M7CBA6 · M7CBA6_CHEMY
- ProteinNeprilysin
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids867 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- neurotensin + H2O = neurotensin(1-11) + L-isoleucyl-L-leucineThis reaction proceeds in the forward direction.
- neurotensin + H2O = neurotensin(1-10) + L-tyrosyl-L-isoleucyl-L-leucineThis reaction proceeds in the forward direction.
- substance P + H2O = substance P(1-9) + L-Leu-L-Met-NH2This reaction proceeds in the forward direction.
- substance P + H2O = substance P(1-7) + L-Phe-Gly-L-Leu-L-Met-NH2This reaction proceeds in the forward direction.
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | metal ion binding | |
Molecular Function | metalloendopeptidase activity | |
Biological Process | amyloid-beta clearance | |
Biological Process | protein processing |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameNeprilysin
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Testudinata > Testudines > Cryptodira > Durocryptodira > Americhelydia > Chelonioidea > Cheloniidae > Chelonia
Accessions
- Primary accessionM7CBA6
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type II membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 29-52 | Helical | ||||
Sequence: TGLVVVVILLTIISITMIALYATY |
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 79-148 | Peptidase M13 N-terminal | ||||
Sequence: PCKDFYQYACGGWLKKNVIPETSSRYSNFDILRDELEVVLKDVLDRDNTNDILAVQKAKALYRSCINESA | ||||||
Domain | 149-415 | Peptidase M13 N-terminal | ||||
Sequence: SWTAETAIAQLNSQYGKKVLINFFVGTNDKNSTAHIIHIDQPGLGLPSRDYYECTGAYKEACSAYVSFMISVAKLILQEKHLTINESQISKEMERVMDLEVEIANATSKPEDRNNPVLLYNKMTLTELQNNFSLEINHKQFNWSEFINNIMSTVKINVENAEDVVVYAPEYLTKLKPILNKYTSRDIQNYMIWRYVMDLVNSLSRNYKDTRNAFRKALYGTTSETAVWRRCANYVNGNMENAVGRLYVEEAFSGDSKHVAAAITERI | ||||||
Domain | 525-632 | Peptidase M13 C-terminal | ||||
Sequence: FFPAGILQPPFFSASQSKSLNYGGIGMVIGHEITHGFDDNGRNFNENGDLIDWWTPESAKHFKDQSQCMVYQYGNFSWDLAGGQHLSGINTLGENIADNGGVRQAYKS | ||||||
Domain | 701-759 | Peptidase M13 C-terminal | ||||
Sequence: LAYENFVKKNGKEKLLPGLDMNHKQLFFVNFAQIWCGTYRPEYAVNSIKTDTHSPGKFR |
Sequence similarities
Belongs to the peptidase M13 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length867
- Mass (Da)98,408
- Last updated2013-05-29 v1
- Checksum1E854A772E0998A7
Keywords
- Technical term