M7WLV7 · M7WLV7_RHOT1

Function

function

Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.

Catalytic activity

Pathway

Lipid metabolism; fatty acid biosynthesis.

Features

Showing features for binding site, active site.

133950100150200250300
Type
IDPosition(s)Description
Binding site200substrate
Active site213Proton acceptor

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functionketoreductase activity
Molecular Functionvery-long-chain 3-oxoacyl-CoA reductase activity
Biological Processfatty acid elongation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Very-long-chain 3-oxoacyl-CoA reductase
  • EC number
  • Alternative names
    • 3-ketoacyl-CoA reductase
      (3-ketoreductase
      ; KAR
      )
    • Microsomal beta-keto-reductase

Gene names

    • ORF names
      RHTO_05562

Organism names

Accessions

  • Primary accession
    M7WLV7

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
; Single-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane22-44Helical

Keywords

Family & Domains

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    339
  • Mass (Da)
    36,818
  • Last updated
    2013-05-29 v1
  • MD5 Checksum
    0E593DB97898C8D9A911D547DD0B18C4
MDVATLRAQAIDWASDCPLTTLAFAVLGAGWLGSYVLSFARMAVDLARPGIPLKRFGAKKGAWAVVTGATAGIGRDFALQLAAAGFNIFLASRTASKLDEIAQEITAKYPSVKTQVHAIDFSSASADYAALKAALDPLDVGVLINNVGKSYEEPTFFQDLSDQDMIDIVEINVNATMKVTKLVVPGMVSRKRGLILTVGSFASLIPSPLLAVYSGSKAFLSTWSQALGSELQGTGVEVELLNTYFVVSKLSKIRKSSWMIPTPKTYVRSVLSHIGVRGGAVGQPHISTPYHGHAPVQWVVDHLFSRQFWLDYNRKLHLDIRKRALRKREREAAKAVKGE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KB722675
EMBL· GenBank· DDBJ
EMS18815.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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