M7CBA6 · M7CBA6_CHEMY

Function

Catalytic activity

  • neurotensin + H2O = neurotensin(1-11) + L-isoleucyl-L-leucine
    This reaction proceeds in the forward direction.
  • neurotensin + H2O = neurotensin(1-10) + L-tyrosyl-L-isoleucyl-L-leucine
    This reaction proceeds in the forward direction.
  • substance P + H2O = substance P(1-9) + L-Leu-L-Met-NH2
    This reaction proceeds in the forward direction.
  • substance P + H2O = substance P(1-7) + L-Phe-Gly-L-Leu-L-Met-NH2
    This reaction proceeds in the forward direction.
  • Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1'.
    EC:3.4.24.11 (UniProtKB | ENZYME | Rhea)

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionmetal ion binding
Molecular Functionmetalloendopeptidase activity
Biological Processamyloid-beta clearance
Biological Processprotein processing

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Neprilysin
  • EC number
  • Alternative names
    • Atriopeptidase
    • Enkephalinase
    • Neutral endopeptidase 24.11
    • Skin fibroblast elastase

Gene names

    • ORF names
      UY3_04730

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Testudinata > Testudines > Cryptodira > Durocryptodira > Americhelydia > Chelonioidea > Cheloniidae > Chelonia

Accessions

  • Primary accession
    M7CBA6

Proteomes

Subcellular Location

Cell membrane
; Single-pass type II membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane29-52Helical

Keywords

PTM/Processing

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain79-148Peptidase M13 N-terminal
Domain149-415Peptidase M13 N-terminal
Domain525-632Peptidase M13 C-terminal
Domain701-759Peptidase M13 C-terminal

Sequence similarities

Belongs to the peptidase M13 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    867
  • Mass (Da)
    98,408
  • Last updated
    2013-05-29 v1
  • Checksum
    1E854A772E0998A7
MGKSESQMDITEMNTPKPKKKLRWSALETGLVVVVILLTIISITMIALYATYDDGVCKSSDCVKSAARIIENMDTTAEPCKDFYQYACGGWLKKNVIPETSSRYSNFDILRDELEVVLKDVLDRDNTNDILAVQKAKALYRSCINESASWTAETAIAQLNSQYGKKVLINFFVGTNDKNSTAHIIHIDQPGLGLPSRDYYECTGAYKEACSAYVSFMISVAKLILQEKHLTINESQISKEMERVMDLEVEIANATSKPEDRNNPVLLYNKMTLTELQNNFSLEINHKQFNWSEFINNIMSTVKINVENAEDVVVYAPEYLTKLKPILNKYTSRDIQNYMIWRYVMDLVNSLSRNYKDTRNAFRKALYGTTSETAVWRRCANYVNGNMENAVGRLYVEEAFSGDSKHVAAAITERIGYPDDIITDNNKLNNEYQDLNYKEDEYFENIIQSLLFSQRKRLKKLREKVDKEQWISGAAVVNAFYSATRNQIELPHVNIFTLFAVFEGKQLDFLTEVHVNDSVIKYISFFPAGILQPPFFSASQSKSLNYGGIGMVIGHEITHGFDDNGRNFNENGDLIDWWTPESAKHFKDQSQCMVYQYGNFSWDLAGGQHLSGINTLGENIADNGGVRQAYKSEIFHNVDTLCNITPHQSTPGTNGAAQTSQSYCFKFCKHRNHCISYTQFTREFLESLDSGQGGSSQKEELAYENFVKKNGKEKLLPGLDMNHKQLFFVNFAQIWCGTYRPEYAVNSIKTDTHSPGKFRPVLPKYCQGARVREGPCCRSTAKEPERVKARAAEVLPRKGPCCRSTAKEPERMKAPAAKDPEHCREKLTDYGDWISEQTGNDGGNHRAPNDYRNCDSECCGITEPKPF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KB520915
EMBL· GenBank· DDBJ
EMP37972.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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