M7WKZ4 · M7WKZ4_RHOT1

Function

function

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

K+ (UniProtKB | Rhea| CHEBI:29103 )

Activity regulation

Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

Pathway

Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site278-280NAD+ (UniProtKB | ChEBI)
Binding site328-330NAD+ (UniProtKB | ChEBI)
Binding site330K+ (UniProtKB | ChEBI); ligand shared between two tetrameric partners; in other chain
Binding site332K+ (UniProtKB | ChEBI); ligand shared between two tetrameric partners; in other chain
Binding site333IMP (UniProtKB | ChEBI)
Active site335Thioimidate intermediate
Binding site335K+ (UniProtKB | ChEBI); ligand shared between two tetrameric partners; in other chain
Binding site368-370IMP (UniProtKB | ChEBI)
Binding site391-392IMP (UniProtKB | ChEBI)
Binding site415-419IMP (UniProtKB | ChEBI)
Active site445Proton acceptor
Binding site457IMP (UniProtKB | ChEBI)
Binding site512K+ (UniProtKB | ChEBI); ligand shared between two tetrameric partners

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionIMP dehydrogenase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Biological ProcessGMP biosynthetic process
Biological ProcessGTP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Inosine-5'-monophosphate dehydrogenase
  • EC number
  • Short names
    IMP dehydrogenase
    ; IMPD
    ; IMPDH

Gene names

    • ORF names
      RHTO_05912

Organism names

Accessions

  • Primary accession
    M7WKZ4

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain120-180CBS
Domain182-240CBS

Sequence similarities

Belongs to the IMPDH/GMPR family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    531
  • Mass (Da)
    56,894
  • Last updated
    2013-05-29 v1
  • Checksum
    B1C982E669A5544A
MPFLDPKNALAHLELYSRGDGLSVRELMDSQKQGGLTYNDFLVLPGHIDFPASAVSLESRVTKKTVIKTPFLSSPMDTVTETDMAIAMALLGGLGVIHHNLPPQMQADMVRAVKKFENGFITDPICLTPKNTVADVWAIKEKHGFCGIPITDSGKLGGKLLGIVTGRDIQFRPNSASLESVMTQGADLVTGPAGITLEQANDILRDSKKGKLPLVDKEGRLVALLARSDLLKNKDYPLASKKPDSKQLICAAAIGTRAPDRDRLRLLVEAGLDVVVLDSSQGNSVYQIEMIQWIKQEFPDLEVIAGNVVTREQAASLIHAGADGLRVGMGSGSICITQEVTAVGRPQATAVFAVAEFARQFGVPVIADGGISNVGHIAKALALGASAVMMGGLLAGTTESPGEYFYNEGKRLKKYRGMGSIDAMDAGTVKDHKKADEIDNAATSRYFSEGDAVRVAQGVAGAVQDKGSLRKFIPYLFAGLQHSLQDMGTRSIAEMQDASFDNTLRFELRTASAQLEGGVHGLHSYEKRLFS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KB722679
EMBL· GenBank· DDBJ
EMS18515.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp