSVGATNGGTTCLDTNHKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVLNDIIEQAAGRHSRASDRGEDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWVSLIVFDPFVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSPKYYFQEGWNIFDFIIVALSLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYHDHKDRFPDGDLPRWNFTDFMHSFMIVFRVLCGEWIESMWDCMYVGDVSCIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSAPTADNDTNKIAEAFNRIGRFKSWVKRNIADCFKLIRNKLTNQISDQPSGKGVCRCISAEHGDNELELGHDEILADGLIKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYLNNATDDDTASINSYGSHKNRPFKDESHKGSAETMEGEEKRDASKEDLGLDEELDEEGECEEGPLDGDIIIHAHDEDILDEYPADCCPDSYYKKFPILAGDDDSPFWQGWGNLRLKTFQLIENKYFETAVITMILMSSLALALEDVHLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALGFKVYFTNAWCWLDFVIVMVSLINFVASLVGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCEDMNGTKLSHEIIPNRNACESENYTWVNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALRYHYFIEPWNLFDVVVVILSILGLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKEKSGINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIINEEACDPPDNDKGYPGNCGSATVGITFLLSYLVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHKPNKYKIISMDIPICRGDLMYCVDILDALTKDFFARKGNPIEETGEIGEIAARPDTEGYEPVSSTLWRQREEYCARLIQHAWRKHKARGEGGGSFEPDTDHGDGGDPDAGDPAPDEATDGDAPAGGDGSVNGTAEGAADADESNVNSPGEDAAAAAAAAAAAAAAGTTTAGSPGAGSAGRQTAVLVESDGFVTKNGHKVVIHSRSPSITSRTADV

Computationally mapped potential isoform sequences

There are 55 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
P35500SCNA_DROMEpara2131
X2JKQ0X2JKQ0_DROMEpara2131
X2JFE8X2JFE8_DROMEpara2055
M9MSC3M9MSC3_DROMEpara2076
M9MSC7M9MSC7_DROMEpara2097
M9MSD2M9MSD2_DROMEpara2110
M9MSD5M9MSD5_DROMEpara2108
M9MSD6M9MSD6_DROMEpara2097
M9MSD7M9MSD7_DROMEpara2076
M9MSD8M9MSD8_DROMEpara2121
M9MSD9M9MSD9_DROMEpara1125
M9MSE0M9MSE0_DROMEpara2118
M9MSE1M9MSE1_DROMEpara2111
M9MSE2M9MSE2_DROMEpara2089
M9MSE3M9MSE3_DROMEpara917
M9MSE4M9MSE4_DROMEpara2108
M9MSE6M9MSE6_DROMEpara2132
M9MSE7M9MSE7_DROMEpara2113
M9MSE9M9MSE9_DROMEpara2056
M9MSF1M9MSF1_DROMEpara2132
M9MSF2M9MSF2_DROMEpara2056
M9MSP6M9MSP6_DROMEpara2107
M9MSQ0M9MSQ0_DROMEpara2066
M9MSP1M9MSP1_DROMEpara2079
M9MSP2M9MSP2_DROMEpara2100
M9MSP3M9MSP3_DROMEpara2100
M9MSP4M9MSP4_DROMEpara2125
M9MSP5M9MSP5_DROMEpara2084
M9MSP7M9MSP7_DROMEpara2083
M9MSP8M9MSP8_DROMEpara240
M9MSP9M9MSP9_DROMEpara2062
M9MS71M9MS71_DROMEpara2092
M9MS73M9MS73_DROMEpara2079
M9MS78M9MS78_DROMEpara2102
M9MS79M9MS79_DROMEpara2138
M9MS83M9MS83_DROMEpara2086
M9MS84M9MS84_DROMEpara2086
M9MS87M9MS87_DROMEpara2089
M9MS88M9MS88_DROMEpara2086
M9MS95M9MS95_DROMEpara2089
M9MS96M9MS96_DROMEpara2067
M9MS61M9MS61_DROMEpara2108
M9MS65M9MS65_DROMEpara2100
M9MS66M9MS66_DROMEpara2097
M9MS69M9MS69_DROMEpara2100
M9MS91M9MS91_DROMEpara2111
M9MS92M9MS92_DROMEpara2143
M9MS99M9MS99_DROMEpara1117
M9MSA0M9MSA0_DROMEpara2099
M9MSA3M9MSA3_DROMEpara2132
M9MSA4M9MSA4_DROMEpara872
M9MSB4M9MSB4_DROMEpara2087
M9MSB8M9MSB8_DROMEpara2087
M9PJP5M9PJP5_DROMEpara2145
B7Z0Z2B7Z0Z2_DROMEpara2114

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias35-65Basic and acidic residues
Compositional bias553-571Polar residues
Compositional bias1145-1159Basic and acidic residues
Compositional bias1160-1174Polar residues
Compositional bias1175-1204Basic and acidic residues
Compositional bias1205-1219Acidic residues
Compositional bias1980-2003Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE014298
EMBL· GenBank· DDBJ
ADV37697.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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