M7XFW1 · M7XFW1_RHOT1

Function

function

Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.

Catalytic activity

Cofactor

a monovalent cation (UniProtKB | Rhea| CHEBI:60242 )

Note: A monovalent cation.

Pathway

Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site99Mg2+ 1 (UniProtKB | ChEBI)
Binding site173Mg2+ 1 (UniProtKB | ChEBI)
Binding site201Mg2+ 1 (UniProtKB | ChEBI)
Binding site342ATP (UniProtKB | ChEBI)
Binding site361ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentmitochondrial inner membrane
Cellular Componentmitochondrial matrix
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functiontetrahydrofolylpolyglutamate synthase activity
Biological Processone-carbon metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Folylpolyglutamate synthase
  • EC number
  • Alternative names
    • Folylpoly-gamma-glutamate synthetase
    • Tetrahydrofolylpolyglutamate synthase

Gene names

    • ORF names
      RHTO_05405

Organism names

Accessions

  • Primary accession
    M7XFW1

Proteomes

Subcellular Location

Keywords

Family & Domains

Sequence similarities

Belongs to the folylpolyglutamate synthase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    531
  • Mass (Da)
    56,446
  • Last updated
    2013-05-29 v1
  • Checksum
    0CD2AF5F09E89525
MSSAASTARSYAAAIDALNGLQSNAQVIDAIRKSGGKGGDVQLREQVEYMRRIGYEAADLNRMNVLHITGTKGKGSTSAFVSSILTTLAPKAKVGLYTSPHMVAVRERIRINGEPIAEDVFARYFWEVWDRLEQADKPAADEATPEKPAYFRYLTIMAMHVFLSERVDATILEVGVGGTYDSTNIVPQPITTGVTALGIDHIWVLGKTWPEIAAQKGGIYKPGVPALAIQQPEGLDVLESRAKELGASSFTVVPEHPQLKAIKLGLAGSFQRSNASLAIALVQSFLSSSRCPPAFRSLAPASSAPSSTSSASLPSLPSSLIAPTPLPSALQKGLENARWPGRCQTESDPLLGGEKVKWFLDGAHTVESLRCCGEWFRDDALAPTSSSENTPTRFLIFNCTSGRSGSELLSSLLSALAPPPSSELAQPFDHVVFCTNTTFASGDSKGDLTSNAVDASDLAALQTQHDLASAFSTLVSSSSSSLKKAEIHVLSSIQEAVELVRQEGEKRRVEALVTGSLHLVGGVMAVAELPL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KB722673
EMBL· GenBank· DDBJ
EMS19033.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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