M7U519 · M7U519_BOTF1
- ProteinHistone-lysine N-methyltransferase, H3 lysine-4 specific
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1265 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
function
Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. Binds RNAs which might negatively affect its histone methyltransferase activity. COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face.
Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face.
Catalytic activity
- L-lysyl4-[histone H3] + 3 S-adenosyl-L-methionine = N6,N6,N6-trimethyl-L-lysyl4-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H+
- N6,N6-dimethyl-L-lysyl4-[histone H3] + S-adenosyl-L-methionine = N6,N6,N6-trimethyl-L-lysyl4-[histone H3] + S-adenosyl-L-homocysteine + H+
- N6-methyl-L-lysyl4-[histone H3] + S-adenosyl-L-methionine = N6,N6-dimethyl-L-lysyl4-[histone H3] + S-adenosyl-L-homocysteine + H+
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | chromosome | |
Cellular Component | Set1C/COMPASS complex | |
Molecular Function | histone H3K4 trimethyltransferase activity | |
Biological Process | methylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHistone-lysine N-methyltransferase, H3 lysine-4 specific
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Leotiomycetes > Helotiales > Sclerotiniaceae > Botrytis
Accessions
- Primary accessionM7U519
Proteomes
Subcellular Location
Interaction
Subunit
Component of the COMPASS (Set1C) complex.
Component of the Set1C/COMPASS complex.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-48 | Disordered | |||
Compositional bias | 19-33 | Basic and acidic residues | |||
Compositional bias | 34-48 | Polar residues | |||
Compositional bias | 86-140 | Polar residues | |||
Region | 86-149 | Disordered | |||
Region | 194-221 | Disordered | |||
Region | 385-428 | Disordered | |||
Compositional bias | 390-422 | Pro residues | |||
Region | 548-596 | Disordered | |||
Compositional bias | 557-596 | Basic and acidic residues | |||
Region | 651-683 | Disordered | |||
Compositional bias | 728-765 | Basic and acidic residues | |||
Region | 728-810 | Disordered | |||
Compositional bias | 772-789 | Basic and acidic residues | |||
Domain | 1123-1240 | SET | |||
Domain | 1249-1265 | Post-SET | |||
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,265
- Mass (Da)141,277
- Last updated2013-05-29 v1
- Checksum6A1ECD15B97264C7
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 19-33 | Basic and acidic residues | |||
Compositional bias | 34-48 | Polar residues | |||
Compositional bias | 86-140 | Polar residues | |||
Compositional bias | 390-422 | Pro residues | |||
Compositional bias | 557-596 | Basic and acidic residues | |||
Compositional bias | 728-765 | Basic and acidic residues | |||
Compositional bias | 772-789 | Basic and acidic residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KB707681 EMBL· GenBank· DDBJ | EMR90981.1 EMBL· GenBank· DDBJ | Genomic DNA |