M7X3Z4 · M7X3Z4_RHOT1
- Protein6-phosphogluconate dehydrogenase, decarboxylating
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids476 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.
Catalytic activity
- 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH
Pathway
Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 90 | substrate; ligand shared between dimeric partners; in other chain | |||
Binding site | 116-118 | substrate; ligand shared between dimeric partners; in other chain | |||
Active site | 170 | Proton acceptor | |||
Binding site | 173-174 | substrate; ligand shared between dimeric partners; in other chain | |||
Active site | 177 | Proton donor | |||
Binding site | 178 | substrate; ligand shared between dimeric partners; in other chain | |||
Binding site | 247 | substrate; ligand shared between dimeric partners; in other chain | |||
Binding site | 274 | substrate; ligand shared between dimeric partners; in other chain | |||
Binding site | 433 | substrate; ligand shared between dimeric partners | |||
Binding site | 439 | substrate; ligand shared between dimeric partners | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | NADP binding | |
Molecular Function | phosphogluconate dehydrogenase (decarboxylating) activity | |
Biological Process | D-gluconate metabolic process | |
Biological Process | pentose-phosphate shunt |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name6-phosphogluconate dehydrogenase, decarboxylating
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Basidiomycota > Pucciniomycotina > Microbotryomycetes > Sporidiobolales > Sporidiobolaceae > Rhodotorula
Accessions
- Primary accessionM7X3Z4
Proteomes
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 166-463 | 6-phosphogluconate dehydrogenase C-terminal | |||
Sequence similarities
Belongs to the 6-phosphogluconate dehydrogenase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length476
- Mass (Da)52,470
- Last updated2013-05-29 v1
- MD5 Checksum73F74C6B641EA7F9CE833F2A8B39E4F5
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KB722643 EMBL· GenBank· DDBJ | EMS25061.1 EMBL· GenBank· DDBJ | Genomic DNA |